Article
Computer Science, Information Systems
Rito Clifford Maswanganyi, Chunling Tu, Pius Adewale Owolawi, Shengzhi Du
Summary: This study investigates factors affecting the poor performance of EEG-BCI, including attention level, IC selection, inter-session variability, inter-subject variability, and classification methods. Results show that IC selection has an effect on IDR, and higher alpha rhythm corresponds to lower concentration level. Variability within sessions significantly decreases intention detection rate.
Article
Oncology
Aprajita Mall, Preety Negi, Ashwin Oommen Philip, Pamela A. Kingsley
Summary: This study evaluated the response to induction chemotherapy in inoperable locally advanced head and neck cancer patients. The results showed a complete response rate of 57.7% with induction chemotherapy, with younger patients having a better response. However, a higher grade of radiation-induced mucositis was observed in patients receiving three cycles of induction chemotherapy (ICT) and aged over 50 years.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Clinical Neurology
Ming Zhong, Carolina Cywiak, Abigael C. Metto, Xiang Liu, Chunqi Qian, Galit Pelled
Summary: This study aimed to identify protocols combining sensory stimulation with repetitive transcranial magnetic stimulation (rTMS) to induce changes in fMRI activation maps in the rat's primary somatosensory cortex (S1). The results showed that pairing 10 Hz forepaw stimulation with 10 Hz rTMS for five consecutive days led to the greatest increases in fMRI responses compared to other stimulation protocols.
Article
Neurosciences
Thomas Bazeille, Elizabeth DuPre, Hugo Richard, Jean-Baptiste Poline, Bertrand Thirion
Summary: This study benchmarks five functional alignment methods and finds that functional alignment generally improves inter-subject decoding accuracy, with the best performing methods being dependent on the research context. Specifically, SRM and Optimal Transport perform well at both the region-of-interest level of analysis as well as at the whole-brain scale when aggregated through a piecewise scheme.
Article
Psychology, Biological
Colin Hawco, Jennifer K. E. Steeves, Aristotle N. Voineskos, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: By analyzing an existing dataset, researchers found that using more trials in concurrent TMS-fMRI experiments can lead to reliable spatial changes in brain activity, especially in localized regions.
Article
Multidisciplinary Sciences
Akira Yamashita, Takenobu Murakami, Noriaki Hattori, Ichiro Miyai, Yoshikazu Ugawa
Summary: The study demonstrated that PCMS with supramaximal PNS intensity increased CMEP amplitude, and its facilitatory effect was greater than those of weaker PNS intensities for PCMS. Sham TMS with supramaximal PNS showed no changes in CMEP after intervention. The PNS intensity influences the magnitude of synaptic plasticity induction between CSTs and SMs at the spinal level, with supramaximal intensity being the most effective for inducing long-term potentiation-like effects.
Review
Clinical Neurology
G. Darmani, T. O. Bergmann, K. Butts Pauly, C. F. Caskey, L. de Lecea, A. Fomenko, E. Fouragnan, W. Legon, K. R. Murphy, T. Nandi, M. A. Phipps, G. Pinton, H. Ramezanpour, J. Sallet, S. N. Yaakub, S. S. Yoo, R. Chen
Summary: Transcranial ultrasound stimulation (TUS) has the potential to alter neural circuits non-invasively in both animals and humans. Unlike other non-invasive brain stimulation methods, TUS can focus on both cortical and deep brain targets with unprecedented spatial resolution. The neuromodulatory effects of TUS are derived from the interaction of ultrasound waves with neuronal membranes, resulting in changes in excitability and firing rate. After years of research, TUS is now being applied in human studies and can be assessed using non-invasive brain mapping techniques. This review provides a comprehensive overview of the principles, mechanisms, effects, and potential applications of TUS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Engineering, Multidisciplinary
Kunkun Zhao, Zhisheng Zhang, Haiying Wen, Alessandro Scano
Summary: The study assesses intra-subject and inter-subject variability in multi-directional reaching movements using muscle synergies, revealing lower intra-subject variability than inter-subject variability and confirming shared underlying control structures. Muscle synergies are found to be a valuable tool for quantifying variability at the muscle level, with both intra-subject and inter-subject similarity higher than random matching. The study deepens understanding of muscle synergy-based motor function assessment and rehabilitation applications, highlighting their applicability to real scenarios.
Article
Clinical Neurology
Lipeng Ning, Yogesh Rathi, Tracy Barbour, Nikos Makris, Joan A. Camprodon
Summary: This study utilized novel dMRI analysis to investigate microstructural changes related to rTMS treatment response in 21 MDD patients, finding that rTMS significantly affected the white matter microstructure in the anterior-medial prefrontal fiber bundles, while changes in lateral prefrontal tracts were correlated with treatment response. Further research with larger datasets is needed to fully understand the impact of rTMS on structural connectivity in MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Nabila Brihmat, Didier Allexandre, Soha Saleh, Jian Zhong, Guang H. Yue, Gail F. Forrest
Summary: There is a growing interest in using non-invasive stimulation interventions, such as repetitive transcranial magnetic stimulation (rTMS), to improve functional outcomes and recovery after spinal cord injury (SCI). This scoping review focuses on the stimulation parameters used in 20 rTMS protocols and explores their potential associations with observed effects. Future studies should consider timing, intervention duration, and dosage in relation to the stage, level, and severity of the injury. More real vs. sham rTMS studies with similar designs and replication information are needed to establish a significant level of evidence for the use of rTMS in SCI.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Audiology & Speech-Language Pathology
Donguk Lee, James D. Lewis
Summary: The objective of this study was to quantify the inter-subject variability in the dependence of the medial-olivocochlear reflex (MOCR) on noise bandwidth. The results showed that the dependence of MOCR-induced otoacoustic emission (OAE) magnitude and phase shifts on activator bandwidth could be well approximated using a linear model.
Article
Multidisciplinary Sciences
P. O. Boucher, R. A. Ozdemir, D. Momi, M. J. Burke, A. Jannati, P. J. Fried, A. Pascual-Leone, M. M. Shafi, Emiliano Santarnecchi
Summary: In this study, the effects of continuous TBS and intermittent TBS protocols on corticospinal excitability were compared over time, with results showing varying effects on motor evoked potentials. However, these effects were generally diminished in repeat visits. The findings challenge the efficacy and reliability of TBS protocols, highlighting the need to consider sham effects when evaluating TBS outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Fulin Wei, Xueyuan Xu, Tianyuan Jia, Daoqiang Zhang, Xia Wu
Summary: Individual differences present a challenge in motor imagery (MI) decoding. Multi-source transfer learning (MSTL) is a promising approach to reduce these differences. In this study, we propose a method called multi-source transfer joint matching (MSTJM) and weighted MSTJM (wMSTJM) to align data distribution between subject pairs and improve MI-BCI accuracy. Our framework outperformed state-of-the-art methods by at least 4.24% and 2.62%. This has potential implications for practical applications of MI-BCI.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Clinical Neurology
Ke Zeng, Ghazaleh Darmani, Anton Fomenko, Xue Xia, Stephanie Tran, Jean-Francois Nankoo, Yazan Shamli Oghli, Yanqiu Wang, Andres M. Lozano, Robert Chen
Summary: Transcranial ultrasound stimulation (TUS) has been shown to effectively induce cortical plasticity in human subjects, with the potential for neuromodulation treatment for neurological and psychiatric disorders, as well as advancing neuroscience research. This study demonstrated the efficacy of TUS in increasing corticospinal excitability and modulating intracortical inhibition and facilitation in the motor cortex.
ANNALS OF NEUROLOGY
(2022)
Article
Education & Educational Research
Yufeng Ke, Shuang Liu, Long Chen, Xiashuang Wang, Dong Ming
Summary: This study investigates the lasting neurophysiological effects of multi-session transcranial direct current stimulation (tDCS) combined with working memory training (WMT). The results show that multi-session tDCS enhances the behavioral benefits of WMT and facilitates sustained improvements in neural efficiency.
NPJ SCIENCE OF LEARNING
(2023)
Article
Neurosciences
Janine Kesselheim, Mitsuaki Takemi, Lasse Christiansen, Anke Ninija Karabanov, Hartwig Roman Siebner
Summary: This study investigated whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. The results showed that multipulse TMSHAND at individual peak latency and trough latency facilitated MEP amplitudes and reduced resting motor threshold (RMT). This facilitation may be related to I-wave periodicity and slower-conducting indirect pyramidal tract projections, respectively.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Allan Lohse, Annemette Lokkegaard, Hartwig R. Siebner, David Meder
Summary: Impulsivity refers to acting prematurely or without forethought, and it is a major issue in many neuropsychiatric disorders. The pre-supplementary motor area (pre-SMA) may play a role in inhibitory control and impulsivity. In this study, low-frequency rTMS of the pre-SMA was found to modulate task-related engagement and influence risky choice behavior during sequential gambling, providing evidence for a causal link between pre-SMA activity and impulsive risk-taking behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jacob Talbot, Henrik Lundell, Lisbet Marstrand, Camilla Gobel Madsen, Malene Bredahl Hansen, Hartwig Roman Siebner, Finn Sellebjerg, Helene Hojsgaard Chow, Helle Bach Sondergaard, Per Solberg Sorensen
Summary: In the open-label extension phase of the trial, treatment with dimethyl fumarate did not show any significant effects on clinical or MRI outcomes, as well as serum concentrations of NFL. A relatively equal number of patients showed evidence of progression and improvement, raising questions for future studies.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Jutta Duenschede, Christoph Ruschil, Benjamin Bender, Annerose Mengel, Tobias Lindig, Ulf Ziemann, Markus C. Kowarik
Summary: The aim of this study was to validate the clinical-radiological match in MS patients with acute relapse. Results showed a clinical-radiological mismatch in 43% of cases. These patients were older at the time of relapse, had a longer disease duration, and had more previous relapses. Further studies are needed to understand the factors contributing to this mismatch.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kornelia Laichinger, Paula Bombach, Jutta Duenschede, Christoph Ruschil, Maria-Ioanna Stefanou, Evelyn Dubois, Sven Poli, Katharina Feil, Ulf Ziemann, Markus Kowarik, Annerose Mengel
Summary: In this study, the prevalence of intrathecal IgG synthesis and B cell activation in AIS patients was determined. It was found that 5.7% of patients had intrathecal IgG synthesis, and one third of these patients had concurrent chronic inflammatory CNS disease. No significant correlation was found with stroke characteristics.
Article
Geriatrics & Gerontology
Dinne Skjaerlund Christensen, Ellen Garde, Hartwig Roman Siebner, Erik Lykke Mortensen
Summary: This study found that there is an association between cognitive decline and perceived stress in midlife, with higher levels of stress leading to greater decline in cognitive ability.
Article
Medicine, General & Internal
Vasileios Siokas, Sara Roesch, Maria-Ioanna Stefanou, Rebecca Buesink, Vera Wilke, Jennifer Sartor-Pfeiffer, Kamaldeen Adeyemi, Sven Poli, Efthimios Dardiotis, Ulf Ziemann, Katharina Feil, Annerose Mengel
Summary: This study investigated the effects of prophylactic melatonin administration on post-stroke delirium after intracerebral hemorrhage. The results showed that melatonin did not have a significant effect in preventing post-ICH PSD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
M. Celicanin, A. P. Harrison, J. Kvistgaard Olsen, L. Korbo, A. Lokkegard, B. Danneskiold-Samsoe, H. R. Siebner, T. V. Ilic, E. M. Bartels
Summary: Acoustic myography (AMG) is a noninvasive method to study muscle activity. In this study, we investigated whether AMG can detect abnormal motor activity in patients with Parkinson's disease (PD) and how it is affected by medication. The results showed that the S:T ratio was lower in PD patients compared to healthy controls during active movement of the biceps and extensor carpi radialis longus muscles. The E score was also lower during active and passive flexion/extension movements in the off-medication state. These findings suggest that the S:T ratio and E score during active elbow flexion and extension could be useful in assessing abnormal motor activity and the effectiveness of drug treatment in PD.
PHYSIOLOGICAL REPORTS
(2023)
Editorial Material
Neurosciences
Lukas Ga, Pedro Caldana Gordon, Ulf Ziemann
Summary: Recently, discrepancies were found in EEG responses in the cerebral cortex elicited by cerebellar TMS. The authors discussed possible reasons for the observed differences and highlighted the significance of reliably measuring cbTMS-evoked EEG responses in testing cerebellum-to-cortex connectivity.
Article
Medicine, General & Internal
Franca Laura Fries, Benedict Kleiser, Patricia Schwarz, Maria P. Tieck, Kornelia Laichinger, Annerose Mengel, Ulf Ziemann, Markus C. Kowarik
Summary: We report a case of a 62-year-old male patient with subacute neurological deterioration, progressive tetraparesis, and cytoalbumin dissociation in the lumbar cerebrospinal fluid (CSF). The patient had a pre-existing cervical spinal stenosis with mild tetraparesis. The intermediate aggravation of tetraparesis was due to pneumonia with septic constellation, and the cytoalbumin dissociation was interpreted as Froin's syndrome (FS) due to spinal stenosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Therese Adrian, Mads Hornum, Filip Krag Knop, Karl Bang Christensen, Thomas Almdal, Peter Rossing, Lisa Lida, Niels Sondergaard Heinrich, Vincent Oltman Boer, Anouk Marsman, Esben Thade Petersen, Hartwig Roman Siebner, Bo Feldt-Rasmussen
Summary: This study aimed to investigate the association between liver fibrosis and chronic kidney disease (CKD) in patients with type 2 diabetes, and to compare different diagnostic methods for liver fibrosis. The results showed that using any of the three methods, significant liver fibrosis was found in 38% of CKD patients and 28% of non-CKD patients. However, after adjustments for age, sex, body mass index, and duration of diabetes, no strong independent association was found between liver fibrosis and established CKD as assessed by FibroScan, FIB-4 score, and NFS, respectively.
Article
Neurosciences
Wala Mahmoud, Morten Haugland, Ander Ramos-Murguialday, Hans Hultborn, Ulf Ziemann
Summary: This study aimed to evaluate the resistance to externally induced wrist extension in chronic stroke patients. Using a hand-held dynamometer, torque, joint movement, and electromyography (EMG) were simultaneously measured to assess the resistance. The results demonstrated the ability to objectively measure the resistance to muscle stretch and distinguish muscle overactivity components from muscle and soft tissue stiffness in chronic stroke patients.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2023)
Article
Neuroimaging
Stefano Cerri, Douglas N. Greve, Andrew Hoopes, Henrik Lundell, Hartwig R. Siebner, Mark Muehlau, Koen Van Leemput
Summary: In this paper, a longitudinal method for whole-brain segmentation of MRI scans is described and validated. The method extends an existing segmentation method to better track subtle morphological changes in neuroanatomical structures and white matter lesions. The proposed method is validated on datasets of control subjects and patients with Alzheimer's disease and multiple sclerosis and compared with other methods. The results show higher test-retest reliability and increased sensitivity to longitudinal disease effect differences.
NEUROIMAGE-CLINICAL
(2023)
Article
Urology & Nephrology
Therese Adrian, Mads Hornum, Filip Krag Knop, Thomas Almdal, Peter Rossing, Lisa Lida, Niels Sondergaard Heinrich, Vincent Oltman Boer, Anouk Marsman, Esben Thade Petersen, Hartwig Roman Siebner, Bo Feldt-Rasmussen
Summary: This study investigated the prevalence of NAFLD in patients with type 2 diabetes and compared the difference between patients with and without CKD. The results showed that the incidence of NAFLD was similar among patients with type 2 diabetes, and there was no significant association with CKD (stages 3-5).
Article
Neurosciences
David Emanuel Vetter, Christoph Zrenner, Paolo Belardinelli, Tuomas Petteri Mutanen, Gabor Kozak, Laura Marzetti, Ulf Ziemann
Summary: This study investigated the relationship between functional connectivity in the motor network and corticospinal excitability using real-time EEG-TMS experiment. The findings suggest that high functional connectivity predicts high corticospinal excitability, but should be considered along with mu-power and stimulus interval.
