期刊
JOURNAL OF DENTAL RESEARCH
卷 100, 期 8, 页码 790-797出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/00220345211000656
关键词
oxidative stress; bacterial virulence; biofilm; cytokine; host pathogen interactions; periodontal disease; periodontitis
资金
- Public Health Service [R-56-DE13664, DE019730, DE022508, DE022724]
- National Institute of Dental and Craniofacial Research
Filifactor alocis is a diagnostic indicator of periodontal disease, known for its resistance to oxidative stress, production of unique proteases and collagenases causing host cell damage, enabling it to thrive and outcompete other pathogens in the inflammatory environment of the periodontal pocket.
Filifactor alocis, a fastidious Gram-positive obligate anaerobic bacterium, is a newly appreciated member of the periodontal community that is now proposed to be a diagnostic indicator of periodontal disease. Its pathogenic characteristics are highlighted by its ability to survive in the oxidative stress-rich environment of the periodontal pocket and to significantly alter the microbial community dynamics by forming biofilms and interacting with several oral bacteria. Here, we describe the current understanding of F. alocis virulence attributes, such as its comparative resistance to oxidative stress, production of unique proteases and collagenases that can cause structural damage to host cells, and dysregulation of the immune system, which enable this bacterium to colonize, survive, and outcompete other traditional pathogens in the inflammatory environment of the periodontal pocket. Furthermore, we explore the recent advancements and future directions for F. alocis research, including the potential mechanisms for oxidative stress resistance and our evolving understanding of the interactions and mechanisms of bacterial survival inside neutrophils. We also discuss the current genetic tools and challenges involved in manipulating the F. alocis genome for the functional characterization of the putative virulence genes. Collectively, this information will expedite F. alocis research and should lead to the identification of prime targets for the development of novel therapeutics to aid in the control and prevention of periodontal disease.
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