期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 46, 期 7, 页码 1587-1591出版社
WILEY
DOI: 10.1002/eji.201646500
关键词
CD28; costimulation; CD8(+) T cell; T-cell memory
类别
资金
- NIAID NIH HHS [R01 AI093637] Funding Source: Medline
Rapid activation and proliferative expansion of specific CD8(+) memory T (CD8(+)T(M)) cells upon antigen re-encounter is a critical component of the adaptive immune response that confers enhanced immune protection. In this context, however, the requirements for costimulation in general, and CD28 signaling in particular, remain incompletely defined. In the current issue of the European Journal of Immunology, Frohlich et al. [Eur. J. Immunol. 2016. 46: 1644-1655] provide definitive evidence that optimal elaboration of CD8(+)T(M)-cell recall responses is indeed contingent on CD28 expressed by these cells. Here, we discuss the CD28 costimulation paradigm in its historical context and highlight some of the unresolved complexities pertaining to CD28-dependent interactions that shape CD8(+) T-cell phenotypes, functionalities, and recall reactivity.
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