Article
Chemistry, Medicinal
Sang-Min Kang, Dongseob Tark, Byeong-Min Song, Gun-Hee Lee, Ju-Hee Yang, Hee-Jeong Han, Sung-Kun Yim
Summary: Crude polysaccharides extracted from seaweed and abalone viscera effectively inhibit the propagation of SARS-CoV-2 by interfering with viral entry.
Review
Biochemistry & Molecular Biology
Ademola Adetokunbo Oyagbemi, Temitayo Olabisi Ajibade, Yapo Guillaume Aboua, Idayat Titilayo Gbadamosi, Aduragbenro Deborah A. Adedapo, Abimbola Obemisola Aro, Olumuyiwa Abiola Adejumobi, Emma Thamahane-Katengua, Temidayo Olutayo Omobowale, Olufunke Olubunmi Falayi, Taiwo Olaide Oyagbemi, Blessing Seun Ogunpolu, Fasilat Oluwakemi Hassan, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Eunice Ola-Davies, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy McGaw, Prudence Ngalula Kayoka-Kabongo, Oluwafemi Omoniyi Oguntibeju, Momoh Audu Yakubu
Summary: The SARS-CoV-2 virus causing COVID-19 has led to unprecedented global health crisis and economic catastrophe. The race for vaccine development and use of available drugs against COVID-19 continues, with potential benefits from zinc supplementation being explored as a possible innovative therapeutic approach.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Nikola Gligorijevic, Mirjana Radomirovic, Olgica Nedic, Marija Stojadinovic, Urmila Khulal, Dragana Stanic-Vucinic, Tanja Cirkovic Velickovic
Summary: The global outbreak of COVID-19 caused by SARS-CoV-2 has led to numerous clinical trials investigating the potential of polyphenols in prevention and treatment, providing a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Jakob J. Malin, Isabelle Suarez, Vanessa Priesner, Gerd Fatkenheuer, Jan Rybniker
Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Review
Biology
Manuel Castillejos-Lopez, Luz Maria Torres-Espindola, Juan Carlos Huerta-Cruz, Edgar Flores-Soto, Bianca S. Romero-Martinez, Rafael Velazquez-Cruz, Anjarath Higuera-Iglesias, Angel Camarena, Ana Karen Torres-Soria, Citlaltepetl Salinas-Lara, Rosario Fernandez-Plata, Noe Alvarado-Vasquez, Hector Solis-Chagoyan, Victor Ruiz, Arnoldo Aquino-Galvez
Summary: The SARS-CoV-2 pandemic has confirmed the predictions made by virologists for decades. The challenge faced by the world is to find a treatment, and repurposing drugs is a viable and fast option. However, the mechanisms of action of some drugs are unknown even though they are approved for human use. Therefore, it is ideal, but not necessary, to understand the basic mechanisms of action in order to justify the therapeutic application of a drug to a new disease.
Review
Pharmacology & Pharmacy
Shuangshuang Yang, Shan Shen, Ning Hou
Summary: A review of studies suggests that ivermectin may be effective in treating mild to moderate COVID-19 cases. However, there is no clear evidence or guidelines recommending its use as a therapeutic agent, and caution should be exercised by physicians. Self-medication is not recommended for patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Applied
Poornima P. Vijayan, P. G. Chithra, Pinky Abraham, Jesiya Susan George, Hanna J. Maria, T. Sreedevi, Sabu Thomas
Summary: Nanotechnologists and material scientists are developing sustainable antiviral surface coatings for various substrates to combat the spread of COVID-19, utilizing nanomaterials that interact with the spike protein of SARS-CoV-2. These coatings inhibit viral entry into host cells by depleting the spike glycoprotein, offering important implications for epidemic prevention.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Microbiology
Muneerah M. Aleissa, Emily A. Silverman, Luisa M. Paredes Acosta, Cameron T. Nutt, Aaron Richterman, Francisco M. Marty
Summary: Remdesivir has been approved for treating hospitalized patients with COVID-19, showing improved survival rates and decreased viral RNA levels when used early in the course of the disease.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Christopher Hopkins, Chidinma Onweni, Victoria Zambito, DeLisa Fairweather, Kathryn McCormick, Hideki Ebihara, Thomas Caulfield, Yu Shrike Zhang, W. David Freeman
Summary: This perspective article emphasizes the importance of combination therapies in battling the severity of complications from SARS-CoV-2 infection, proposing different systems for fast and efficient combinatorial assessment of therapeutic candidates.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Miguel Angel Martinez
Summary: This article discusses whether drug repurposing is the best strategy for developing effective therapies to treat COVID-19 and other viral human infections.
DRUG DISCOVERY TODAY
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Lili Tian, Zehan Pang, Maochen Li, Fuxing Lou, Xiaoping An, Shaozhou Zhu, Lihua Song, Yigang Tong, Huahao Fan, Junfen Fan
Summary: Molnupiravir is a broad-spectrum antiviral drug with the potential to treat and prevent various coronaviruses, including SARS-CoV-2. Clinical trials have shown its beneficial effects and favorable safety profile for mild to moderate COVID-19 patients. Molnupiravir has the potential to be a therapeutic candidate against COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Gregorio Paolo Milani, Marina Macchi, Anat Guz-Mark
Summary: Vitamin C may play a role in the treatment of COVID-19 patients, but current research data on its application in prevention and treatment are limited, further investigation is needed.
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Chemistry, Medicinal
Sung-Kun Yim, Kian Kim, SangHo Chun, TaeHawn Oh, WooHuk Jung, KyooJin Jung, Chul-Ho Yun
Article
Biochemistry & Molecular Biology
Sung-Kun Yim, Inhee Kim, Boyd Warren, Jungwon Kim, Kyoojin Jung, Bosung Ku
Summary: This study found significant antiviral activity against SARS-CoV-2 pseudovirus entry for siphonaxanthin from Codium fragile, while fucoxanthin from Undaria pinnatifida sporophyll did not exhibit this effect. Predicted acute toxicities were relatively low, with indications of gastrointestinal absorption for these marine carotenoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Sang-Min Kang, Dongseob Tark, Byeong-Min Song, Gun-Hee Lee, Ju-Hee Yang, Hee-Jeong Han, Sung-Kun Yim
Summary: Crude polysaccharides extracted from seaweed and abalone viscera effectively inhibit the propagation of SARS-CoV-2 by interfering with viral entry.