Article
Radiology, Nuclear Medicine & Medical Imaging
Qiao-Yuan Lu, Zhen Guan, Xiao-Yan Zhang, Xiao-Ting Li, Rui-Jia Sun, Qing-Yang Li, Ying-Shi Sun
Summary: Contrast-enhanced MRI has been found to provide accurate differentiation of ypT0-1 from ypT2-4 tumors after neoadjuvant chemotherapy and radiation therapy. The diagnostic performance of contrast-enhanced MRI is better than that of T2-weighted imaging and DWI. yT stage on contrast-enhanced MRI is an independent predictor of ypT0-1 tumors.
Article
Medical Laboratory Technology
Yaqi Wang, Xiaojun Fan, Hua Bao, Fan Xia, Juefeng Wan, Lijun Shen, Yan Wang, Hui Zhang, Yulin Wei, Xue Wu, Yang Shao, Xinxiang Li, Ye Xu, Sanjun Cai, Zhen Zhang
Summary: The combination of 5'-end motif profile with mrTRG has the potential to predict the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients.
CLINICAL CHEMISTRY
(2023)
Article
Oncology
Patricia A. Ganz, Ron D. Hays, Karen L. Spritzer, Andre Rogatko, Clifford Y. Ko, Linda H. Colangelo, Amit Arora, Judith O. Hopkins, Terry L. Evans, Greg Yothers
Summary: This article explores the health-related quality of life (HRQOL) outcomes in rectal cancer patients receiving neoadjuvant chemoradiotherapy. The study finds that there were no significant differences in HRQOL by treatment arm, but HRQOL worsened after neoadjuvant chemoradiotherapy. Host factors played a significant role in post-treatment HRQOL.
Article
Oncology
Caroline Bascoul-Mollevi, Sophie Gourgou, Christophe Borg, Pierre-Luc Etienne, Emmanuel Rio, Eric Rullier, Beata Juzyna, Florence Castan, Thierry Conroy
Summary: Results from the PRODIGE 23 study showed that neoadjuvant chemotherapy (NAC) with mFOLFIRINOX and preoperative chemoradiotherapy improved disease-free survival in patients with locally advanced rectal cancer. This study aimed to assess the impact of this treatment on health-related quality of life (HRQOL) outcomes.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Siyu Zhang, Bin Tang, Mingrong Yu, Lei He, Ping Zheng, Chuanjun Yan, Jie Li, Qian Peng
Summary: This study investigated whether radiomics features based on prenCRT magnetic resonance imaging nodes could predict treatment response in preoperative locally advanced rectal cancer (LARC) lymph nodes. The prediction model based on radiomics signature and selected LN morphologic characteristics showed good performance in assessing treatment response.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Medicine, General & Internal
Weerapat Suwanthanma, Saowanee Kitudomrat, Chakrapan Euanorasetr
Summary: The study investigated the clinical and pathological outcomes of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation followed by curative surgery, identifying tumor length and lymph node involvement as potential predictive factors for pathological complete response. Patients achieving pCR showed higher 5-year disease-free and overall survival rates compared to non-pCR patients.
Article
Oncology
J. F. Huisman, I. J. H. Schoenaker, R. M. Brohet, O. Reerink, H. van der Sluis, F. C. P. Moll, E. de Boer, J. C. de Graaf, W. H. de Vos tot Nederveen Cappel, G. L. Beets, H. L. van Westreenen
Summary: The study demonstrates that the introduction of structured multidisciplinary response evaluation leads to a significant decrease in patients with locally advanced rectal cancer achieving complete response after nCRT, reducing the need for surgery and improving stoma-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Joanna Socha, Krzysztof Bujko
Summary: Total neoadjuvant therapy (TNT) refers to delivering both (chemo)radiation and chemotherapy before surgery to reduce distant metastases, but without improvement in overall survival and with severe toxicity. A systematic review of randomized trials comparing TNT with neoadjuvant (chemo)radiation showed that follow-up was too short to determine long-term overall survival. One trial indicated worse neurotoxicity-related quality of life and higher rate of toxicity with TNT, despite a reduction in distant metastases incidence. The absence of overall survival benefit could be due to the ATRESS phenomenon.
Article
Oncology
Christina Liu Cui, William Yu Luo, Bard Clifford Cosman, Samuel Eisenstein, Daniel Simpson, Sonia Ramamoorthy, James Murphy, Nicole Lopez
Summary: Watch and wait (WW) is a cost-effective strategy for patients with stage II/III rectal cancer compared to abdominoperineal resection (APR) and low anterior resection (LAR), with WW dominating both surgical options at a willingness to pay threshold of $100,000. The model was most sensitive to rates of distant recurrence and regrowth after WW, and probabilistic sensitivity analysis showed WW to be the dominant strategy across a range of thresholds.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toru Tochigi, Sophia C. Kamran, Anushri Parakh, Yoshifumi Noda, Balaji Ganeshan, Lawrence S. Blaszkowsky, David P. Ryan, Jill N. Allen, David L. Berger, Jennifer Y. Wo, Theodore S. Hong, Avinash Kambadakone
Summary: This study assessed the use of CT-based fractal dimension and texture analysis in predicting the therapeutic response to nCRT in patients with locally advanced rectal cancer. The research found that fractal dimension was a significant parameter for predicting the efficacy of nCRT.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Oliver J. Ott, Cihan Gani, Lars H. Lindner, Manfred Schmidt, Ulf Lamprecht, Sultan Abdel-Rahman, Axel Hinke, Thomas Weissmann, Arndt Hartmann, Rolf D. Issels, Daniel Zips, Claus Belka, Robert Grutzmann, Rainer Fietkau
Summary: The HyRec trial evaluated an intensified neoadjuvant and multimodality treatment schedule for locally recurrent rectal cancer patients, showing promising efficacy and high feasibility, with comparable toxicities and very high pathologically confirmed complete remission rates.
Article
Oncology
Gemma G. Kenter, Stefano Greggi, Ignace Vergote, Dionyssios Katsaros, Juliusz Kobierski, Heleen van Doorn, Fabio Landoni, Jacobus van der Velden, Nicholas Reed, Corneel Coens, Iske van Luijk, Nicoletta Colombo, Elzbietta van der Steen-Banasik, Nelleke Ottevanger, Antonio Casado
Summary: This trial compared the efficacy of neoadjuvant chemotherapy followed by surgery with concomitant chemoradiation in patients with stage Ib2-IIB cervical cancer. The results showed no significant difference in the 5-year overall survival rate between the two treatment arms.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park
Summary: This study analyzed the predictive factors, recurrence patterns, oncologic outcomes, and prognostic factors of patients with pathologic complete response (pCR) in rectal cancer who underwent radical surgery after neoadjuvant chemoradiotherapy (nCRT). The study found that clinical node negativity, tumor size < 4 cm, and well differentiation were significant independent clinical predictors for achieving pCR. Patients with pCR had better long-term outcomes compared to those without pCR.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Huajing Teng, Yan Wang, Xin Sui, Jiawen Fan, Shuai Li, Xiao Lei, Chen Shi, Wei Sun, Maxiaowei Song, Hongzhi Wang, Dezuo Dong, Jianhao Geng, Yangzi Zhang, Xianggao Zhu, Yong Cai, Yongheng Li, Bo Li, Qingjie Min, Weihu Wang, Qimin Zhan
Summary: Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying the heterogeneous patient response. In this study, the researchers conducted 16S rRNA sequencing on fecal specimens from LARC patients and discovered a decrease in microbial diversity after nCRT. They also found that Bacteroides vulgatus-mediated nucleotide biosynthesis is associated with nCRT resistance, and nonrespon-sive tumors have upregulated genes related to DNA repair and nucleoside trans-port. Additionally, the researchers identified uric acid as a potential prognosis marker for LARC patients receiving nCRT.
Article
Oncology
Delphine Dayde, Jillian Gunther, Yutaka Hirayama, David C. Weksberg, Adam Boutin, Gargy Parhy, Clemente Aguilar-Bonavides, Hong Wang, Hiroyuki Katayama, Yuichi Abe, Kim-Anh Do, Kazuo Hara, Takashi Kinoshita, Koji Komori, Yasuhiro Shimizu, Masahiro Tajika, Yasumasa Niwa, Y. Alan Wang, Ronald DePinho, Samir Hanash, Sunil Krishnan, Ayumu Taguchi
Summary: The study demonstrates that blood-based biomarkers such as VEGFR3, EGFR, and COX2 can predict the response of locally advanced rectal cancer patients to neoadjuvant chemoradiation. Combining these biomarkers significantly improves the predictive performance.
Article
Health Care Sciences & Services
Sabe Sabesan, Marie Malica, Chantal Gebbie, Clare Scott, David Thomas, John Zalcberg
Summary: This paper describes the steps and processes involved in the development and implementation of the Australasian Teletrial Model (ATM) by the Clinical Oncology Society of Australia. The implementation of ATM has improved access to clinical trials for patients in regional and rural areas, and enhanced collaboration between metropolitan and regional sites.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Gastroenterology & Hepatology
Charlotte S. S. Johnstone, Cherry E. E. Koh, Gregory J. J. Britton, Michael J. J. Solomon, Andrew J. J. McLachlan
Summary: This study investigated the implementation and outcomes of a pain-management regimen for patients undergoing pelvic exenteration surgery. The use of opioid-sparing regional techniques and preperitoneal catheters has increased since the implementation of a novel peri-operative pain-treatment algorithm. The dose of opioids required at the time of discharge has significantly reduced.
COLORECTAL DISEASE
(2023)
Review
Gastroenterology & Hepatology
Charlotte S. H. Johnstone, Daniel Roberts, Stephanie Mathieson, Daniel Steffens, Cherry E. E. Koh, Michael J. J. Solomon, Andrew J. J. McLachlan
Summary: This systematic review aimed to study the impact of pelvic exenteration surgery on the survival rate of patients with advanced colorectal cancer. The study found that postoperative pain was common, and the presence of preoperative pain predicted adverse pain outcomes in the postoperative period, with more extensive resections being associated with a higher likelihood of pain.
COLORECTAL DISEASE
(2023)
Article
Oncology
Saissan Rajendran, Chu Luan Nguyen, Kilian G. M. Brown, Michael J. Solomon
Summary: Pelvic exenteration surgery has become the standard of care for advanced pelvic malignancy. The use of complex vascular resection and reconstructive techniques in this field is considered cutting-edge. This article summarizes the historical evolution of oncovascular surgery in the pelvis and highlights its potential for future treatment advancements.
Article
Oncology
Catalina A. Palma, Charlotte S. van Kessel, Michael J. Solomon, Scott Leslie, Nicola Jeffery, Peter J. Lee, Kirk K. S. Austin
Summary: This study compared the treatment outcomes and post-operative complications between partial cystectomy (PC) and radical cystectomy (RC) in patients with locally advanced or recurrent rectal cancer. It found that PC had good oncological outcome in patients with locally advanced rectal cancer, while RC was more suited for recurrent rectal cancer.
Article
Surgery
Daniel Steffens, Michael J. Solomon, Peter Lee, Kirk Austin, Cherry Koh, Christopher Byrne, Sascha Karunaratne, Sophie Hatcher, Kiera Taylor, Kate McBride
Summary: This study summarizes the surgical, survival, and quality of life outcomes of pelvic exenteration surgeries in a single referral hospital over 28 years. The results show excellent overall outcomes but significant differences depending on the tumor type.
ANZ JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Narcyz Ghinea, Wendy Lipworth, Ian Kerridge, John R. Zalcberg
Summary: Novel medicines are rapidly entering the market and being used alone or in combination to treat various illnesses. This article provides a primer to help practitioners understand the changing therapeutic landscape and its impact on evidence generation, access to interventions, patient experience, and quality of care.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Surgery
Hugh L. Giddings, Kheng-Seong Ng, Michael J. Solomon, Daniel Steffens, Joe Van Buskirk, Jane Young
Summary: This study aims to investigate the trends in total abdominal colectomy (TAC) rates for ulcerative colitis (UC) in New South Wales (NSW). The study found that the rate of TACs has decreased over the past two decades, which may have been influenced by the introduction of biologics. However, in the biologic era, there were higher rates of complications and ICU admissions, suggesting poorer patient physiological status at the time of surgery.
ANZ JOURNAL OF SURGERY
(2023)
Article
Surgery
Hugh L. L. Giddings, Kheng-Seong Ng, Michael J. J. Solomon, Daniel Steffens, Joe Van Buskirk, Jane Young
Summary: This study aimed to evaluate outcomes of ileal pouch-anal anastomosis (IPAA) surgery in New South Wales (NSW) and found that the results were comparable to global standards. Concentrating IPAA surgery in specialized hospitals may ensure equity of access and promote research and training collaboration.
ANZ JOURNAL OF SURGERY
(2023)
Article
Surgery
Kilian G. M. Brown, Michael J. Solomon, Alexander Heriot, Frank Frizelle
ANZ JOURNAL OF SURGERY
(2023)
Review
Surgery
Kilian G. M. Brown, Kheng-Seong Ng, Michael J. Solomon, Pierre H. Chapuis, Cherry E. Koh, Nima Ahmadi, Kirk K. S. Austin
Summary: Complete mesocolic excision is a surgical technique used for colon cancer treatment, involving precise dissection of the avascular embryonic plane. However, the impact of this approach on overall and disease-free survival remains unclear, and there are concerns about the associated risks of extensive central vascular dissection. Due to the current uncertainty, different national guidelines have varied recommendations on whether complete mesocolic excision should be performed.
ANZ JOURNAL OF SURGERY
(2023)
Article
Nursing
Shantelle Smith, Daniel Sapkaroski, Margaret Brand, Anh Tran, John Zalcberg, Robert G. Stirling
Summary: This retrospective cohort study analyzed the clinical care pathways of Stage III-IV non-small cell lung cancer patients in Victoria based on the Optimal Care Pathway recommendations. The study found unwarranted variations in the implementation of supportive care and palliative care, with higher utilization of palliative care at the time of treatment rather than early after diagnosis. The findings highlight the importance of multidisciplinary meetings and early supportive care screening in improving communication and integration of palliative care into routine clinical practice.
NURSING & HEALTH SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Henry E. Badgery, Tjuntu Muhlen-Schulte, John R. Zalcberg, Bianka D'souza, Jan F. Gerstenmaier, Craig Pickett, Jaswinder Samra, Daniel Croagh
Summary: In this multicentre observational study, a high degree of interobserver variability was found among clinicians and radiologists in assessing resectability of pancreatic cancer, with higher agreement among radiologists. This highlights the importance of central review and quality control initiatives to ensure consistent clinical decision making for patients with PDAC.
Article
Surgery
Deena P. Harji, Niamh McKigney, Cherry Koh, Michael J. Solomon, Ben Griffiths, Martyn Evans, Alexander Heriot, Peter M. Sagar, Galina Velikova, Julia M. Brown
Summary: The aim of this study was to understand the short-term health-related quality-of-life (HrQoL) differences between patients undergoing surgical and palliative treatments for locally recurrent rectal cancer (LRRC). The study found that patients undergoing curative surgery had better overall HrQoL and a higher burden of pelvic symptoms.
Article
Surgery
Shaveen Kanakaratne, Jonathan Hong, Michael J. Solomon, Christopher J. Young
Summary: This study aimed to investigate the functional and quality of life outcomes of patients who underwent RP and IPAA surgery. The results showed that patients at our institution had excellent functional outcomes and quality of life, which were comparable to larger institutions.
ANZ JOURNAL OF SURGERY
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)