Tip60 activates Hoxa9 and Meis1 expression through acetylation of H2A.Z, promoting MLL-AF10 and MLL-ENL acute myeloid leukemia

Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance

(2020) Akihiko Numata et al.   BLOOD

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

(2018) Benedetto Daniele Giaimo et al.   NUCLEIC ACIDS RESEARCH

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

(2016) Ngai Cheung et al.   CANCER CELL

EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation

(2016) Suman K. Pradhan et al.   MOLECULAR CELL

Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

(2016) Xiaoping Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

(2016) Chrysa M Latrick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

(2016) Xiaoping Liang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular basis and specificity of H2A.Z–H2B recognition and deposition by the histone chaperone YL1

(2016) Chrysa M Latrick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes

(2016) Maria-Paz Garcia-Cuellar et al.   Cell Reports

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

(2015) Chun-Wei Chen et al.   EXPERIMENTAL HEMATOLOGY

The DREAM complex promotes gene body H2A.Z for target repression

(2015) Isabel Latorre et al.   GENES & DEVELOPMENT

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

(2015) Philipp Rathert et al.   NATURE

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

(2015) Junwei Shi et al.   NATURE BIOTECHNOLOGY

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation

(2015) Yuefeng Sun et al.   Scientific Reports

AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes

(2014) Aniruddha J. Deshpande et al.   CANCER CELL

Nucleosomes Are Context-Specific, H2A.Z-Modulated Barriers to RNA Polymerase

(2014) Christopher M. Weber et al.   MOLECULAR CELL

ANP32E is a histone chaperone that removes H2A.Z from chromatin

(2014) Arnaud Obri et al.   NATURE

Genome-Wide Analysis of the Chromatin Composition of Histone H2A and H3 Variants in Mouse Embryonic Stem Cells

(2014) Masashi Yukawa et al.   PLoS One

Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression

(2014) Thomas Kusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design and validation of a Tip60 histone acetyltransferase inhibitor

(2014) Chunxia Gao et al.   Scientific Reports

Dynamic Interactions between TIP60 and p300 Regulate FOXP3 Function through a Structural Switch Defined by a Single Lysine on TIP60

(2014) Yan Xiao et al.   Cell Reports

Post-translational modifications of the histone variant h2az

(2013) Ana Sevilla et al.   Stem Cell Research

MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells

(2013) Emanuel Maethner et al.   Cell Reports

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

(2012) William J. Harris et al.   CANCER CELL

H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-Renewal and Differentiation

(2012) Gangqing Hu et al.   Cell Stem Cell

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization

(2012) Clemens Bönisch et al.   NUCLEIC ACIDS RESEARCH

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

(2012) Kelly Coffey et al.   PLoS One

H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions

(2012) Manching Ku et al.   GENOME BIOLOGY

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

(2011) Q.-f. Wang et al.   BLOOD

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis

(2011) Jiaying Tan et al.   CANCER CELL

Tip60: Connecting chromatin to DNA damage signaling

(2011) Yingli Sun et al.   CELL CYCLE

Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer

(2011) F. Valdes-Mora et al.   GENOME RESEARCH

Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation

(2011) Kwang Won Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

Individual Lysine Acetylations on the N Terminus ofSaccharomyces cerevisiaeH2A.Z Are Highly but Not Differentially Regulated

(2010) Monika Mehta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone variants — ancient wrap artists of the epigenome

(2010) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

(2008) Menno P. Creyghton et al.   CELL

An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity

(2008) Thomas G. Fazzio et al.   CELL