Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach

Structure-Based Identification of Potential Drugs Against FmtA of Staphylococcus aureus: Virtual Screening, Molecular Dynamics, MM-GBSA, and QM/MM

(2021) Vikram Dalal et al.   PROTEIN JOURNAL

Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death

(2021) Bailey Balouch et al.   PLoS One

Structure-based mimicking of hydroxylated biphenyl congeners (OHPCBs) for human transthyretin, an important enzyme of thyroid hormone system

(2021) Reena Kumari et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Cln1 ‐mutations suppress Rab7‐RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis

(2020) Chinmoy Sarkar et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Acidic Compartment Size, Positioning, and Function during Myogenesis and Their Modulation by the Wnt/Beta-Catenin Pathway

(2020) Kayo M. Bagri et al.   Biomed Research International

PPT1 Inhibition enhances the anti-tumor activity of anti-PD-1 antibody in melanoma

(2020) Gaurav Sharma et al.   JCI Insight

N-glycosylation of High Mobility Group Box 1 protein (HMGB1) modulates the interaction with glycyrrhizin: A molecular modeling study

(2020) Gérard Vergoten et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

N-glycosylation and ubiquitinylation of PD-L1 do not restrict interaction with BMS-202: A molecular modeling study

(2020) Christian Bailly et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Computational guided identification of novel potent inhibitors of N-terminal domain of nucleocapsid protein of severe acute respiratory syndrome coronavirus 2

(2020) Poonam Dhankhar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

(2019) Tamar Sapir et al.   Frontiers in Cellular Neuroscience

Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins

(2018) Qun Zhou   CURRENT DRUG TARGETS

Batten disease: biochemical and molecular characterization revealing novel PPT1 and TPP1 gene mutations in Indian patients

(2018) Jayesh Sheth et al.   BMC Neurology

Effect of geraniol against arecoline induced toxicity in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9

(2018) Barkha Shakya et al.   TOXICOLOGY MECHANISMS AND METHODS

PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

(2018) Vito W Rebecca et al.   Cancer Discovery

A Novel Therapeutic Strategy for Pancreatic Cancer: Targeting Cell Surface Glycan Using rBC2LC-N Lectin–Drug Conjugate (LDC)

(2017) Osamu Shimomura et al.   MOLECULAR CANCER THERAPEUTICS

A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles

(2017) Vito W. Rebecca et al.   Cancer Discovery

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

(2015) Malia B Potts et al.   Nature Chemical Biology

Neuroprotection and lifespan extension in Ppt1 −/− mice by NtBuHA: therapeutic implications for INCL

(2013) Chinmoy Sarkar et al.   NATURE NEUROSCIENCE

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoyl protein thioesterase 1 modulates tumor necrosis factor α-induced apoptosis

(2009) Claudine Tardy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH