期刊
JOURNAL OF GENERAL VIROLOGY
卷 102, 期 4, 页码 -出版社
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.001574
关键词
Green tea; EGCG; SARS-CoV-2; pseudotype; MERS-CoV; SARS-CoV
资金
- German Ministry of Health (BMG) [CHARIS 6b, CHARIS 6a]
- German Centre for Infection Research (DZIF) [TTU 01.802]
EGCG showed antiviral activity against SARS-CoV-2 by blocking virus entry and inhibiting infections, suggesting it could be a lead structure for developing more effective anti-COVID-19 drugs.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has caused a pandemic with tens of millions of cases and more than a million deaths. The infection causes COVID-19, a disease of the respiratory system of divergent severity. No treatment exists. Epigallocatechin-3-gallate (EGCG), the major component of green tea, has several beneficial properties, including antiviral activities. Therefore, we examined whether EGCG has antiviral activity against SARS-CoV-2. EGCG blocked not only the entry of SARS-CoV-2, but also MERS- and SARS-CoV pseudotyped lentiviral vectors and inhibited virus infections in vitro. Mechanistically, inhibition of the SARS-CoV-2 spike-receptor interaction was observed. Thus, EGCG might be suitable for use as a lead structure to develop more effective anti-COVID-19 drugs.
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