Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial

(2021) Harpreet S. Bajaj et al.   DIABETES CARE

A Randomized, Open-Label Comparison of Once-Weekly Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100

(2021) Ildiko Lingvay et al.   DIABETES CARE

237-OR: Insulin Icodec: An Insulin Analog Suited for Once-Weekly Dosing in Type 2 Diabetes

(2020) ULRIKE HÖVELMANN et al.   DIABETES

Molecular engineering of safe and efficacious oral basal insulin

(2020) Frantisek Hubálek et al.   Nature Communications

Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment

(2020) Julio Rosenstock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

(2020) Thomas B. Kjeldsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy and safety of oral basal insulin versus subcutaneous insulin glargine in type 2 diabetes: a randomised, double-blind, phase 2 trial

(2019) Inge B Halberg et al.   Lancet Diabetes & Endocrinology

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2018) Melanie J. Davies et al.   DIABETOLOGIA

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

(2015) Tine N. Vinther et al.   JOURNAL OF PEPTIDE SCIENCE

Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability

(2015) Tine N. Vinther et al.   PROTEIN SCIENCE

Ligand-Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec

(2012) Dorte B. Steensgaard et al.   BIOCHEMISTRY

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

(2012) Ib Jonassen et al.   PHARMACEUTICAL RESEARCH

Insulin analog with additional disulfide bond has increased stability and preserved activity

(2012) Tine N. Vinther et al.   PROTEIN SCIENCE

Patient perspectives on once-weekly medications for diabetes

(2010) W. H. Polonsky et al.   DIABETES OBESITY & METABOLISM

Comparison of a Luminescent Oxygen Channeling Immunoassay and an ELISA for detecting Insulin Aspart in human serum

(2009) Signe Beck Petersen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Importance of the Solvent-Exposed Residues of the Insulin B Chain α-Helix for Receptor Binding†

(2008) Tine Glendorf et al.   BIOCHEMISTRY