期刊
JOURNAL OF DRUG TARGETING
卷 30, 期 1, 页码 31-45出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1061186X.2021.1920025
关键词
HSP60; cancer diagnostic biomarker; therapeutic target; tumour resistance; exosomal HSP60
资金
- Natural Science Foundation of Liaoning Province [20180550371]
- LiaoNing Revitialization Talents Program [XLYC1908031, XLYC1802007]
- 111 Project of China [D20029]
- Young and middle-aged teachers' career development support plan of Shenyang Pharmaceutical University [ZQN2019012]
- 2019 Natural Science Foundation Guidance Plan Project of Liaoning province [2019-ZD-0447]
- 'Chunhui Plan' Cooperative Project of Education Ministry of Liaoning Province [LN2019016]
HSP60, a molecular chaperone, plays a crucial role in cancer research due to its potential as a diagnostic biomarker and therapeutic target. Its involvement in apoptosis, metastasis, drug resistance, and liquid biopsy make it a promising area of study, although further research is required to fully understand its mechanisms in various types of cancer.
Heat shock proteins (HSPs), most of which are molecular chaperones, are highly conserved proteins produced by cells under physiological stress or pathological conditions. HSP60 (57-69 kDa) can promote or inhibit cell apoptosis through different mechanisms, and its abnormal expression is also related to tumour cell metastasis and drug resistance. In recent years, HSP60 has received increasing attention in the field of cancer research due to its potential as a diagnostic and prognostic biomarker or therapeutic target. However, in different types of cancer, the specific mechanisms of abnormally expressed HSP60 in tumour carcinogenesis and drug resistance are complicated and still require further study. In this article, we comprehensively review the regulative mechanisms of HSP60 on apoptosis, its applications as a cancer diagnostic biomarker and a therapeutic target, evidence of involvement in tumour resistance and the applications of exosomal HSP60 in liquid biopsy. By evaluating the current findings of HSP60 in cancer research, we highlight some core issues that need to be addressed for the use of HSP60 as a diagnostic or prognostic biomarker and therapeutic target in certain types of cancer.
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