Review
Biochemistry & Molecular Biology
Rebecca Katharina Masanetz, Juergen Winkler, Beate Winner, Claudia Guenther, Patrick Suess
Summary: This review summarizes the pathogenesis of depression and anxiety in inflammatory bowel disease (IBD), including the cascade along the gut-immune-brain axis, neuroinflammatory changes, and the role of intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Linshan Duan, Shuyu Cheng, Long Li, Yanling Liu, Dan Wang, Guoyan Liu
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation caused by various factors, with Crohn's disease and ulcerative colitis being the two major types. Most commonly used drugs for IBD have adverse reactions and limited long-term efficacy, leading to challenges in treating patients. Research suggests that natural compounds with anti-inflammatory activities could offer potential therapeutic strategies for IBD.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Summary: Patients with inflammatory bowel disease (IBD) have higher rates of depression, possibly due to inflammation in the central nervous system. Intestinal inflammation and dysfunction may lead to reduced intestinal permeability, allowing enterotoxins to enter the bloodstream and affect non-intestinal tissues like the brain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Gastroenterology & Hepatology
Katsuyoshi Ando, Mikihiro Fujiya, Kenji Watanabe, Sakiko Hiraoka, Hisashi Shiga, Shinji Tanaka, Hideki Iijima, Tsunekazu Mizushima, Taku Kobayashi, Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Takehiro Torisu, Kiyonori Kobayashi, Masaaki Higashiyama, Toshiro Fukui, Takashi Kagaya, Motohiro Esaki, Shunichi Yanai, Daiki Abukawa, Makoto Naganuma, Satoshi Motoya, Masayuki Saruta, Shigeki Bamba, Makoto Sasaki, Kazuhiko Uchiyama, Katsuyuki Fukuda, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu, Masahiro Iizuka, Mamoru Watanabe, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: The study investigated the mortality and risk factors of TE in IBD patients in Japan. The incidence of TE among 31,940 IBD patients was 1.89%, with 10.7% developing severe TE and 1.0% TE-associated mortality. Ischemic heart disease was the only risk factor for severe ATE and ATE-associated death, while age, VTE location, and disease severity were independent risk factors for severe VTE and VTE-associated death.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Liat S. Fine, Shiyun Zhu, Aida Shirazi, Jeffrey K. Lee, Fernando S. Velayos
Summary: Patients with inflammatory bowel disease (IBD) are at high risk of malnutrition. This study evaluated the association between an electronic medical record-derived modified malnutrition risk score and IBD-related hospitalization, surgery, and venous thromboembolism. The results showed a significant association between malnutrition risk and these adverse outcomes.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ashwin N. Ananthakrishnan, Gilaad G. Kaplan, Charles N. Bernstein, Kristin E. Burke, Paul J. Lochhead, Alexa N. Sasson, Manasi Agrawal, Jimmy Ho Tuan Tiong, Joshua Steinberg, Wolfgang Kruis, Flavio Steinwurz, Vineet Ahuja, Siew C. Ng, David T. Rubin, Jean-Frederic Colombel, Richard Gearry
Summary: Environmental and lifestyle factors are crucial in the development of Crohn's disease and ulcerative colitis. A group of international experts have provided a series of consensus statements for the management of inflammatory bowel disease (IBD), including recommendations on smoking cessation, mental health screening, regular physical activity, and evidence-based dietary approaches.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Cell & Tissue Engineering
D. Xu, C. Ding, T. Cheng, C. Yang, X. Zhang
Summary: This study investigated whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes compared to those without IBD. The findings suggest that IBD is associated with an increased risk of postoperative complications, including overall complications, medical complications, surgical complications, and 90-day readmissions. Patients with IBD also tend to have longer hospital stays and higher costs of care.
BONE & JOINT RESEARCH
(2023)
Article
Pediatrics
Jan De Laffolie, Antje Ballauff, Stefan Wirth, Carolin Blueml, Frank Risto Rommel, Martin Classen, Martin Laass, Thomas Lang, Almuthe Christina Hauer, CEDATA GPGE Study Grp
Summary: Among pediatric patients with inflammatory bowel disease (IBD), there is a significantly increased risk of thromboembolism (TE). Ulcerative colitis (UC) patients have a higher risk compared to Crohn's disease (CD) patients. TE often occurs during active disease, and some patients experience severe cerebral and limb involvement. Evaluating and preventing these risk factors is crucial for the management of pediatric IBD.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pharmacology & Pharmacy
Xiaomei Wang, Guoliang Zhou, Wanwan Zhou, Xin Wang, Xiao Wang, Chenggui Miao
Summary: Inflammatory bowel disease (IBD) is a type of chronic relapsing inflammatory disease with unclear pathogenesis involving environmental factors, genetic factors, intestinal microbiota disorder, and abnormal immune responses. Exosomes, with sizes ranging from 30-150 nm, are involved in IBD pathogenesis by mediating intercellular communication and regulating cell activity through non-coding RNAs, proteins, and lipids. Understanding the roles of exosomes in IBD may offer new diagnostic markers and therapeutic targets.
Article
Multidisciplinary Sciences
Wang Shujun, Zhang Huijie, Bai Xia, Wang Hongjian
Summary: Cerebral venous sinus thrombosis is a rare complication of inflammatory bowel disease, and early diagnosis along with prompt treatment is crucial for better prognosis. Anemia, low albumin, and elevated d-dimer are independent predictors of CVST in IBD patients.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Hua Zhang, Xuehong Wang
Summary: This study evaluated the risk factors influencing the incidence of venous thromboembolism in patients with inflammatory bowel disease, finding that aging, steroid therapy, surgery, and ulcerative colitis are associated with higher risks, while female gender did not increase the incidence of venous thromboembolism in these patients.
FRONTIERS IN MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Chi-Pin James Wang, Min Ji Byun, Se-Na Kim, Wooram Park, Hee Ho Park, Tae-Hyung Kim, Jung Seung Lee, Chun Gwon Park
Summary: Inflammatory bowel diseases (IBDs) are gastrointestinal inflammatory disorders featuring chronic intestinal inflammation. Novel biomaterial-based platforms have been developed to deliver drugs to damaged sites with increased efficacy and reduced side effects in IBD treatments.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Gastroenterology & Hepatology
Susanna Scharrer, Christian Primas, Sabine Eichinger, Sebastian Tonko, Maximilian Kutschera, Robert Koch, Andreas Blesl, Walter Reinisch, Andreas Mayer, Thomas Haas, Thomas Feichtenschlager, Harry Fuchssteiner, Pius Steiner, Othmar Ludwiczek, Reingard Platzer, Wolfgang Miehsler, Wolfgang Tillinger, Sigrid Apostol, Alfons Schmid, Karin Schweiger, Harald Vogelsang, Clemens Dejaco, Harald Herkner, Gottfried Novacek
Summary: The risk of major bleeding is increased in patients with inflammatory bowel disease during anticoagulation, with exposure to anticoagulation and ulcerative colitis as independent risk factors for major bleeding events. This risk may be outweighed by the high VTE recurrence rate in patients with IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Cell Biology
Wei Zhou, Haiyin Zhang, Yibin Pan, Yanwu Xu, Yongqing Cao
Summary: The study explored the role of circular RNAs (circRNAs) in understanding the biological mechanisms of mesalazine treatment for IBD. It identified key circRNA-miRNA-mRNA pathways associated with the treatment response, providing new insights into IBD pathogenesis.
Article
Hematology
Ikechukwu Achebe, Chimezie Mbachi, Pedro Palacios, Yuchen Wang, Jennifer Asotibe, Aaron Ofori-Kuragu, Seema Gandhi
Summary: Patients with inflammatory bowel disease (IBD) and colon cancer (CC) who develop venous thromboembolism (VTE) have unique procoagulant properties that differ from those with IBD or CC alone, as indicated by predictors of VTE in a study using Nationwide Inpatient Sample data from 2005-2014.
THROMBOSIS RESEARCH
(2021)