期刊
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
卷 32, 期 12, 页码 1564-1583出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2021.1926893
关键词
Aqueous two-phase system; chitin; drug carrier; injectable hydrogels; microspheres
资金
- National Key R&D program of China [2018YFB1105502]
- National Natural Science Foundation of China [21875168, 21674083]
In this study, carboxymethyl chitin microspheres (CMCH-Ms) were successfully prepared and embedded in thermosensitive hydroxypropyl chitin (HPCH) hydrogels without the use of organic solvents, surfactants, or crosslinking agents. The CMCH-Ms/HPCH gel scaffolds exhibited biodegradable and non-cytotoxic properties, with sustained drug release and no burst release observed. This composite hydrogel shows great potential for controlled local drug delivery systems.
Microspheres and injectable hydrogels derived from natural biopolymers have been extensively investigated as controlled local drug delivery systems. In this study, we prepared carboxymethyl chitin microspheres (CMCH-Ms) with a diameter of 10-100 mu m through physical crosslinking by increasing temperature in an aqueous two-phase system without using organic solvents, surfactants and crosslinking agents. The stable microspheres keeping spherical shape with porous microstructure in different pH environments were embeded in thermosensitive hydroxypropyl chitin (HPCH) hydrogels. The morphology, gelation rate, swelling, rheological and mechanical properties, in vitro degradation and cytotoxicity, drug loading and drug release of the CMCH-Ms/HPCH gel scaffolds were examined. In vitro degradation and cytotoxicity test indicated that CMCH-Ms/HPCH gel scaffolds were biodegradable and non-cytotoxic. Moreover, no organic solvent was used in the preparation and drug loading process of CMCH-Ms/HPCH gel scaffold. Importantly, less burst drug release and long-term sustained-release from the CMCH-Ms/HPCH composite hydrogel was observed than those from only CMCH-Ms or HPCH hydrogel. Thus, the composite CMCH-Ms/HPCH hydrogel exhibited great potential application for loading different drugs and sustained drug release in controlled local drug delivery systems.
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