Article
Oncology
Xiangyu Zhao, Yuxing Chen, Xiaoqin Sun, Zaoke He, Tao Wu, Chenxu Wu, Jing Chen, Jinyu Wang, Kaixuan Diao, Xue-Song Liu
Summary: This study found that EFNA4, a member of the EPH family, is amplified and up-regulated in lung tumor patients, especially in those with lymph node metastases. Overexpression of EFNA4 promotes lung tumor cell proliferation and migration, while knockdown or knockout of EFNA4 inhibits cell proliferation and migration. These findings suggest that the amplification of the EFNA4 gene may play an oncogenic role in promoting lung cancer lymph node metastasis.
Article
Surgery
Zheng-Yun Zhang, Jiao Guan, Xin-Ping Wang, Di-Si Hao, Zun-Qiang Zhou
Summary: This study evaluated the clinical significance of positive lymph nodes in patients with ampullary adenocarcinoma. The results showed that lymph nodes #13, #17, #12, and #8 were commonly involved, and the number of positive nodes in these regions had a significant impact on the patients' survival rates.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Takao Shigenobu, Yusuke Takahashi, Yohei Masugi, Ryutaro Hanawa, Hirokazu Matsushita, Atsushi Tajima, Hiroaki Kuroda
Summary: Histologic subtyping offers some prognostic value in lung adenocarcinoma. A significant correlation was found between micropapillary dominance and higher risk of brain metastasis in patients with resected lung adenocarcinoma. These findings may be important for postoperative management considerations.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Leilei Shen, Juntang Guo, Weidong Zhang, Chaoyang Liang, Han Chen, Yang Liu
Summary: The necessity of performing 4L lymph node dissection (LND) remains uncertain and controversial. This study aimed to analyze the clinicopathological and survival outcomes of 4L LND from the perspective of histology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Sho Wakasu, Tetsuzo Tagawa, Naoki Haratake, Fumihiko Kinoshita, Yuka Oku, Yuki Ono, Tomoyoshi Takenaka, Yoshinao Oda, Mototsugu Shimokawa, Masaki Mori
Summary: This study found that mature tertiary lymphoid structures (TLSs) were associated with a lower frequency of lymph node metastasis and favorable outcomes. Mature TLSs may support antitumor immunity by activating lymphocytes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Feng Li, Suokai Zhai, Li Fu, Lin Yang, Yousheng Mao
Summary: This study aimed to develop nomograms for intraoperative prediction of lymph node metastasis in early-stage lung adenocarcinoma. The nomograms showed good discriminatory performance in predicting lymph node metastasis and N2 lymph node metastasis. Additionally, it was found that there were survival outcome differences between systematic mediastinal lymphadenectomy and limited mediastinal lymphadenectomy for high-risk patients.
Article
Cell Biology
Bo Dong, Chunli Wu, Lan Huang, Yu Qi
Summary: This study identified the potential role of macrophages in lymph node metastasis, and the macrophage-related gene SPP1 as a potential biomarker for early lymph node metastasis in LUAD. The study also revealed the involvement of a long non-coding RNA (lncRNA, AC037441) in regulating early lymph node metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Keiju Aokage, Kenji Suzuki, Masashi Wakabayashi, Tomonori Mizutani, Aritoshi Hattori, Haruhiko Fukuda, Shun-Ichi Watanabe
Summary: The study aimed to develop a prediction model of pathological lymph node status (PLNS) in peripheral adenocarcinoma with a dominant solid component, based on clinical and radiological factors. The model showed high diagnostic performance in predicting PLNS, successfully identifying patients who could benefit from wedge resection or other local therapies.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Oncology
Wenhao Zhang, Guang Mu, Jingjing Huang, Chengyu Bian, Hongchang Wang, Yan Gu, Yang Xia, Liang Chen, Mei Yuan, Jun Wang
Summary: This study aimed to investigate the occurrence of lymph node metastasis in T1 lung adenocarcinoma and analyze the relationship with clinical variables. The results showed that patients with T1 lung adenocarcinoma located deep within the lung tissue, with solid components, invasive preoperative imaging features, and larger diameters have a higher risk of lymph node metastasis. The micropapillary pathological subtype represents a significant high-risk factor for N2 skip lymph node metastasis.
Article
Cell Biology
Xin Ji, Zihao Wang, Guige Wang, Lijun Tang, Zhijun Han
Summary: Lymph node metastasis (LNM) is a common pathway in lung adenocarcinoma (LUAD) and is associated with a poor prognosis and higher recurrence risk. Discovering drivers and targets of LNM is crucial for early detection of high-risk patients and guiding personalized therapy.
Article
Oncology
Hideki Endoh, Ryohei Yamamoto, Akihiro Ichikawa, Satoshi Shiozawa, Nobuhiro Nishizawa, Yukitoshi Satoh, Noboru Oriuchi
Summary: The evaluation of lymph node metastasis on preoperative 2-[F-18] fluoro-D-deoxyglucose (FDG)-positron emission tomography for lung cancer is still uncertain. False-positive lymph nodes were associated with older age, bilateral hilar FDG uptake, and no swollen nodes. Metastatic lymph nodes show higher FDG uptake than false-positive lymph nodes, and older patient age, bilateral hilar FDG uptake, and no swollen nodes are associated with no metastases.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Donglai Chen, Qifeng Ding, Wei Wang, Xiaofan Wang, Xuejie Wu, Yiming Mao, Chang Chen, Yongbing Chen, Yongsheng Zhang
Summary: Extracapsular lymph node involvement (ECLNI) is a strong predictor of unfavorable overall survival (OS) and recurrence-free survival (RFS) for lung adenocarcinoma (LUAD) patients. Factors such as tumor spread through air spaces are associated with ECLNI presence. ECLNI status provides additional precision in stratifying pN1 and pN2 patients with significantly different RFS and OS outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Charles A. Gusho, Michael P. Fice, Cristina M. O'Donoghue, Steven Gitelis, Alan T. Blank
Summary: Soft tissue sarcomas (STS) are mesenchymal tumors that may rarely metastasize to lymph nodes. This retrospective study found that 3.7% of extremity STS had regional lymph node metastasis (RLNM), with higher rates in specific subtypes. Independent prognostic factors for disease-specific survival included age, tumor grade, tumor size, and RLNM.
JOURNAL OF SURGICAL RESEARCH
(2021)