Article
Geriatrics & Gerontology
Hyunsuk Kim, Mun Jung Ko, Chi-Yeon Lim, Eunjin Bae, Young Youl Hyun, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O. Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong
Summary: This study found that high physical activity is an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Graciela Muniz-Terrera, Thomas M. Gill
Summary: This study reveals that there is a terminal decline in physical function among older adults, which is comparable to the established terminal decline phenomenon in cognition and may be associated with impending death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Yuanyuan Wang, Alice Owen, Angus Franks, Ilana Ackerman, Sharyn M. Fitzgerald, Susan Liew, Robyn L. Woods, Anita E. Wluka, John J. McNeil, Flavia M. Cicuttini
Summary: Hip replacement surgery can significantly improve physical function in older adults, and the degree of preoperative physical impairment is an important indicator for predicting surgical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Yuanyuan Wang, Alice Owen, Angus Franks, Ilana Ackerman, Sharyn M. Fitzgerald, Susan Liew, Robyn L. Woods, Anita E. Wluka, John J. McNeil, Flavia M. Cicuttini
Summary: This study aimed to examine the effect of knee replacement on functional outcomes in older adults and identify the factors associated with functional improvement. The results showed that knee replacement led to improvement in physical function, but the postoperative functional status remained lower than age-matched controls. The degree of preoperative physical function impairment was a strong predictor of functional improvement.
Article
Geriatrics & Gerontology
Ulrike Dapp, Dominic Vinyard, Stefan Golgert, Sebastian Krumpoch, Ellen Freiberger
Summary: This study used a new method to evaluate gait characteristics of older adults and stratified gait parameters based on functional ability. The results showed that functional level stratification revealed a wide range of functional decline for all gait parameters, and had greater differentiation than age stratification.
Article
Neurosciences
Emence Cavailles, Kristine Yaffe, Terri Blackwell, Daniel Buysse, Katie Stone, Yue Leng
Summary: Specific sleep characteristics are associated with cognitive decline, while multidimensional sleep health measurement is associated with greater cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, General & Internal
Pablo Martinez-Amezcua, Danielle Powell, Pei-Lun Kuo, Nicholas S. Reed, Kevin J. Sullivan, Priya Palta, Moyses Szklo, Richey Sharrett, Jennifer A. Schrack, Frank R. Lin, Jennifer A. Deal
Summary: Hearing impairment was found to be associated with poorer physical function, reduced walking endurance, and faster decline in physical function among nearly 3000 participants in a cohort study. The results suggest that managing hearing impairment may delay decline in physical function, which warrants further investigation.
Article
Critical Care Medicine
Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert
Summary: Arousal during sleep triggers ventricular repolarization lability, which may increase the risk of long-term cardiovascular mortality. The QT variability index during arousal is independently associated with all-cause and cardiovascular mortality, indicating maladaptation of ventricular repolarization to the arousal stimulus. Further study is needed to determine if arousal suppression can reduce ventricular repolarization lability and subsequent mortality, and if arousal-related QT variability index can be used for more accurate risk stratification.
Article
Geriatrics & Gerontology
Scott R. Bauer, Peggy M. Cawthon, Kristine E. Ensrud, Anne M. Suskind, John C. Newman, Howard A. Fink, Kaiwei Lu, Rebecca Scherzer, Andrew R. Hoffman, Kenneth Covinsky, Lynn M. Marshall
Summary: The severity of LUTS is associated with incident mobility and ADL limitations among older men, but not with cognition-dependent task limitations. Increased clinical attention to the risk of functional limitations among older men with LUTS is likely warranted.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Megan M. Marron, Eric S. Orwoll, Peggy M. Cawthon, Nancy E. Lane, Anne B. Newman, Jane A. Cauley
Summary: In this study, the researchers found that certain metabolites associated with polyunsaturated fatty acids are correlated with muscle mass, gait speed, and other physical performance measures in older men. These findings suggest that these specific oxylipins may have anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Paul J. Laurienti, Michael E. Miller, Robert G. Lyday, Madeline C. Boyd, Alexis D. Tanase, Jonathan H. Burdette, Christina E. Hugenschmidt, W. Jack Rejeski, Sean L. Simpson, Laura D. Baker, Chal E. Tomlinson, Stephen B. Kritchevsky
Summary: Deficits in physical function that occur with aging contribute to declines in quality of life and increased mortality. There has been a growing interest in examining associations between physical function and neurobiology. The current study examined baseline functional brain networks in 192 individuals from the Brain Networks and mobility (B-NET) study and found physical function and BMI to be associated with sensorimotor and dorsal attention network connectivity. Future work is needed to understand the causal direction of these relationships.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Xiaoguang Zhao, Huiming Huang, Chenya Du
Summary: This study examines the association between physical fitness and cognitive function in community-dwelling older adults. The findings suggest that grip strength and the 6-minute walk are closely related to cognitive function. It is important to focus on improving physical fitness to prevent or improve cognitive dysfunction in older persons.
Article
Geriatrics & Gerontology
Keigo Imamura, Naoto Kamide, Masataka Ando, Haruhiko Sato, Miki Sakamoto, Yoshitaka Shiba
Summary: This study aimed to investigate the relationship between social isolation and future decline in physical function in older adults. The results showed that social isolation was an independent risk factor for future decline in the Timed Up and Go (TUG) test, but not for other physical functions. These findings suggest that assessing social isolation may be necessary to evaluate the risk of physical performance decline.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Sport Sciences
Jason J. Wilson, Ilona McMullan, Nicole E. Blackburn, Mathias Skjodt, Paolo Caserotti, Maria Gine-Garriga, Ana Farche, Jochen Klenk, Dhayana Dallmeier, Manuela Deidda, Marta Roque i Figuls, Mark A. Tully
Summary: The study found that older adults who spent less time in prolonged sedentary bouts were associated with better physical function, while those who had fewer prolonged sedentary bouts were associated with shorter chair stand time and longer unipedal stance time. Mixed associations were found between 10- to 29-minute sedentary bouts and physical function in older adults.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Multidisciplinary Sciences
Crystal M. Glover, Ana W. Capuano, Robert S. Wilson, David A. Bennett, Lisa L. Barnes
Summary: This study identified correlates of perceived stress among older African Americans at environmental, sociocultural, behavioral, and biological levels. Protective factors such as larger life space, social network size, purpose in life, and higher global cognition were associated with lower levels of perceived stress. Future research is needed to explore how changes in these correlates may impact perceived stress in this population.
Article
Health Care Sciences & Services
Lisa Van Wilder, Brecht Devleesschauwer, Els Clays, Stefanie De Buyser, Johan Van der Heyden, Rana Charafeddine, Pauline Boeckxstaens, Dirk De Bacquer, Sophie Vandepitte, Delphine De Smedt
Summary: Chronic diseases and multimorbidity significantly reduce health-related quality of life, with different disease combinations showing either synergistic or antagonistic effects on HRQoL. The most impactful disease pair interactions were found in back pain, respiratory diseases, and joint disorders.
QUALITY OF LIFE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Thiberiu Banica, Sara Vandewalle, Hans-Georg Zmierczak, Stefan Goemaere, Stefanie De Buyser, Tom Fiers, Jean-Marc Kaufman, Jean De Schepper, Bruno Lapauw
Summary: This study investigates the changes in bone turnover markers, Wnt-signalling markers, insulin-like growth factor-1 (IGF-1) and sex steroid levels in peri-pubertal boys and how they reflect skeletal development. The study found that sex steroids, IGF-1, and bone metabolism markers are related to skeletal development in peri-pubertal boys, but the relationship is nonlinear and dependent on the maturation stage and skeletal site.
Review
Endocrinology & Metabolism
Jens Bollerslev, Lars Rejnmark, Alexandra Zahn, Ansgar Heck, N. M. Appelman-Dijkstra, Luis Cardoso, Fadil M. Hannan, Filomena Cetani, Tanja Sikjaer, Anna Maria Formenti, Sigridur Bjornsdottir, Camilla Schalin-Jantti, Zhanna Belaya, Fraser Wilson Gibb, Bruno Lapauw, Karin Amrein, Corinna Wicke, Corinna Grasemann, Michael Krebs, Eeva M. Ryhanen, Ozer Makay, Salvatore Minisola, Sebastien Gaujoux, Jean-Philippe Bertocchio, Zaki K. Hassan-Smith, Agnes Linglart, Elizabeth M. Winter, Martina Kollmann, Hans-Georg Zmierczak, Elena Tsourdi, Stefan Pilz, Heide Siggelkow, Neil J. Gittoes, Claudio Marcocci, Peter Kamenicky
Summary: This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), and parathyroid disorders in relation to pregnancy and lactation. The statement discusses areas of uncertainty and the need for further clarifications in the diagnosis and management of PHPT and HypoPT, as well as proposes interdisciplinary approaches to the treatment of parathyroid disorders in pregnant and lactating women and their newborn children.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biology
Hazal Kutlucan, Recep Onur Karabacak, Stefanie De Buyser, Ahmet Erdem, Nuray Bozkurt, Erhan Demirdag, Dirk Wildemeersch
Summary: The study aimed to assess the impact of a novel fixation method using a frameless copper-releasing intrauterine device on reducing device displacement and expulsion during and after uterine involution. The dual-anchoring technique was found to effectively reduce the risk of device displacement and expulsion, ensuring proper retention of the device.
Article
Nutrition & Dietetics
Sophie Marchand, Bruno Lapauw, Kristof Eeckloo, Mieke Deschepper
Summary: This study investigated the issue of malnutrition in a Belgian tertiary care hospital and found that it has a negative impact on patient outcomes. Furthermore, optimizing the process of malnutrition screening, diagnosing, registration, and coding can increase hospital reimbursement.
CLINICAL NUTRITION ESPEN
(2022)
Article
Veterinary Sciences
Gaelle Schils, Ellen De Paepe, Bruno Lapauw, Ellen Vanden Broecke, Laurens Van Mulders, Lynn Vanhaecke, Aurelie Lyssens, Lisa Stammeleer, Sylvie Daminet
Summary: This study evaluated the presence of traces of thiamazole in the urine of owners of hyperthyroid cats treated with antithyroid drugs. The results showed no thiamazole was detected in the urine of owners of hyperthyroid cats.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Nutrition & Dietetics
Mieke Steenbeke, Ignace De Decker, Sophie Marchand, Griet Glorieux, Wim Van Biesen, Bruno Lapauw, Joris R. Delanghe, Marijn M. Speeckaert
Summary: The study found that a diet restricted in AGE consumption for two months did not affect AGE content in the body or sRAGE concentration in the blood. The impact of blood glucose levels appears to be more significant than the consumption of dAGEs.
Article
Endocrinology & Metabolism
Maria-Cristina Burlacu, Roberto Attanasio, Laszlo Hegedus, Endre Nagy, Enrico Papini, Petros Perros, Kiswendsida Sawadogo, Marie Bex, Bernard Corvilain, Chantal Daumerie, Brigitte Decallonne, Damien Gruson, Bruno Lapauw, Rodrigo Moreno Reyes, Patrick Petrossians, Kris Poppe, Annick Van den Bruel, David Unuane
Summary: In clinical practice in Belgium, LT4 tablets are the preferred treatment for hypothyroidism. A minority of doctors would try combined LT4 + LT3 treatment in symptomatic but biochemically euthyroid patients. The use of thyroid hormones in infertile women with thyroid autoimmunity and patients with non-toxic goiter is also common in other European countries, despite the lack of evidence supporting this practice.
Article
Cardiac & Cardiovascular Systems
Simon Helleputte, Luc Van Bortel, Francis Verbeke, Jos Op 't Roodt, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: This study evaluated arterial stiffness in patients with type 1 diabetes (T1D) and without known cardiovascular disease (CVD), and compared it to other cardiovascular risk evaluation tools used in T1D. The findings showed a substantial proportion of T1D patients without CVD displayed premature arterial stiffening, and arterial stiffness was strongly associated with the risk of future cardiovascular events as well as other cardiovascular factors. However, there were heterogeneity in cardiovascular risk and differences in risk categorization between different evaluation tools. Further research is needed to refine cardiovascular risk classification and determine the clinical usefulness of assessing arterial stiffness in T1D.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tobias Puengel, Sander Lefere, Jana Hundertmark, Marlene Kohlhepp, Christian Penners, Frederique Van de Velde, Bruno Lapauw, Anne Hoorens, Lindsey Devisscher, Anja Geerts, Stephanie Boehm, Qihong Zhao, John Krupinski, Edgar D. Charles, Bradley Zinker, Frank Tacke
Summary: This study compared the effects of single drug and combination treatment as therapeutic strategies against non-alcoholic steatohepatitis (NASH). The results showed that CCR2/5 inhibition and FGF21 agonism both had favorable effects on improving NASH and fibrosis. Combination treatment amplified the beneficial effects and provided better outcomes in both short-term and long-term applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Michael R. Laurent, Stefan Goemaere, Charlotte Verroken, Pierre Bergmann, Jean-Jacques Body, Olivier Bruyere, Etienne Cavalier, Serge Rozenberg, Bruno Lapauw, Evelien Gielen
Summary: Glucocorticoid-induced osteoporosis (GIOP) is a common secondary cause of osteoporosis in adults. The Belgian Bone Club has updated its recommendations for the prevention and treatment of GIOP, emphasizing non-pharmacological measures and sufficient calcium intake. Fracture risk assessment and the use of effective drugs are recommended during treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Correction
Pediatrics
Isabelle Dehaene, Tessa Van Steenstraeten, Kris De Coen, Stefanie De Buyser, Johan Decruyenaere, Koenraad Smets, Kristien Roelens
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Dehaene Isabelle, Van Steenstraeten Tessa, De Coen Kris, De Buyser Stefanie, Decruyenaere Johan, Smets Koenraad, Roelens Kristien
Summary: This study aims to compare neonatal magnesemia in the first 15 days of neonatal life between three groups and explore its associations with child outcomes. The results show that neonatal magnesemia is significantly higher in the preeclampsia group compared to the control and neuroprotection groups. The study found mean differences in neonatal magnesemia between children not exposed to MgSO4 antenatally, children exposed for fetal neuroprotection, and children exposed for maternal eclampsia prevention.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Charlotte Verroken, Sarah Collet, Bruno Lapauw, Guy T'Sjoen
Summary: This review discusses the impact of gender-affirming hormonal treatment (GAHT) on bone mass, structure, and metabolism in transgender adults and adolescents. It suggests that GAHT in transgender adults does not result in significant bone loss, while pubertal suppression in transgender adolescents affects bone development, with partial recovery observed after GAHT initiation. However, there is still a research gap in understanding fracture risk and other determinants of bone strength. Attention to bone health is especially important for adult and adolescent trans women, who have a relatively high prevalence of low bone mass before and after long-term GAHT. Strategies to optimize bone health include monitoring treatment compliance, ensuring adequate exposure to sex steroids, physical activity, sufficient vitamin D and calcium intake, and a healthy lifestyle. When risk factors for osteoporosis are present, DXA screening should be conducted with a low threshold, and treatment decisions should follow the same guidelines as the general population.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Neurosciences
Marie Coussens, Bruno Lapauw, Thiberiu Banica, Inge De Wandele, Verity Pacey, Lies Rombaut, Fransiska Malfait, Patrick Calders
Summary: This study evaluated the differences in physical impairment, muscle strength, muscle mass, and muscle density between patients with hypermobile Ehlers Danlos Syndrome (hEDS), hypermobile spectrum disorder (HSD), and healthy controls. The results showed no significant differences in physical functioning and muscle strength between individuals with hEDS and HSD. However, compared to the healthy controls, both patient groups had significantly lower physical functioning and muscle strength. Therefore, strength training is necessary for individuals with hEDS and HSD.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2022)