Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons

Involvement of NMDA-AKT-mTOR Signaling in Rapid Antidepressant-Like Activity of Chaihu-jia-Longgu-Muli-tang on Olfactory Bulbectomized Mice

(2019) Xing Wang et al.   Frontiers in Pharmacology

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy

(2018) Yu Hong et al.   Drug Design Development and Therapy

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

(2017) Matthew D. McGeough et al.   JOURNAL OF CLINICAL INVESTIGATION

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway

(2016) Ming Ye et al.   BIOMEDICINE & PHARMACOTHERAPY

Pyroptosis

(2016) Lieselotte Vande Walle et al.   CURRENT BIOLOGY

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

(2016) Sheng-Tao Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains

(2016) Nina Dupuis et al.   Journal of Neuroinflammation

Endocytosis of indium-tin-oxide nanoparticles by macrophages provokes pyroptosis requiring NLRP3-ASC-Caspase1 axis that can be prevented by mesenchymal stem cells

(2016) Abderrahim Naji et al.   Scientific Reports

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

(2015) Chen-Chen Tan et al.   Journal of Neuroinflammation

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histopathological evidence that hippocampal atrophy following status epilepticus is a result of neuronal necrosis

(2013) Gogi Kumar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Recognition of Bacteria by Inflammasomes

(2012) Jakob von Moltke et al.   Annual Review of Immunology

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Antidepressant-like effects of the saponins extracted from Chaihu-jia-longgu-muli-tang in a rat unpredictable chronic mild stress model

(2011) Lu-Fan Li et al.   FITOTERAPIA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

SCLM, total saponins extracted fromChaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice

(2010) Yadong Liu et al.   PHARMACEUTICAL BIOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

The role of cytokines in the pathophysiology of epilepsy

(2008) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY