期刊
MOLECULES
卷 26, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/molecules26071895
关键词
Pinus koraiensis; phytoncide; anti-inflammation; gastritis; colitis
资金
- 'R&D Program for Forest Science Technology' by Korea Forest Service (Korea Forestry Promotion Institute) [FTIS2016010B10-1919-AB01]
The study confirmed the anti-inflammatory activity of two types of phytoncide extracts in animal models of gastroenteritis and colitis. Phytoncide was found to directly inhibit inflammation in digestive organs, showing potential as a functional agent in the digestive tract.
Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.
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