Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure

The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension

(2020) Biswajit Chowdhury et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects

(2020) Matthew Griffin et al.   CIRCULATION

Endogenous Activation of Glucagon-Like Peptide-1 Receptor Contributes to Blood Pressure Control

(2020) Flavia L. Martins et al.   HYPERTENSION

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

(2020) Milton Packer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

(2019) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis

(2019) Brendon L Neuen et al.   Lancet Diabetes & Endocrinology

Cardioprotection conferred by SGLT2 inhibitors: a renal proximal tubule perspective

(2019) Danúbia Silva dos Santos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Renoprotective effects of sodium-glucose cotransporter-2 inhibitors and underlying mechanisms

(2019) Naoki Kashihara et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

SGLT2 inhibition and kidney protection

(2018) Josselin Nespoux et al.   CLINICAL SCIENCE

A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor–dependent pathway after renal injury in mice

(2018) Yifan Zhang et al.   KIDNEY INTERNATIONAL

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

(2018) Stephen D. Wiviott et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renal sodium avidity in heart failure: from pathophysiology to treatment strategies

(2017) Wilfried Mullens et al.   EUROPEAN HEART JOURNAL

SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy

(2017) Xiaoxin X. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary Hypertension in Heart Failure

(2017) Marco Guazzi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis

(2017) Luciana C. Veiras et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

(2017) Bruce Neal et al.   NEW ENGLAND JOURNAL OF MEDICINE

High glucose augments angiotensinogen in human renal proximal tubular cells through hepatocyte nuclear factor-5

(2017) Juan Wang et al.   PLoS One

Angiotensin II counteracts the effects of cAMP/PKA on NHE3 activity and phosphorylation in proximal tubule cells

(2016) Renato O. Crajoinas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule

(2016) Chiara Ghezzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The kidney in heart failure: an update

(2015) Kevin Damman et al.   EUROPEAN HEART JOURNAL

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule

(2014) T. D. Pessoa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes

(2013) H. J. Lambers Heerspink et al.   DIABETES OBESITY & METABOLISM

Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure

(2011) Bruna H. Inoue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule

(2010) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY