期刊
BRAIN RESEARCH
卷 1624, 期 -, 页码 95-102出版社
ELSEVIER
DOI: 10.1016/j.brainres.2015.07.022
关键词
miR-29c; Alzheimer's disease; NAV3 protein; microRNAs; APPswe/PS Delta E9 mice
The microRNA-29 family (miRNA-29s) has three mature members, miR-29a, miR-29b and miR-29c, which have been implicated in the regulation of the pathogenesis of Alzheimer's disease (AD). The miR-29 family members exhibit differential regulation in various diseases and different subcellular distribution. In the present study, we initially investigated differential expression of miR-29c in the hippocampus and the frontal cortex of the young APPswe/PS Delta E9 mouse brain, accompanied by inverse expression of neurone navigator 3 (NAV3), a regulator of axon guidance. We observed that miR-29c directly mediated downregulation of NAV3 protein expression in vitro. The mouse NAV3 mRNA has a functional miR-29c binding site in the 3' UTR, which localized in the position between 830-836 bp of 3'UTR region, slightly different from human NAV3 mRNA binding site. These observations suggest that miR-29c may be involved in neurodegenerative processes by regulating NAV3 expression in the young AD mouse. (C) 2015 Elsevier B.V. All rights reserved.
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