Article
Engineering, Biomedical
Qiong Li, Cheng Ma, Yingpeng Ma, Yiping Ma, Yan Mao, Zelan Meng
Summary: The study investigated the effect of gold nanoparticles (GNPs) on bimatoprost loading/uptake and release kinetics from contact lenses. The presence of GNPs significantly improved drug uptake and sustained release of bimatoprost, without affecting the critical properties of the lenses for therapeutic application.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Pharmacology & Pharmacy
Zhihong Liu, Zhengtong Jiao, Rong Luo, Jingsong Fu
Summary: This study investigated the use of PEGylated solid lipid nanoparticles (TP-pSLNs) to improve drug loading capacity of contact lenses and prolong ocular drug delivery for better clinical outcomes in glaucoma treatment. The TP-pSLNs showed improved drug uptake and sustained release compared to traditional methods, with potential applications for improved ocular drug delivery and treatment efficacy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hui Dang, Chunyun Dong, Li Zhang
Summary: In this study, a novel drug-loaded contact lens was developed to increase drug loading capacity and sustain drug delivery. The drug-loaded contact lens showed improved performance and sustained release compared to conventional soaked lens and eye drop solution.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Francesco Sartini, Martina Menchini, Chiara Posarelli, Giamberto Casini, Michele Figus
Summary: This systematic review focuses on in vivo studies of contact lenses as a drug-delivery system in glaucoma therapy, highlighting technical limitations and future perspectives. Nanoparticle-loaded contact lenses and lenses with implants appear to be the most promising drug-delivery systems, although challenges such as initial burst drug release and patient acceptance may hinder their widespread use. Clinical trials are needed to further explore the role of contact lenses in improving glaucoma patient care.
APPLIED SCIENCES-BASEL
(2021)
Article
Pharmacology & Pharmacy
Li Zhang, Chunxia Zhang, Hui Dang
Summary: The novel brimonidine-loaded nanostructured lipid carriers (Br-NLCs)-laden silicone contact lenses can effectively control the release of brimonidine in the eye for the treatment of glaucoma, showing promising clinical outcomes.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dan (Chau Thuy) Nguyen, Joseph Dowling, Richie Ryan, Peter McLoughlin, Laurence Fitzhenry
Summary: In this study, NAR-impregnated hydrogel lenses were manufactured to achieve controlled daily drug release. The lenses showed comparable properties to commercial lenses and were fully characterized for their physical and chemical stability. The controlled drug release of NAR was achieved through diffusion-controlled mechanisms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Zhichang Du, Gangnan Zhao, Anyang Wang, Wei Sun, Shengli Mi
Summary: The paper introduces a microfluidic contact lens that integrates a microchannel and a micropump to achieve drug release through the mechanical action of blinking. Experimental results demonstrate the controllability of liquid release and the good flexibility, light transmittance, and biocompatibility of the microfluidic contact lens. The liquid exchange between the eye and the contact lens provides potential for personalized medicine.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Review
Pharmacology & Pharmacy
Furqan A. Maulvi, Ditixa T. Desai, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: The delivery of drugs to ocular tissues can be challenging, and drug-laden contact lenses are being explored as a possible solution. However, there are several issues that need to be addressed before clinical application and commercialization, such as changes in contact lens properties during manufacture.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity for enhancing the effectiveness of active pharmaceutical ingredients and targeting alternative routes of drug administration. By understanding the binding behavior of polymers on nanoparticle surfaces, it is possible to optimize nanoparticle formulations and guide mucoadhesion.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Jeffrey Watchorn, Samantha Stuart, Aaron J. Clasky, Matthew H. Oliveira, Darcy C. Burns, Frank X. Gu
Summary: Nanoparticle-based drug delivery systems have gained popularity as they improve the effectiveness of pharmaceutical ingredients and enhance absorption through mucosal drug delivery. However, the binding behavior of polymer-coated nanoparticles to mucin proteins can differ from that of polymer in solution, and the nanoparticle core influences the binding fate of polymer materials.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Hongyu Yang, Ming Zhao, Dandan Xing, Jian Zhang, Ting Fang, Faxing Zhang, Zhihao Nie, Yaming Liu, Lihua Yang, Ji Li, Dongkai Wang
Summary: The number of people with eye diseases has increased due to the use of electronics. However, the bioavailability of eye drops remains low. Therefore, the development of contact lenses that can deliver drugs for extended periods without affecting vision has become a focus of research. This article reviews the physical and chemical properties of drug-laden contact lenses, the development and classification of contact lenses, and the characteristics of commonly used materials. It also discusses methods to overcome the problems of high burst and short release duration using drug-laden contact lenses, and predicts the future direction of contact lens research.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Physical
Tina Lovrec-Krstic, Kristjan Orthaber, Uros Maver, Tomislav Sarenac
Summary: The field of ophthalmology is rapidly expanding with the increasing incidence of eye-related diseases. Due to an aging population and climate change, the number of ophthalmic patients will continue to rise, leading to potential under-treatment. Drug-loaded contact lenses provide a promising alternative to eye drops for ocular therapy, potentially transforming clinical practice. This review focuses on current roles, materials, drug binding, and future developments of contact lenses in ocular drug delivery.
Article
Chemistry, Multidisciplinary
Kristen N. Sikora, Laura J. Castellanos-Garcia, Joseph M. Hardie, Yuanchang Liu, Michelle E. Farkas, Vincent M. Rotello, Richard W. Vachet
Summary: A dual-mode mass spectrometry imaging method was used to evaluate the distributions and biochemical effects of anti-TNF-alpha nanoparticle stabilized capsules in mice, revealing that most anticipated biochemical changes occur in sub-organ regions separate from where the nanomaterials accumulate. The study demonstrates the power of matrix-assisted laser desorption/ionization mass spectrometry imaging in evaluating both expected and unexpected outcomes associated with complex therapeutic delivery systems.
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)