Article
Biochemistry & Molecular Biology
Nosra Methneni, Khawla Ezdini, Nouha Ben Abdeljelil, Joris Van Loco, Kathy Van den Houwe, Riheb Jabeur, Ons Fekih Sallem, Ahlem Jaziri, Mercedes Fernandez-Serrano, Nezar H. Khdary, Hedi Ben Mansour
Summary: The study evaluated the toxicity of textile dyeing effluent (TDE) on male mice, finding high levels of chromium, arsenic, and strontium in the TDE. Exposure to TDE led to oxidative stress and histological damage in liver and kidney tissues, suggesting high toxicity. Metals and textile dyes in the TDE may be responsible for the observed toxicological effects, with potential health risks for wildlife and humans near Monastir city.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Arzu Ulvi, Senar Aydin, Mehmet Emin Aydin
Summary: This study examined the concentrations and distribution of pharmaceuticals in the influent and effluent of a municipal wastewater treatment plant and hospital effluents. It found that beta-blockers and psychiatric drugs were detected in high concentrations in the wastewater samples, with hospitals contributing 2-4% of total pharmaceuticals in the plant. The removal of pharmaceuticals in the treatment plant ranged from 23% to 54%.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vaskuri G. S. Sainaga Jyothi, Harithasree Veerabomma, Kamatham Pushpa Tryphena, Dharmendra Kumar Khatri, Shashi Bala Singh, Jitender Madan
Summary: The dermal LD50 of meloxicam emulgel was found to be > 2000 mg/kg in Wistar rats, and no significant adverse effects were noticed in subacute toxicity studies. Therefore, topical administration of meloxicam emulgel may be considered safe.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Environmental Sciences
Sara Peixoto, Barbara Santos, Graca Lopes, Patricia Dias-Pereira, Isabel Lopes
Summary: Acid mine drainage (AMD) is highly toxic to aquatic stages of amphibians, particularly to embryos of the green frog. High concentrations of AMD increased mortality and malformation rates, and reduced body length and growth rate in both embryos and tadpoles. Histological observations revealed abnormalities in various tissues of AMD-exposed tadpoles. Therefore, implementing efficient remediation methodologies for AMD is crucial.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ahmed Massoud, Moustafa SaadAllah, Naief A. Dahran, Nasr Elsayed Nasr, Ismael El-Fkharany, Mohamed S. Ahmed, Khalaf F. Alsharif, Ehab Kotb Elmahallawy, Aly Derbalah
Summary: The toxicity of organophosphorus insecticides, such as malathion, is a major global health concern. This study investigated the effects of prolonged exposure to low doses of malathion on enzyme activity and histopathology in animal models. The results showed significant changes in enzyme activity and various organ pathologies in rats treated with malathion for an extended period.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Hany M. R. Abdel-Latif, Mahmoud A. O. Dawood, Samy F. Mahmoud, Mustafa Shukry, Ahmed E. Noreldin, Hanan A. Ghetas, Mohamed A. Khallaf
Summary: Copper oxide nanoparticles (CuONPs) are increasingly being manufactured for varied purposes, but their release into aquatic ecosystems is causing toxicological effects on exposed aquatic organisms. This study investigated the effects of CuONPs on Nile tilapia at sub-lethal levels, revealing significant changes in biochemical indices, histopathological alterations, and transcriptomic responses. The study provides valuable insights into the mechanisms of CuONPs toxicity in Nile tilapia at multiple levels.
Article
Environmental Sciences
Emma B. Meade, Luke R. Iwanowicz, Nicklaus Neureuther, Gregory H. LeFevre, Dana W. Kolpin, Hui Zhi, Shannon M. Meppelink, Rachael F. Lane, Angela Schmoldt, Aurash Mohaimani, Olaf Mueller, Rebecca D. Klaper
Summary: This study investigates the biological impacts and biomarkers of wastewater treatment plant (WWTP) effluent exposure on zebrafish embryos through transcriptomics analysis. The results reveal that WWTP effluent not only affects traditional markers of endocrine disruption but also impacts a wide range of biological functions and pathways, including cardiac, neurological, visual, metabolic, and signaling pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Priyanka Mathur, Kusum Rani, Pradeep Bhatnagar, Swaran Jeet Singh Flora
Summary: Hospital effluents contain harmful substances such as drugs, radioactive elements, and pathogens. If effluents from treatment plants mix with potable water, it can have detrimental/toxic effects. This study investigated the toxic effects of hospital effluent on mice's reproductive characteristics when orally administered daily for 60 days. The study found that the treated hospital effluent still contains toxicants that can lead to abnormalities in sperm morphology, such as absent heads, bent necks, and coiled tails.
Article
Environmental Sciences
Siti Norliyana Zubaidi, Wasim S. M. Qadi, Syahida Maarof, Norazlan Mohmad Misnan, Halimatul Saadiah Mohammad Noor, Hamizah Shahirah Hamezah, Syarul Nataqain Baharum, Nurwahyuna Rosli, Faidruz Azura Jam, Ebtesam Al-Olayan, Chuanyi Wang, Khaoula Hellal, Nawal Buzgaia, Ahmed Mediani
Summary: This study used advanced proton nuclear magnetic resonance (H-1 NMR) techniques to evaluate the acute oral toxicity of A. muricata leaf ethanol extract in Sprague Dawley rats. The results showed no significant toxicity at a dose of 2000 mg/kg. The findings suggest that A. muricata leaf ethanol extract can be safely consumed with an LD50 greater than 2000 mg/kg.
Article
Environmental Sciences
Xiangsheng Hong, Le Zhang, Jinmiao Zha
Summary: This study evaluated the toxicity and environmental risks of vortioxetine in non-target organisms using zebrafish as an experimental model. The results showed that vortioxetine had significant adverse effects on survival, development, behavior, and organ health of zebrafish. Furthermore, even at concentrations slightly lower than therapeutic levels, vortioxetine induced anxiolytic-like behavior in zebrafish.
ENVIRONMENTAL POLLUTION
(2022)
Article
Chemistry, Analytical
Peter G. Schumann, Emma B. Meade, Hui Zhi, Gregory H. LeFevre, Dana W. Kolpin, Shannon M. Meppelink, Luke R. Iwanowicz, Rachael F. Lane, Angela Schmoldt, Olaf Mueller, Rebecca D. Klaper
Summary: This study investigated the neurological impacts of treated wastewater effluent on fathead minnows in a stream located upstream and downstream of a WWTP effluent outfall. It found sex-dependent effects on neuronal gene expression and identified potential gene biomarkers for monitoring complex contaminant mixtures. The study also questioned the use of single-compound exposures for accurately characterizing environmental risks.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2022)
Article
Environmental Sciences
Maroua Jenzri, Chayma Gharred, Zied Bouraoui, Hamadi Guerbej, Jamel Jebali, Tahar Gharred
Summary: This study investigated the toxicity of bisphenol A (BPA) and bisphenol S (BPS) on sea cucumbers. The results showed that exposure to BPA and BPS caused oxidative stress, neurotoxicity, and histopathological lesions in the respiratory tree of the sea cucumbers. BPA had greater effects on oxidative stress and neurotoxicity compared to BPS.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Pei-Pei Sun, Ching-Shu Lai, Chung-Jung Hung, Periyathambi Dhaiveegan, Mei-Ling Tsai, Chun-Lun Chiu, Jim-Min Fang
Summary: The 90-day subchronic oral consumption of AuNPs did not show significant toxicity in mice, except for minor infiltration in the kidneys of male mice treated with a high dose and reduced A/G ratio and elevated platelet indices in female mice.
Article
Biochemistry & Molecular Biology
Murtaza H. Syed, Syeda A. Rubab, Syed R. Abbas, Syed Qutaba, Mior A. K. Mohd Zahari, Norhayati Abdullah
Summary: Cadmium (Cd), a heavy metal, accumulates in the liver and forms a complex with metallothionein protein, ultimately affecting vital organs. This study examines the effect of different concentrations of cadmium acetate (CA) doses in drinking water for different exposure times in murine models. Histopathological and biochemical examinations were conducted, revealing extensive degenerative effects and higher cadmium levels in serum, kidney, and liver tissues. The study concludes that even low doses of CA exposure are hazardous to murine models with damaging effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Bondi Gevao, Saif Uddin, Divya Krishnan, Smitha Rajagopalan, Nazima Habibi
Summary: This study investigated the concentrations of antibiotics in wastewater from two treatment plants in Kuwait, with higher influent concentrations observed, showing seasonal variations with the highest levels during winter-summer transitions. The research provides the first reported data on antibiotic concentrations in wastewater in Kuwait, laying the groundwork for further evaluation of environmental impact.