Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Hongyu Wu, Wen Liu, Minyue Yin, Lu Liu, Shuting Qu, Wei Xu, Chunfang Xu
Summary: This study aimed to develop a practical prediction model for the assessment of lymph node metastasis (LNM) in patients with early gastric cancer (EGC) based on preoperative pathological data and inflammatory or nutrition-related indicators. The study analyzed the clinicopathological characteristics of 1,061 EGC patients and constructed a nomogram using the LASSO algorithm and multivariate logistic regression. The model included depth of invasion, tumor size, degree of differentiation, and platelet-to-lymphocyte ratio (PLR) as independent risk factors, and showed good performance in both internal and external validations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Cinthia Minatel Riguetto, Icleia Siqueira Barreto, Frederico Fernandes Ribeiro Maia, Ligia Vera Montali da Assumpcao, Denise Engelbrecht Zantut-Wittmann
Summary: The study focused on examining the relationships of NLR, PLR, and MLR with clinicopathological characteristics of patients with differentiated thyroid cancer. PLR was higher in patients with distant metastasis, while MLR was associated with active disease. Cut-off values of NLR, PLR, and MLR were able to differentiate distant metastasis from lymph node metastasis with good sensitivity and accuracy.
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
HuiFang Lei, ShuXia Xu, XiaoDan Mao, XiaoYing Chen, YaoJia Chen, XiaoQi Sun, PengMing Sun
Summary: This study found that a high SII in EC patients was associated with LNM, and in combination with CA125, CA153, and LVSI could be used for diagnosing LNM. Additionally, SII was identified as a predictor for MI and higher pathological grade in young premenopausal EC patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Keiichiro Kumamoto, Takashi Tasaki, Koji Ohnishi, Michihiko Shibata, Shohei Shimajiri, Masaru Harada, Yoshihiro Komohara, Toshiyuki Nakayama
Summary: The activation of immune cells in regional lymph nodes is associated with lymphocyte infiltration in primary cancer tissues, impacting cancer-specific survival in patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuma Wada, Masaaki Nishi, Kozo Yoshikawa, Chie Takasu, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Toshiaki Yoshimoto, Mitsuo Shimada
Summary: This study reveals the clinical importance of evaluating the lymph node response to neoadjuvant chemotherapy in predicting survival outcomes for patients with gastric cancer.
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Cell Biology
Yu Mei, Shuo Wang, Tienan Feng, Min Yan, Fei Yuan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: The study established a nomogram for predicting lymph node metastasis in early gastric cancer, with age, tumor size, submucosal invasion, histological subtype, and HER2 positivity identified as independent risk factors. The model showed good performance in both internal and external validation, with the prediction model providing a higher net benefit for guiding treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Noriyuki Nishiwaki, Tomoyuki Irino, Keiichi Fujiya, Satoshi Kamiya, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Kimihide Kusafuka, Masanori Terashima
Summary: The study aimed to clarify the clinicopathological characteristics and prognostic relevance of extra-nodal metastasis (ENM) in gastric cancer patients undergoing curative gastrectomy. Results showed that ENM was an independent prognostic factor with a prognostic significance different from that of lymph node metastasis.
Article
Cell Biology
Xinying Guo, Jie Gu, Anwei Xue, Shushu Song, Bo Liu, Xiaodong Gao, Jianxin Gu, Lei Chang, Yuanyuan Ruan
Summary: Endoscopic surgery is commonly used for EGC treatment, but LNM remains a significant risk factor for relapse. The study found that GNE expression is down-regulated in EGC patients with LNM. Combining GNE expression with other predictive factors can improve the accuracy of LNM prediction in EGC patients.
Article
Oncology
Yoon Jung Oh, Deok Hee Kim, Bang Wool Eom, Hong Man Yoon, Young-Woo Kim, Keun Won Ryu
Summary: A retrospective study of 1038 patients with proximal advanced gastric cancer undergoing total gastrectomy found that prophylactic splenic hilar lymph node dissection without splenectomy did not improve long-term survival outcomes. Therefore, this procedure may not be essential for patients with proximal advanced gastric cancer as well as those with greater curvature involvement or Borrmann type IV disease.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Oh Jeong, Han Hong Lee, Hoon Hur, Hyoung-Il Kim
Summary: The study aimed to evaluate the impact of no.10 lymph node dissection on the long-term survival of patients with Borrmann type 4 gastric cancer. The results showed that patients who underwent no.10 lymph node dissection had better survival rates compared to those without dissection. Therefore, it is recommended to perform no.10 lymph node dissection during total gastrectomy for patients with Borrmann type 4 gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yuan Tian, Yue Pang, Pei-Gang Yang, Hong-Hai Guo, Yang Liu, Ze Zhang, Ping-An Ding, Tao Zheng, Yong Li, Li-Qiao Fan, Zhi-Dong Zhang, Dong Wang, Xue-Feng Zhao, Bi-Bo Tan, Yu Liu, Qun Zhao
Summary: This study investigated the influencing factors and prognosis of micro lymph node metastasis in gastric cancer, and found that micro lymph node metastasis is an independent risk factor for poor prognosis in gastric cancer patients.
Article
Multidisciplinary Sciences
Ying Xiong, Yuanyuan Yong, Yanhua Wang
Summary: This study aimed to investigate the clinical importance of the hemoglobin, albumin, lymphocyte, and platelet (HALP) indexes in predicting lymph node metastasis and recurrence of endometrial cancer. The results showed that the HALP score was significantly associated with differentiation, myometrial invasion, and lymph node metastasis in endometrial cancer patients.
Article
Medicine, Research & Experimental
Xiangwei Sun, Jianfeng Xu, Xiaodong Chen, Weiteng Zhang, Wenjing Chen, Ce Zhu, Jing Sun, Xinxin Yang, Xiang Wang, Yingying Hu, Yiqi Cai, Xian Shen
Summary: This study found that in gastric cancer patients with normal BMI, those with sarcopenia are more likely to have postoperative complications and lower survival rates. Sarcopenia is an independent predictor in these patients.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Immunology
Zhonglin Ni, Dong Xing, Teming Zhang, Ning Ding, Dan Xiang, Zhiguang Zhao, Jinmiao Qu, Changyuan Hu, Xian Shen, Xiangyang Xue, Jie Zhou
Summary: The study found that B cell infiltration, especially class-switched memory B cells and plasma cells, in gastric cancer has a significant impact on tumor progression and prognosis. High levels of CD20+ B cell infiltration were significantly associated with improvements in overall survival and disease-free survival.
IMMUNOLOGIC RESEARCH
(2021)
Article
Oncology
Sian Chen, Chenbin Chen, Yuanbo Hu, Ce Zhu, Xiaozhi Luo, Lizhu Wang, Xiang Wang, Xiangwei Sun, Xiaodong Chen, Wangkai Xie, Han Lou, Xielin Huang, Chao Li, Jun Xu, Xiangyang Xue, Xian Shen
Summary: The study established a 3D culturing platform to accurately predict drug responses for gastric cancer. By evaluating cell proliferation, viability, and apoptosis markers, differential sensitivities to chemotherapeutics across different patient-derived tissues were identified, enabling personalized medication plans. This rapid, cost-effective, scalable, and reproducible protocol for GC tissue culture can greatly impact future oncological research.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Li-Bin Xu, Ming-Ming Shi, Ze-Xin Huang, Wei-Teng Zhang, Hui-Hui Zhang, Xian Shen, Xiao-Dong Chen
Summary: Diagnosis of malnutrition based on the GLIM criteria is effective in predicting adverse postoperative clinical outcomes in patients with gastric cancer, and there is moderate agreement between GLIM criteria and PG-SGA in diagnosing malnutrition.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Oncology
Chao Chen, Sian Chen, Zheng Han, Wangkai Xie, Teming Zhang, Chenchen Mao, Liang Zhang, Xiangwei Sun, Terry Kwok, Xian Shen, Xiangyang Xue
Summary: The study aimed to explore the role of HCMV and H. pylori co-infection in gastric cancer. PCR analysis of 134 patients revealed that some patients were co-infected with both HCMV and H. pylori. The results showed that H. pylori infection was independently associated with lymphatic metastasis, while HCMV-/H. pylori(+) co-infection was an independent risk factor for advanced lymphatic metastasis.
Article
Oncology
Zhonglin Wang, Jian Yu, Shangrui Rao, Zhe Lin, Zhongliang Pan, Xian Shen
Summary: Endoscopic thyroidectomy is widely accepted for treating thyroid diseases, with acceptable complication rates. Risk factors for complications include thyroid carcinoma, operation time over 150 minutes, and surgeries before 2017. Continuous improvement in endoscopic technology can help prevent and reduce complications.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Sisi Ye, Yuanbo Hu, Chenbin Chen, Sian Chen, Xinya Tong, Huanbo Zhu, Bo Deng, Xianjing Hu, Xiangwei Sun, Xiadong Chen, Xinyu Shi, Ruihong Gu, Wangkai Xie, Gangqiang Guo, Dong Xing, Xian Shen, Xiangyang Xue, Shurong Shen
Summary: The US31 gene expression is significantly associated with tumor size and distant metastasis in gastric cancer patients, and higher US31 expression indicates better overall survival. Overexpression of US31 inhibits the proliferation, migration, and invasion of GC cells, and it also regulates the tumor immune microenvironment. RNA sequencing and qPCR confirm that US31 promotes immune activation and secretion of inflammatory cytokines, suggesting a potential prognostic factor for GC and a new immunotherapy strategy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biophysics
Yanan Wang, Yanan Li, Lingyun He, Baiping Mao, Sian Chen, Vanessa Martinez, Xiaoling Guo, Xian Shen, Baohua Liu, Chao Li
Summary: The study found that the esterified alginate-curcumin conjugate exhibited effective anti-inflammatory effects in Raw 264.7 cells, and after oral administration in animals, the majority reached the colon rapidly and released curcumin, effectively reducing colonic inflammation and tissue damage. The curcumin release triggered by commensal flora shows great potential for ulcerative colitis treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Bujian Pan, Weiteng Zhang, Wenjing Chen, Jingwei Zheng, Xinxin Yang, Jing Sun, Xiangwei Sun, Xiaodong Chen, Xian Shen
Summary: The study aimed to develop a radiomic nomogram for preoperative identification of serosal invasion in gastric cancer patients. They found that the radiologic tumor invasion index based on splenic imaging combined with other factors accurately predicts serosal invasion, aiding in treatment decisions and saving time in the diagnostic process.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mingdong Lu, Bin Zhao, Mengshan Liu, Le Wu, Yingying Li, Yingna Zhai, Xian Shen
Summary: SETD2 mutation leads to higher tumor mutation burden and microsatellite instability, affects the transcription of immune-related genes, and is associated with favorable clinical outcomes in cancer patients treated with immune checkpoint inhibitors.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Zhiyuan Chen, Zheng Han, Han Nan, Jianing Fan, Jingfei Zhan, Yu Zhang, He Zhu, Yu Cao, Xian Shen, Xiangyang Xue, Kezhi Lin
Summary: This study identified a novel PRGs signature that could be used to predict the prognosis of COAD patients, which might provide a new therapeutic target for the treatment of COAD patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xiao-Dong Chen, Wen-Jing Chen, Ze-Xin Huang, Li-Bin Xu, Hui-Hui Zhang, Ming-Ming Shi, Yi-Qi Cai, Wei-Teng Zhang, Zhao-Shen Li, Xian Shen
Summary: This study found that sarcopenia features extracted from CT can be used to predict long-term survival and short-term complications of GC patients after surgery, and their accuracy has been validated by training and validation groups.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Jiante Li, Xinxin Yang, Xiang Wang, Yiwei Jiang, Zhonglin Wang, Xian Shen, Zhaoshen Li
Summary: This study designed a standardized index of the postoperative/preoperative platelet ratio to predict the prognosis of gastric cancer. The results showed that the postoperative/preoperative platelet ratio had good performance in predicting mortality and had good predictive value and clinical benefit.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Linqian Hou, Fei Gong, Bo Liu, Xiaoyuan Yang, Linfu Chen, Guangqiang Lie, Yuehan Gong, Chao Liang, Nailin Yang, Xian Shen, Zhuang Liu, Liang Cheng
Summary: In this study, we developed a novel and effective orally-administered nanoplatform based on titanium carbide MXene for targeted treatment of inflammatory bowel disease. The nanoplatform showed excellent ROS-scavenging abilities and specifically adsorbed onto inflamed colon tissue, leading to efficient therapy and symptom alleviation. Additionally, the nanoplatform promoted wound healing and functional vessel formation.
Article
Oncology
Chenchen Mao, Xiaodong Chen, Xiangwei Sun, Xiang Wang, Ce Zhu, Wenjing Chen, Xiangyang Xue, Xian Shen
Summary: This study compared the short- and long-term outcomes of gastric cancer patients with visceral obesity who underwent laparoscopic gastrectomy or open gastrectomy. The results showed that laparoscopic gastrectomy reduced overall complications and postoperative hospital stays, as well as improved long-term overall survival compared to open radical gastrectomy in patients with visceral obesity.
