Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Klaudia Cseh, Heiko Geisler, Kristina Stanojkovska, Julia Westermayr, Philipp Brunmayr, Dominik Wenisch, Natalie Gajic, Michaela Hejl, Martin Schaier, Gunda Koellensperger, Michael A. A. Jakupec, Philipp Marquetand, Wolfgang Kandioller
Summary: The main purpose of this study was to synthesize a new set of naphthoquinone-based ruthenium(II) arene complexes and understand their mode of action. The chemical structures and biological activities of these compounds were examined, and a positive correlation was found between cytotoxicity, lipophilicity, and cellular accumulation. This study provides important insights into the effects of these arene complexes.
Article
Chemistry, Inorganic & Nuclear
Milan M. Milutinovic, Angelina Z. Cakovic, Dusan Cocic, Eduard Rais, Roland Schoch, Bojana Simovic Markovic, Nebojsa Arsenijevic, Vladislav Volarevic, Snezana Jovanovic-Stevic, Jovana V. Bogojeski, Rene Wilhelm
Summary: Two neutral enantiopure arene-ruthenium(II) complexes with high affinity towards nucleophiles have been synthesized. The crystal structure of one of the complexes was characterized and it crystallizes in a monoclinic structure. The complexes also interact with DNA and protein, and exhibit significant cytotoxicity against various cancer cell lines.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Pavel Starha
Summary: The development of multinuclear homometallic biologically active complexes in modern bioinorganic chemistry offers increased therapeutic effects and variations in mechanism of action. Combining different metal centers within heterometallic complexes ensures unique modes of action, with comparisons between structurally similar analogues playing a key role in research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Denise Lovison, Dario Alessi, Lorenzo Allegri, Federica Baldan, Maurizio Ballico, Giuseppe Damante, Marilisa Galasso, Daniele Guardavaccaro, Silvia Ruggieri, Andrea Melchior, Daniele Veclani, Chiara Nardon, Walter Baratta
Summary: The paper describes a chiral ruthenium complex with high cytotoxic activity against various cell lines, particularly showing strong inhibition against the anaplastic thyroid cancer cell line 8505 C.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Abirami Arunachalam, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam
Summary: This study describes the synthesis and characterization of six new arene ruthenium(II) complexes containing biphenyl benzhydrazone ligands and evaluates their antiproliferative properties. The complexes demonstrated significant cytotoxicity against cancer cells and have the potential to be used as alternate anticancer drugs to platinum drugs.
Article
Biochemistry & Molecular Biology
Elena de la Torre-Rubio, Laura Munoz-Moreno, Ana M. Bajo, Maria-Selma Arias-Perez, Tomas Cuenca, Lourdes Gude, Eva Royo
Summary: Water-soluble half-sandwich ruthenium(II) polypyridyl-glycoconjugates have been synthesized and their behavior in water and interactions with DNA have been studied. These compounds bind DNA through minor groove binding, external electrostatic interactions, and a non-classical intercalation mechanism. They also exhibit cytotoxicity against prostate cancer cells and have anti-migratory and MMP-9 inhibitory activities.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dalila Iacopini, Jan Vanco, Sebastiano Di Pietro, Vittorio Bordoni, Stefano Zacchini, Fabio Marchetti, Zdenek Dvorak, Tomas Malina, Lorenzo Biancalana, Zdenek Travnicek, Valeria Di Bussolo
Summary: Glycoconjugation is a powerful strategy to enhance the anticancer activity of metal complexes. In this study, glycoconjugated ruthenium(II) p-cymene complexes were synthesized by modifying commercial arylphosphanes with carbohydrate-derived fragments. These complexes exhibited significant cytotoxicity against various cancer cell lines and showed potential as novel anticancer agents.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sayak Gupta, Jessica M. Vandevord, Lauren M. Loftus, Nicholas Toupin, Malik H. Al-Afyouni, Thomas N. Rohrabaugh, Claudia Turro, Jeremy J. Kodanko
Summary: The synthesis, chemical and biological characterization of seven Ru(II) polypyridyl complexes containing acetylacetonate (acac) ligands were studied. The compounds showed a range of cytotoxicities and selectivity in cancer and normal cell lines. Lipophilicity was found to have a moderate linear correlation with toxicities, and some Ru-acac compounds were found to induce apoptosis in MDA-MB-231 cells.
INORGANIC CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Andreia Valente, Ana Podolski-Renic, Isabella Poetsch, Nenad Filipovic, Oscar Lopez, Iztok Turel, Petra Heffeter
Summary: Drug resistance remains a major cause of cancer treatment failure, especially in the late stage of the disease. Metal and metalloid compounds offer the possibility to design fine-tuned drugs to overcome drug-resistant cancer cells. This review highlights the importance of platinum drugs in clinics and discusses strategies to reverse resistance to platinum drugs and multidrug resistance based on ABC efflux pumps.
DRUG RESISTANCE UPDATES
(2021)
Article
Chemistry, Multidisciplinary
Kanishka Sikligar, Steven P. Kelley, Gary A. Baker, Jerry L. Atwood
Summary: In this work, the solvothermal reaction of C-alkylpyrogallol[4]arene (alkyl = methyl, ethyl) in cesium containing N,N-dimethylformamide (DMF) yielded coordination networks with distinct cesium environments featuring dual coordination modes. These networks showcase a combination of O-coordination and π bonding with the C-alkylpyrogallol[4]arene receptor, suggesting the potential for further interesting architectures in alkali metal-incorporated systems.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Inorganic & Nuclear
Arabinda Muley, Kalai Selvan Karumban, Parth Gupta, Sadananda Kumbhakar, Bishnubasu Giri, Rajnikant Raut, Ashish Misra, Somnath Maji
Summary: Three versatile half-sandwich ruthenium(II) p-cymene complexes with substituted triazole ligands showed promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. The synthesized complexes exhibited significant cytotoxicity in lung and breast cancer cell lines with different IC50 values.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Article
Chemistry, Medicinal
Daphne Romani, Fabio Marchetti, Corrado Di Nicola, Massimiliano Cuccioloni, Chunmei Gong, Anna Maria Eleuteri, Agustin Galindo, Farzaneh Fadaei-Tirani, Massimo Nabissi, Riccardo Pettinari
Summary: A series of Ga(Q(n))(3) coordination compounds were synthesized and characterized through various techniques. Cytotoxicity studies showed interesting results in terms of selectivity and toxicity values compared with cisplatin. Mechanistic investigations revealed that the gallium(III) complexes induced cancer cell death through ferroptosis, triggering various cell death signals and altering cell redox homeostasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Polymer Science
Yury A. Belousov, Mikhail T. Metlin, Darya A. Metlina, Mikhail A. Kiskin, Ilya A. Yakushev, Trofim A. Polikovskiy, Ilya V. Taydakov, Andrei A. Drozdov, Fabio Marchetti, Claudio Pettinari
Summary: A new strategy for the easy polymerization of anionic [Ln(Q(cy))(4)](-) into two-dimensional layers of [AgLn(Q(cy))(4)](n) is proposed by binding the single molecular anions [Ln(Q(cy))(4)](-) to silver cations through coordination. The luminescent properties of [AgLn(Q(cy))(4)](n) have been studied, and it was found that LMCT quenching is effectively suppressed in the heterometallic [AgEu(Q(cy))(4)](n) polymer, explaining the low PLQY in [Eu(Q(cy))(4)](-). Sensibilization coefficients for H3O[Eu(Q(cy))(4)], [AgEu(Q(cy))(4)](n), and H3O[Sm(Q(cy))(4)] complexes were estimated via theoretical analysis and PLQY measurements.
Article
Biochemistry & Molecular Biology
Alessia Garufi, Riccardo Pettinari, Fabio Marchetti, Mara Cirone, Gabriella D'Orazi
Summary: Organometallic ruthenium (Ru)(II)-cymene complexes have potential pharmacological properties as alternative therapeutic agents. Polyphenols, such as curcumin and curcuminoids, also display beneficial properties in medicine, including chemoprevention. This study investigated the anticancer effect of a cationic Ruthenium (Ru)(II)-cymene Bisdemethoxycurcumin (Ru-bdcurc) complex, revealing that targeting the interconnection between the endoplasmic reticulum (ER)-resident chaperone GRP78/BiP and NRF2 pathways enhances the cytotoxic effect of Ru-bdcurc on colon cancer cells.
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Biochemistry & Molecular Biology
Sonila Xhafa, Laura Olivieri, Corrado Di Nicola, Riccardo Pettinari, Claudio Pettinari, Alessia Tombesi, Fabio Marchetti
Summary: In this study, a new synthetic protocol based on microwave-assisted synthesis was used to prepare higher yields of zinc and copper in MOFs with different ligands. The antibacterial activity of these MOFs was tested against Gram-negative and Gram-positive bacteria, and the results showed that they exhibited broad-spectrum activity and strong efficiency in inhibiting bacterial growth. The mechanism of action was found to be based on the surface contact of MOF particles with bacterial cells and the generation of reactive oxygen species.
Review
Chemistry, Physical
Patrizio Campitelli, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Anna Mauri, Simona Galli, Tongan Yan, Dahuan Liu, Jiaxin Dawn Duan, Subhadip Goswami, Giulia Tuci, Giuliano Giambastiani, Joseph T. Hupp, Andrea Rossin
Summary: The reaction of 3,5-diamino-4,4'-bis(1H-pyrazole) with copper(II) and nickel(II) acetates under solvothermal conditions produced four mixed-metal metal-organic frameworks. These frameworks have macroporous structures and high CO2 adsorption capacity. They were also tested as heterogeneous catalysts for CO2 electrochemical reduction, with Cu0.05Ni0.95 showing the best performance and producing CO and CH4 as the main reduction products.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Corrado Di Nicola, Fabio Marchetti, Alessia Tombesi, Sonila Xhafa, Patrizio Campitelli, Marco Moroni, Simona Galli, Riccardo Pettinari, Claudio Pettinari
Summary: Novel copper(ii) coordination polymers were synthesized and their thermal behavior and structural features were investigated. The nanoparticles showed potential antibacterial activity through a contact kill mechanism involving ROS production.
NEW JOURNAL OF CHEMISTRY
(2023)