Review
Biochemistry & Molecular Biology
Anca Cardoneanu, Luana Andreea Macovei, Alexandra Maria Burlui, Ioana Ruxandra Mihai, Ioana Bratoiu, Ioana Irina Rezus, Patricia Richter, Bogdan-Ionel Tamba, Elena Rezus
Summary: The temporomandibular joint (TMJ) is essential for jaw movement and function. TMJ osteoarthritis (TMJ OA) is caused by various factors and affects all joint structures. Chondrocyte loss, extracellular matrix (ECM) degradation, and subchondral bone remodeling are important in TMJ OA. Therapies such as platelet-rich plasma (PRP), hyaluronic acid (HA), and mesenchymal stem cell-based treatment (MSCs) have shown promise in restoring joint structures in TMJ OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: CTGF is a multifunctional protein that plays different roles in different cells and conditions. CTGF antibodies have the potential to be a new drug for osteoarthritis. Abnormal CTGF expression is associated with inflammation and cartilage degeneration, making CTGF a potential therapeutic target for osteoarthritis treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanhong Song, Ziyi Wu, Ping Zhao
Summary: This article discusses the potential of using metformin in the treatment of osteoarthritis, highlighting its benefits in inhibiting inflammation, modulating autophagy, antagonizing oxidative stress, and reducing pain levels for patients. Metformin, with its anti-inflammatory and anti-aging properties, has the potential to be an effective drug for treating osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Lamuedra, Paula Gratal, Lucia Calatrava, Victor Luis Ruiz-Perez, Adrian Palencia-Campos, Sergio Portal-Nunez, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Summary: Inactivation of Evc partially prevents chondrocyte hypertrophy in osteoarthritis (OA), but does not improve cartilage damage. Chondrocyte hypertrophy itself is not a pathogenic event in the progression of OA.
Article
Rheumatology
Qian Liu, Ruoxin Wang, Shujie Hou, Feng He, Yuanjun Ma, Tao Ye, Shibin Yu, Hongwei Chen, Helin Wang, Mian Zhang
Summary: Abnormal biomechanical loading leads to increased formation of chondrocyte-derived exosomes, which have promoters of calcification and inhibitors decreased, resulting in accelerated abnormal cartilage calcification in TMJ OA. Inhibition of degenerative chondrocyte-derived exosomes is expected to be a new way to prevent and treat TMJ OA.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Endocrinology & Metabolism
Feng He, Yuanjun Ma, Shi Li, Haozhe Ren, Qian Liu, Xiaohua Chen, Hui Miao, Tao Ye, Qian Lu, Zuge Yang, Tianle Li, Xin Tong, Hongxu Yang, Mian Zhang, Helin Wang, Yazhou Wang, Shibin Yu
Summary: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease, and the role of necroptosis and downstream key DAMPs in TMJOA has been explored in this study. The research findings suggest that necroptosis contributes to cartilage degeneration and synovitis in TMJOA, and targeting the necroptotic vicious cycle may provide a potential therapeutic strategy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Orthopedics
Ke Lu, Feng Ma, Dan Yi, Huan Yu, Liping Tong, Di Chen
Summary: Temporomandibular joint (TMJ) osteoarthritis (OA) is a TMJ disorder characterized by pain, movement limitation, cartilage degeneration, and joint dysfunction. This review article summarizes recent findings on signaling pathways involved in TMJ OA development and progression, highlighting the importance of understanding these pathways for potential therapeutic strategies. Multiple signaling pathways, including Wnt/beta-catenin, TGF-beta and BMP, Indian Hedgehog, FGF, NF-kappa B, and Notch pathways, are implicated in the pathological process of TMJ OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Cell & Tissue Engineering
H. Wang, Y. Shi, F. He, T. Ye, S. Yu, H. Miao, Q. Liu, M. Zhang
Summary: Abnormal adipogenesis and decreased expression of GDF11 were observed in degenerative cartilage of TMJ OA. Supplementation of GDF11 effectively inhibits adipogenesis of chondrocytes and alleviates TMJ condylar cartilage degeneration. GDF11 may inhibit abnormal adipogenesis of chondrocytes by affecting the SUMOylation of PPAR gamma.
BONE & JOINT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Chenyang Zhuang, Zixiang Wang, Weisin Chen, Hanquan Wang, Bo Tian, Hong Lin
Summary: The study demonstrates that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage through the NF-κB signaling pathway, indicating its potential therapeutic value for treating OA. In vivo evaluation shows that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in ACLT mouse models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Xinyan Li, Yuanyuan Han, Guimiao Li, Yingze Zhang, Juan Wang, Chen Feng
Summary: This review summarizes the role of Wnt signaling pathways in joint development and cartilage maintenance, with a focus on aberrant mechanical loading and inflammation as major contributors to osteoarthritis progression. Additionally, emerging Wnt-related modulators and treatments targeting Wnt signaling are discussed, providing valuable insights for diagnosing and treating osteoarthritis and other degenerative joint diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Moon-Chang Choi, Jiwon Jo, Myeongjin Lee, Jonggwan Park, Yoonkyung Park
Summary: The study found that the antimicrobial peptide Cramp induces chondrocyte catabolism via the NF-kappa B signaling pathway, accelerating the progression of OA and leading to cartilage degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Li Liu, Yaping Feng, Shiyu Hu, Huimin Li, Yanyan Li, Jin Ke, Xing Long
Summary: The study revealed that PDCD4 is highly expressed in cartilage from MIA-induced TMJOA rats, inhibiting autophagy and promoting apoptosis. Furthermore, Akt mediates PDCD4-induced apoptosis and inhibited autophagy.
Article
Orthopedics
Tristan Maerz, Michael D. Newton, Mackenzie Fleischer, Samantha E. Hartner, Karissa Gawronski, Lucas Junginger, Kevin C. Baker
Summary: The study found acute catabolic bone remodeling following ACL rupture, with thinning of subchondral bone in the medial femoral condyle and gains in the lateral femoral condyle. NIR imaging demonstrated immediate and sustained reduction of bone anabolism, with a significant increase in bone catabolism at 14 days.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Cell Biology
Yi Fan, Chen Cui, Peiran Li, Ruiye Bi, Ping Lyu, Yanxi Li, Songsong Zhu
Summary: Research has identified a novel stem cell niche in condylar cartilage, containing fibrocartilage stem cells (FCSCs) that play a crucial role in the development and regeneration of fibrocartilage. Understanding the properties of FCSCs may inform the development of promising biological strategies for the treatment of TMD in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Bingqiang Hua, Jin Qiu, Xiaoping Ye, Yiwen Kuang, Xianwen Liu
Summary: This study reveals the significant role of epigenetic PPAR gamma dysregulation in the pathogenesis of TMJOA. The suppression of PPAR gamma can be alleviated by DNA demethylation intervention, leading to cartilage restoration and stabilizing cartilage homeostasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jian Wang, Wanju Sun, Allen Bond, Chengpin Xu, Kai Li, Donglin Ren, Xin Song, Fang Tan, Kun Jiao, Ming Ni, Jun Zhang, Yunpeng Bai, Mingfei Wang
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Article
Genetics & Heredity
Xuguang Nie, Jinxuan Zheng, Christopher L. Ricupero, Ling He, Kai Jiao, Jeremy J. Mao
Review
Cardiac & Cardiovascular Systems
Qianchuang Sun, Shuyan Liu, Kexiang Liu, Kai Jiao
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Medicine, Research & Experimental
Yinghui Zhang, Jia Guo, Yongchao Li, Kai Jiao, Yingbo Zhang
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Multidisciplinary Sciences
Q. Song, K. Jiao, L. Tonggu, L. G. Wang, S. L. Zhang, Y. D. Yang, L. Zhang, J. H. Bian, D. X. Hao, C. Y. Wang, Y. X. Ma, D. D. Arola, L. Breschi, J. H. Chen, F. R. Tay, L. N. Niu
Review
Chemistry, Multidisciplinary
Wen Qin, Chen-yu Wang, Yu-xuan Ma, Min-juan Shen, Jing Li, Kai Jiao, Franklin R. Tay, Li-na Niu
ADVANCED MATERIALS
(2020)
Article
Biology
Jian-fei Yan, Wen-pin Qin, Bo-cheng Xiao, Qian-qian Wan, Franklin R. Tay, Li-na Niu, Kai Jiao
BIOLOGICAL REVIEWS
(2020)
Article
Engineering, Biomedical
Jing Li, Jian-Fei Yan, Qian-Qian Wan, Min-Juan Shen, Yu-Xuan Ma, Jun-Ting Gu, Peng Gao, Xiao-Yi Tang, Fan Yu, Ji-Hua Chen, Franklin R. Tay, Kai Jiao, Li-Na Niu
Summary: This study developed a self-mineralization strategy by covalently conjugating polyacrylic acid on Bio-Gide? membranes, enhancing mineralization and promoting bone regeneration. Experimental results showed that HBG underwent progressive mineralization in vivo, increased stiffness, and stimulated osteogenic differentiation of MSCs to expedite in-situ bone regeneration.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Multidisciplinary
Qian-Qian Wan, Wen-Pin Qin, Yu-Xuan Ma, Min-Juan Shen, Jing Li, Zi-Bin Zhang, Ji-Hua Chen, Franklin R. Tay, Li-Na Niu, Kai Jiao
Summary: This review comprehensively analyzes the possible crosstalk between bone and intrabony peripheral nerves, highlighting the role of peripheral nerves in bone development and repair through signals such as neurotransmitters, neuropeptides, and neurotrophins. In return, bone supports nerves mechanically and offers a protective environment. This crosstalk is not limited to physiological conditions, but also plays a role in various bone diseases, providing potential avenues for tissue engineering and disease treatment.
Article
Nanoscience & Nanotechnology
Bingqing Zhang, Qiang Li, Qinglin Xu, Baochao Li, Heng Dong, Yongbin Mou
Summary: Inflammatory bowel disease (IBD) is closely related to oxidative stress. Developing a novel method to scavenge reactive oxygen species (ROS) and alleviate colon inflammation is a promising strategy. CeO2@PP possesses excellent antioxidant and anti-inflammatory properties for scavenging ROS and modulating macrophage polarization, which is beneficial for efficient colitis therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Cell Biology
Jing Zhen, Kailin Jiao, Keke Yang, Maoxuan Wu, Qian Zhou, Bingmo Yang, Wei Xiao, Chunyan Hu, Ming Zhou, Zhong Li
Summary: Endothelial-mesenchymal transition (EndMT) is a process that promotes tumor progression and metastasis, with 27-Hydroxycholesterol (27-HC) playing a role in promoting breast cancer cell invasion and migration through EndMT. The 14-3-3 eta/GSK-3 beta/beta-catenin complex is involved in this pathway, indicating a potential target for inhibiting EndMT and breast cancer cell migration.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liping Xue, Cheng Xiong, Juanjuan Li, Yuling Ren, Liwei Zhang, Kangwei Jiao, Chen Chen, Peng Ding
BIOSCIENCE REPORTS
(2020)
Article
Oncology
Kailin Jiao, Jing Zhen, Maoxuan Wu, Mengying Teng, Keke Yang, Qian Zhou, Chunyan Hu, Ming Zhou, Yuan Li, Zhong Li
CANCER BIOLOGY & MEDICINE
(2020)