期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 106, 期 10, 页码 E4202-E4209出版社
ENDOCRINE SOC
DOI: 10.1210/clinem/dgab258
关键词
F-18-AlF-NOTA-octreotide; F-18-OC PET/CT; tumor-induced osteomalacia; TIO; Ga-68-DOTATATE PET/CT; hypophosphatemia
资金
- National Natural Science Foundation of China [91859207]
This study retrospectively analyzed 17 cases and found that F-18-OC PET/CT scans had a positive impact on the diagnosis of TIO in 14 patients. After surgical removal of the lesions, patients' symptoms improved rapidly, and serum phosphate levels normalized.
Context: Tumor-induced osteomalacia (TIO) is a paraneoplastic disorder, usually caused by benign mesenchymal tumors that produce high levels of fibroblast growth factor 23. The only curative therapy is resection of the causative tumors. Objective: This research was conducted to evaluate the efficacy of F-18-AlF-NOTA-octreotide (F-18-OC) positron emission tomography/computed tomography (PET/CT) in detecting TIO and its impact on patient management. Methods: Retrospective analysis was conducted of 17 patients with hypophosphatemic osteomalacia suspected to be TIO. A F-18-OC PET/CT study was performed in all 17 patients to localize the tumor and Ga-68-DOTATATE PET/CT was performed in 4 out of 17 patients; both studies were performed within 1 week of each other. Both studies were interpreted blindly without the knowledge of other imaging findings. The image findings were compared with the results of histopathological examinations and clinical follow-ups. Results: The F-18-OC PET/CT scans were positive in 14 patients. Furthermore, 4 of 14 patients were scanned with both F-18-OC and Ga-68-DOTATATE PET/CT. Both studies were able to localize the tumor in all 4 patients. In total, 14 patients had surgery to remove the lesions. Postsurgical pathological examination confirmed causative tumors in these patients, whose symptoms diminished promptly. Serum phosphate levels normalized, confirming the diagnosis of TIO. F-18-OC PET/CT sensitivity, specificity, and accuracy were 87.5%, 100%, and 88.2% respectively. F-18-OC PET/CT findings affected patient management in 88.2% of cases. Conclusion: F-18-OC PET/CT scan is useful in the detection of tumors causing TIO. Further studies with larger patient populations are needed to validate the result.
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