Article
Biochemistry & Molecular Biology
Mathias Flensted-Jensen, Martin Gram, Flemming Dela, Jorn Wulff Helge, Steen Larsen
Summary: In this study involving 12 sedentary obese individuals at risk of developing T2D, it was found that high intensity interval training (HIT) significantly decreased ROS production, increased antioxidant protein levels, and improved mitochondrial respiratory capacity within a short period of time. These findings suggest that a relatively small amount of HIT can effectively enhance antioxidant status and lower oxidative stress in muscle cells, potentially protecting against the development of cardiovascular disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiaoguang Liu, Miaomiao Xu, Yang Yu, Yingjie Chen, Xinyu Weng, Lin Zhu
Summary: PD-1 plays an important role in cisplatin-induced skeletal muscle atrophy, with PD-1 knockout exacerbating muscle wasting and influencing inflammation and oxidative stress in muscles.
Article
Biochemistry & Molecular Biology
Yu Kitaoka
Summary: Nrf2 is believed to play a crucial role in protecting cells against oxidative stress and is also involved in energy metabolism. This review briefly discusses the role of Nrf2 in skeletal muscle metabolism from the perspective of exercise physiology.
Review
Biochemistry & Molecular Biology
Maria F. Torre, Maria Martinez-Ferran, Nestor Vallecillo, Sergio L. Jimenez, Carlos Romero-Morales, Helios Pareja-Galeano
Summary: There is insufficient evidence to confirm that antioxidant vitamins intake can minimize delayed-onset muscle soreness after eccentric exercise. Although some studies show the beneficial effects of chronic supplementation with vitamins C and E on muscle soreness, further research is needed to confirm their effectiveness in this context.
Review
Cell Biology
Hongyang Xu, Holly Van Remmen
Summary: SERCA pump plays a crucial role in maintaining cellular calcium homeostasis and its function is closely linked to muscle health and function. Pathological conditions can impair SERCA activity, leading to muscle atrophy and weakness. Therefore, targeting SERCA activity has emerged as a potential therapeutic approach for muscle pathologies.
Article
Multidisciplinary Sciences
Stefania Casagrande, Maciej Dzialo, Lisa Trost, Kasja Malkoc, Edyta Teresa Sadowska, Michaela Hau, Barbara Pierce, Scott McWilliams, Ulf Bauchinger
Summary: Understanding energy metabolism is crucial in ecological studies of free-ranging animals. This study focused on the use of red blood cells (RBCs) as a minimally invasive method to estimate metabolic rate in European starlings. The findings showed that RBC metabolism was a better predictor of whole-organism energy metabolism than other tissues, with the pectoral muscle contributing the most to the overall metabolic rate.
Article
Medicine, Research & Experimental
Susrutha Puthanmadhom Narayanan, Daniel O'Brien, Mayank Sharma, Karl Miller, Peter Adams, Joao F. Passos, Alfonso Eirin, Tamas Ordog, Adil E. Bharucha
Summary: In diabetic gastroenteropathy, levels of mitochondrial DNA- and nuclear DNA-encoded mitochondrial genes are reduced and increased, associated with reduced mitochondrial density, neuropathy, and delayed gastric emptying, and correlated with cognate miRNAs.
Article
Agriculture, Dairy & Animal Science
Jinzhong Jing, Ying He, Yan Liu, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Lianqiang Che, Bo Kang, Hua Zhao
Summary: The vulnerability of pig skeletal muscle to oxidative damage and subsequent growth retardation has been studied. Selenoproteins, regulated by dietary selenium levels, play a significant role in protecting skeletal muscle from oxidative stress and promoting growth.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bruno Luiz da Silva Pieri, Matheus Scarpatto Rodrigues, Hemelin Resende Farias, Gustavo de Bem Silveira, Victoria de Souza Gomes da Cunha Ribeiro, Paulo Cesar Lock Silveira, Claudio Teodoro De Souza
Summary: Insulin resistance is the link between obesity and type 2 diabetes mellitus, and oxidative stress may play a role in this process. This study found that NAC supplementation improved insulin resistance and blood glucose levels by reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luisa Gorza, Elena Germinario, Maurizio Vitadello, Irene Guerra, Federica De Majo, Francesca Gasparella, Paolo Caliceti, Libero Vitiello, Daniela Danieli-Betto
Summary: Curcumin administration has beneficial effects on dystrophic muscle by improving myofiber maturation, increasing muscle fiber types, enhancing muscle strength, reducing oxidative damage, and regulating nNOS activity.
Article
Biology
Hiroaki Eshima, Justin L. Shahtout, Piyarat Siripoksup, MacKenzie J. Pearson, Ziad S. Mahmassani, Patrick J. Ferrara, Alexis W. Lyons, John Alan Maschek, Alek D. Peterlin, Anthony R. P. Verkerke, Jordan M. Johnson, Anahy Salcedo, Jonathan J. Petrocelli, Edwin R. Miranda, Ethan J. Anderson, Sihem Boudina, Qitao Ran, James E. Cox, Micah J. Drummond, Katsuhiko Funai
Summary: ROS accumulation is a key characteristic of skeletal muscle atrophy. The role of ROS in the loss of muscle mass and strength is not clear. This study reveals that LOOH, a type of ROS, promotes muscle atrophy in a lysosomal-dependent manner. Inhibition of LOOH prevents muscle atrophy and weakness in both young and old mice, suggesting that LOOH-derived carbonyl stress mediates age- and disuse-induced muscle dysfunction.
Article
Engineering, Environmental
Wang Shengchen, Liu Jing, Yao Yujie, Wang Yue, Xu Shiwen
Summary: The environmental problem of Microplastics pollution has caused a significant threat to human and animal health globally. The exposure to different sizes of polystyrene microplastics affects the growth and repair of skeletal muscles in mice, with delayed regeneration and negative correlation with particle size. Mechanistic research revealed that ROS overproduction caused by microplastics disturbed muscle regeneration and directed the fate of satellite cells.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mami Yamada, Eiji Warabi, Hisashi Oishi, Vitor A. Lira, Mitsuharu Okutsu
Summary: Oxidative stress is important in skeletal muscle atrophy during cancer cachexia, with glycolytic muscles being more affected. The protein p62 plays a role in activating Nrf2 and increasing expression of antioxidant proteins in skeletal muscles, potentially protecting against muscle wasting. These findings suggest that p62 could be a therapeutic target for treating cancer cachexia.
Article
Biochemistry & Molecular Biology
Mami Yamada, Eiji Warabi, Hisashi Oishi, Vitor A. Lira, Mitsuharu Okutsu
Summary: Oxidative stress plays a crucial role in skeletal muscle atrophy during cancer cachexia, with more glycolytic muscles being more affected. Here, the researchers showed that p62, when phosphorylated, competitively binds to Keap1 and activates Nrf2, leading to the transcription of antioxidant genes in skeletal muscle. The overexpression of p62 in glycolytic muscles increased the expression of antioxidant proteins and mitigated muscle wasting in a mouse model of cancer cachexia.
Article
Biochemistry & Molecular Biology
Aeyung Kim, Sang-Min Park, No Soo Kim, Haeseung Lee
Summary: Ginsenoside Rc (gRc) effectively reduces oxidative stress-induced damage to muscle cells, promotes mitochondrial function and ATP production, and slows down muscle degradation and loss. gRc also regulates genes related to mitochondrial mass and biogenesis, while suppressing genes associated with muscle degradation. These findings suggest that gRc has potential as a promising treatment for muscle loss and weakness.
Article
Medicine, Research & Experimental
Syeda Kiran Shahzadi, Hezlin Marzook, Rizwan Qaisar, Firdos Ahmad
Summary: NRK-2 plays a protective role in pressure overload-induced cardiac remodeling, and its genetic ablation may lead to cardiomyopathy, fibrosis, and cardiac dysfunction. NRK-2 exerts its protective effects by inhibiting JNK activation and mitochondrial depolarization.
Article
Cardiac & Cardiovascular Systems
Asima Karim, Tahir Muhammad, Islam Shah, Javaidullah Khan, Rizwan Qaisar
Summary: This study found that plasma haptoglobin levels were negatively associated with muscle health and physical capacity in CHF patients. Patients with the Hp2-2 phenotype also showed higher expressions of inflammation and oxidative stress markers, as well as lower scores on quality of life parameters.
HEART LUNG AND CIRCULATION
(2022)
Article
Cell Biology
Rizwan Qaisar, Shahjahan Ustrana, Tahir Muhammad, Islam Shah
Summary: Research suggests that in patients with chronic obstructive pulmonary disease (COPD), the disruption of sarcoplasmic reticulum (SR) protein homeostasis (SR stress) and myonuclear disorganization are associated with sarcopenia. Additionally, COPD patients show upregulation of SR stress markers, disruption of myonuclear organization, and elevated levels of oxidative stress, all contributing to muscle weakness in advanced COPD.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Cell Biology
Ayesha M. Yusuf, Rizwan Qaisar, Abaher O. Al-Tamimi, Manju Nidagodu Jayakumar, James R. Woodgett, Walter J. Koch, Firdos Ahmad
Summary: The loss of cardiomyocyte-GSK-3 beta promotes cardiomyocyte and resident CPC proliferation post-myocardial infarction, potentially regulated by dysregulated growth factors post-MI. Inhibiting cardiomyocyte-GSK-3 beta could be a helpful strategy for in situ cardiac regeneration post-ischemic injury.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Asima Karim, M. Shahid Iqbal, Tahir Muhammad, Rizwan Qaisar
Summary: A biomarker to accurately predict muscle loss in Parkinson's disease (PD) patients has not yet been found. In this study, we evaluated the biomarkers of neuromuscular junction stability and found that levels of CAF22 were elevated while levels of BDNF and GDNF were reduced in PD patients. These biomarkers showed significant associations with muscle loss indicators. Combining these biomarkers into a cumulative risk score enhanced the diagnostic accuracy of muscle loss.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Asima Karim, Tahir Muhammad, M. Shahid Iqbal, Rizwan Qaisar
Summary: This study found that COVID-19 infection can lead to muscle decline, which persists for at least six months after infection. Plasma CAF22 may be useful in detecting muscle and functional decline in these patients. Timely evaluation and intervention of sarcopenia may be critical in COVID-19 treatment.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Engineering, Aerospace
Anu V. Ranade, Amir Ali Khan, Muhammad Tehsil Gul, Josemin Jose, Gopika Ramachandran, Rizwan Qaisar, Asima Karim, Firdos Ahmad, Wael M. Abdel-Rahman
Summary: This study investigates the role of elevated endoplasmic reticulum (ER) stress in testicular atrophy during simulated microgravity conditions. The results demonstrate that 4PBA, an ER stress inhibitor, can prevent testicular atrophy and partially restore testicular microarchitecture.
Article
Neurosciences
Rizwan Qaisar, Asima Karim, M. Shahid Iqbal, Shaea A. Alkahtani, Firdos Ahmad, Hossam Kamli
Summary: ACE inhibitors are beneficial for hypertensive Alzheimer's disease (AD) patients, as they can preserve neuromuscular junction (NMJ) function, improve muscle strength and physical capacity. ACE inhibitors show superior effects compared to other antihypertensive medications on muscle strength, physical capacity, and prevention of NMJ degradation. These changes are associated with reduced oxidative stress.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Multidisciplinary Sciences
Amna Khalid, Rizwan Qaisar, M. Azhar Hussain, Asima Karim
Summary: This study found that girls living at higher latitudes have a delayed age at menarche. Higher latitude is associated with lower levels of circulating follicle stimulating hormone (FSH) and physical growth parameters such as body mass index (BMI), waist-hip ratio, and waist-height ratio. On the other hand, lower socio-economic status (SES) is associated with lower growth hormone (GH) levels and lower BMI.
Review
Endocrinology & Metabolism
Akash Mitra, Rizwan Qaisar, Bipasha Bose, P. Sudheer Shenoy
Summary: Skeletal muscle is an important component of the musculo-skeletal system, contributing to stability and mobility. However, improper functioning of skeletal muscles can lead to diseases such as sarcopenia, muscular dystrophies, and cachexia. On the other hand, skeletal muscles have the ability to undergo hypertrophy and enhanced functioning through exercise. This review focuses on the role and regulation of myostatin in muscle regeneration and molecular functions.
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, Research & Experimental
Rizwan Qaisar, Hossam Kamli, Asima Karim, Tahir Muhammad, Firdos Ahmad, Ahmad Shaikh
Summary: This study found that treatment with angiotensin receptor blockers (ARBs) can protect muscle health and functional capacity in hypertensive patients with chronic obstructive pulmonary disease (COPD). ARBs treatment improved grip strength, gait speed, and reduced levels of plasma C-terminal agrin fragment-22 (CAF22), a marker of neuromuscular junction degradation. ARBs also prevented the decline in SPPB components, including balance, gait speed, and the ability to rise from a chair.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Rizwan Qaisar
Summary: The integrity and preservation of the neuromuscular junction (NMJ) is crucial for maintaining a healthy skeletal muscle. Defects in the three cellular components of NMJ negatively impact skeletal muscle mass and strength. NMJ repair could be a potential therapy for muscle disorders.
Article
Health Care Sciences & Services
Rizwan Qaisar, M. Shahid Iqbal, Asima Karim, Tahir Muhammad, Firdos Ahmad
Summary: The SarQoL questionnaire is a reliable tool for evaluating the quality of life in sarcopenic patients. Increased intestinal permeability is associated with lower scores in SarQoL domains for sarcopenic patients.
QUALITY OF LIFE RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Rizwan Qaisar, Asima Karim, Tahir Muhammad, Shaea A. Alkahtani, Hossam Kamli, Firdos Ahmad
Summary: This study investigated the effects and mechanisms of statin medications on muscle strength and physical capacity in patients with chronic obstructive pulmonary disease (COPD). The results showed that statins can exacerbate muscle decline but do not contribute to physical compromise in COPD patients.
RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rizwan Qaisar, Asima Karim, M. Shahid Iqbal, Firdos Ahmad, Ahmad Shaikh, Hossam Kamli, Nizar A. Khamjan
Summary: This study investigated the association of elevated intestinal permeability with postural dysfunction in patients with Alzheimer's disease (AD). The results showed that elevated intestinal permeability is associated with postural dysfunction in AD patients and that plasma zonulin measurement can be used to diagnose postural dysfunction. This finding is important for non-ambulant and/or comatose AD patients and highlights the therapeutic potential of repairing the intestinal leak to improve postural control and reduce the risk of falls in AD patients.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.