期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 525, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2021.111179
关键词
Leydig cells; Myoid cells; Peritubular stem cells; PDGF; Testis
资金
- National Natural Science Foundation of China [91949123, 81730042]
- Wenzhou City Science and Technology Bureau, China [ZY2019002]
This study demonstrates that peritubular stem Leydig cells are multipotent and can differentiate into Leydig cells or myoid cells depending on the inducing factors. These cells may serve as a common precursor population for maintaining the homeostasis of both Leydig and myoid cells in the adult testis.
Peritubular stem Leydig cells (SLCs) have been identified from rat testicular seminiferous tubules. However, no stem cells for peritubular myoid cells have been reported in the adult testis so far. In the present study, we tested the hypothesis that the peritubular SLCs are multipotent and able to form either Leydig or myoid cells. Using cultured tubules, we show that in the presence of PDGFAA and luteinizing hormone, SLCs became testosterone-producing Leydig cells, while in the presence of PDGFBB and TGFB, the cells formed alpha-smooth muscle actin-expressing myoid cells. This multipotency was also confirmed by culture of isolated CD90(+) SLCs. These results suggest that these stem cells outside the myoid layer are multipotent and give rise to either Leydig or myoid cells, depending on the inducing factors. These cells may serve as a common precursor population for maintaining homeostasis of both Leydig and myoid cell populations in the adult testis.
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