Nitrosamine contamination in pharmaceuticals: threat, impact, and control

A Cautionary Tale: Quantitative LC-HRMS Analytical Procedures for the Analysis of N-Nitrosodimethylamine in Metformin

(2020) Jingyue Yang et al.   AAPS Journal

Pathways for N-nitroso compound formation: secondary amines and beyond

(2020) Rocio López-Rodríguez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Determination of N-nitrosodimethylamine and N-nitrosomethylethylamine in drug substances and products of sartans, metformin and ranitidine by precipitation and solid phase extraction and gas chromatography–tandem mass spectrometry

(2020) Hyun-Hee Lim et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The contamination of valsartan and other sartans, part 1: New findings

(2019) Fritz Sörgel et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Oral intake of ranitidine increases urinary excretion ofN-nitrosodimethylamine

(2016) Teng Zeng et al.   CARCINOGENESIS

Copper(ii)-catalyzed oxidative N-nitrosation of secondary and tertiary amines with nitromethane under an oxygen atmosphere

(2015) Norio Sakai et al.   CHEMICAL COMMUNICATIONS

Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice

(2015) R Tolba et al.   LABORATORY ANIMALS

Effect of oxidation on amine-based pharmaceutical degradation and N-Nitrosodimethylamine formation

(2015) Xiaofeng Wang et al.   WATER RESEARCH

NDMA formation kinetics from three pharmaceuticals in four water matrices

(2011) Ruqiao Shen et al.   WATER RESEARCH

Chloramination of nitrogenous contaminants (pharmaceuticals and pesticides): NDMA and halogenated DBPs formation

(2011) Julien Le Roux et al.   WATER RESEARCH

Radical Mechanisms in Nitrosamine- and Nitrosamide-Induced Whole-Genome Gene Expression Modulations in Caco-2 Cells

(2010) Dennie G. A. J. Hebels et al.   TOXICOLOGICAL SCIENCES

Demonstration of 20 pharmaceuticals and personal care products (PPCPs) as nitrosamine precursors during chloramine disinfection

(2010) Ruqiao Shen et al.   WATER RESEARCH

Formation of Formaldehyde Adducts in the Reactions of DNA and Deoxyribonucleosides with α-Acetates of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), andN-Nitrosodimethylamine (NDMA)

(2008) Guang Cheng et al.   CHEMICAL RESEARCH IN TOXICOLOGY