An SNX10-dependent mechanism downregulates fusion between mature osteoclasts

Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice

(2020) Merle Stein et al.   BONE

Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo

(2019) Lee Roth et al.   Science Signaling

FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts

(2019) Ricardo A. Battaglino et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

How cells fuse

(2019) Nicolas G. Brukman et al.   JOURNAL OF CELL BIOLOGY

Genetics of Osteopetrosis

(2018) Eleonora Palagano et al.   Current Osteoporosis Reports

SNX10 Plays a Critical Role in MMP9 Secretion via JNK-p38-ERK Signaling Pathway

(2017) Chun Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A BaSiC tool for background and shading correction of optical microscopy images

(2017) Tingying Peng et al.   Nature Communications

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

(2017) Eva-Lena Stattin et al.   Scientific Reports

DC-STAMP: A Key Regulator in Osteoclast Differentiation

(2016) Ya-Hui Chiu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myoblast fusion: Experimental systems and cellular mechanisms

(2016) Eyal D. Schejter   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion

(2016) Ksenia Smurova et al.   Cell Reports

Targeting the C-type Lectins-Mediated Host-Pathogen Interactions with Dextran

(2016) Sergey Pustylnikov et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Osteoclast fusion is initiated by a small subset of RANKL-stimulated monocyte progenitors, which can fuse to RANKL-unstimulated progenitors

(2015) Noam Levaot et al.   BONE

The elementary fusion modalities of osteoclasts

(2015) Kent Søe et al.   BONE

Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

(2015) Liang Ye et al.   PLoS Genetics

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology

(2015) Hanna Witwicka et al.   PLoS One

Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts

(2014) Nah-Young Shin et al.   JOURNAL OF CELL BIOLOGY

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

SNX10mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity

(2012) Alessandra Pangrazio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

AnSNX10mutation causes malignant osteopetrosis of infancy

(2012) Memet Aker et al.   JOURNAL OF MEDICAL GENETICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

(2011) Rohan D. Teasdale et al.   BIOCHEMICAL JOURNAL

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

Osteopetrosis with micro-lacunar resorption because of defective integrin organization

(2009) Harry C Blair et al.   LABORATORY INVESTIGATION

SNX–BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting

(2009) Jan R.T. van Weering et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular mediators of macrophage fusion

(2009) Laura Helming et al.   TRENDS IN CELL BIOLOGY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Mechanisms of membrane fusion: disparate players and common principles

(2008) Sascha Martens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanics of membrane fusion

(2008) Leonid V Chernomordik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetics, pathogenesis and complications of osteopetrosis

(2007) Andrea Del Fattore et al.   BONE