Review
Biochemistry & Molecular Biology
Siying Ren, Yue Chen, Likun Wang, Guofeng Wu
Summary: Intracerebral hemorrhage is a devastating form of stroke that induces cell death responsible for secondary brain injury. Iron-dependent cell death, known as ferroptosis, plays a crucial role in the occurrence and progression of intracerebral hemorrhage. Understanding and targeting the regulators and signaling pathways of ferroptosis could lead to potential treatments for intracerebral hemorrhage.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Neurosciences
Linqian Shao, Sichao Chen, Li Ma
Summary: This review discusses the pathways and effects of oxidative stress after ICH, as well as its relationship with inflammation and autophagy, and explores current antioxidant therapy for ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Peripheral Vascular Disease
Farina Mohamad Yusoff, Tatsuya Maruhashi, Ki-ichiro Kawano, Ayumu Nakashima, Kazuaki Chayama, Satoshi Tashiro, Kazuhiko Igarashi, Yukihito Higashi
Summary: The study demonstrates that genetic ablation of Bach1 accelerates blood flow recovery and angiogenesis in ischemic hindlimbs, while reducing oxidative stress. Bach1 may serve as a potential therapeutic target for patients with peripheral arterial disease, by improving angiogenesis and reducing oxidative stress.
MICROVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Reng Ren, Yuanjian Fang, Prativa Sherchan, Qin Lu, Cameron Lenahan, John H. Zhang, Jianmin Zhang, Jiping Tang
Summary: The study demonstrates that kynurenine/AHR is involved in the pathological processes of mitochondria-mediated cell death and free radical accumulation after intracerebral hemorrhage. Inhibition of AHR can alleviate oxidative stress and neuronal apoptosis, providing neuroprotective effects.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Neurosciences
Zhimin Sun, Qiyao Li, Xiaopeng Li, Yunpeng Shi, Chengrui Nan, Qianxu Jin, Xiaoyan Wang, Yayu Zhuo, Zongmao Zhao
Summary: This study demonstrates that CK2 phosphorylates NR2B, down-regulates the expression of NR2B, and interferes with the interaction between NR2B and PSD95, thus alleviating inflammatory reactions, inhibiting neuronal apoptosis, and reducing oxidative stress after ICH. CK2 and NR2B may be new potential therapeutic targets for the treatment of ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Fei Wang, Wu-lin Li, Li-juan Shen, Ting-ting Jiang, Jian-jun Xia, Da-li You, Shan-you Hu, Li Wang, Xiao Wu
Summary: This study investigated the protective role of crocin in brain injury caused by intracerebral hemorrhage (ICH) and identified its mechanism. The results showed that crocin can alleviate ICH-induced brain edema and neurological deficits and exert its effect by inhibiting ferroptosis.
NEUROTOXICITY RESEARCH
(2022)
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Loboda, Jozef Dulak
Summary: Skeletal muscles have a robust regenerative capacity. The role of NRF2 in muscle regeneration and its potential therapeutic applications need further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Julia Masomi-Bornwasser, Elena Kurz, Christina Frenz, Jan Schmitt, Dominik M. A. Wesp, Jochem Koenig, Johannes Lotz, Florian Ringel, Thomas Kerz, Harald Krenzlin, Naureen Keric
Summary: This study found that higher levels of SOD and GSH-Px in plasma were associated with better clinical outcomes in patients with ICH, while higher plasma TAS and CSF MDA were linked to unfavorable outcomes. Larger ICH volume was positively correlated with a worse outcome at week six.
Review
Immunology
Yan Zhang, Suliman Khan, Yang Liu, Guofeng Wu, V. Wee Yong, Mengzhou Xue
Summary: This article discusses the sources and possible molecular mechanisms of oxidative stress in causing brain injury in intracerebral hemorrhage (ICH), as well as anti-oxidative stress strategies to alleviate the devastation of ICH.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Liping Zou, Guiping Cheng, Chengcheng Xu, Heyu Liu, Yingying Wang, Nianyu Li, Xiaorong Fan, Changhong Zhu, Wei Xia
Summary: CuNPs induce oxidative stress in human ovarian granulosa cells, possibly through the MAPK14-Nrf2 signaling pathway to induce HO-1 expression, but HO-1 can protect cells from oxidative stress induced by CuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Akihiro Yachie
Summary: HO-1 is crucial in protecting tissues and organs from oxidative stress and excessive inflammatory reactions. Deficiency in HO-1 leads to dysfunction in monocytes, macrophages, and endothelial cells, resulting in systemic inflammatory response syndrome. Therapeutic induction of HO-1 production through pharmacological intervention shows promise in controlling inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
