Article
Chemistry, Multidisciplinary
Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Ali Bakhshi, Azam Rasti, Fateme Haghiralsadat, Seyed Morteza Naghib, Davood Tofighi
Summary: This research assessed the feasibility of a novel AS1411-CS-AuNPs delivery system for carrying MTX into breast cancer cells. The results showed that the system could penetrate the cancer cells, release the therapeutic drug, and had no significant cytotoxicity on non-target cells.
NANOTECHNOLOGY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Weihe Yao, Chenyu Liu, Ning Wang, Hengjun Zhou, Hailiang Chen, Weihong Qiao
Summary: Targeted multi-responsive drug delivery systems with MRI capabilities were successfully synthesized, showing high stability and biocompatibility in vivo with excellent drug targeting effects.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Engineering, Multidisciplinary
Xu Xue, Han Liu, Sicheng Wang, Yan Hu, Biaotong Huang, Mengmeng Li, Jie Gao, Xiuhui Wang, Jiacan Su
Summary: This study presents a new type of nanoparticle for treating osteoarthritis, which achieves targeted delivery and anti-inflammatory treatment through cell membrane modification and photothermal responsive drug release. It exhibits significant therapeutic efficacy for osteoarthritis in vivo.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Hongying Chen, Jiang Deng, Xintong Yao, Yungang He, Hanyue Li, Zhixiang Jian, Yi Tang, Xiaoqing Zhang, Jingqing Zhang, Hongwei Dai
Summary: A dual targeting nano-biomimetic drug delivery vehicle was designed for efficient treatment of malignancies in jaw bones, showing excellent bone and cancer targeting abilities. The nanoparticles were camouflaged with a hybrid membrane of head and neck squamous cell carcinoma WSU-HN6 cells and red blood cells, modified with oligopeptides of aspartate acid, which resulted in enhanced uptake and effective cancer growth inhibition properties.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Andrade, Maria J. Ramalho, Silvio B. Santos, Luis D. R. Melo, Rita S. Santos, Nuno Guimaraes, Nuno F. Azevedo, Joana A. Loureiro, Maria C. Pereira
Summary: Antimicrobial resistance (AMR) poses a significant threat to global health, with Methicillin-resistant Staphylococcus aureus (MRSA) being a major concern. Nanoparticles (NPs) have emerged as a promising approach for treating MRSA infections, acting as antibacterial agents or drug delivery systems. The targeted delivery of NPs to the infection site is crucial for effective treatment, allowing for high concentrations of therapeutics while minimizing toxicity to healthy cells and reducing AMR emergence and disruption of the healthy microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Moonkyoung Jeong, Yuna Jung, Junyong Yoon, Jinyoung Kang, Seo Hyeon Lee, Woojin Back, Hyoyeon Kim, Michael J. Sailor, Dokyoung Kim, Ji-Ho Park
Summary: A porous silicon-based nanomedicine is developed to deliver an antirheumatic drug to inflamed synovium and degrade into bone-remodeling products. The nanomedicine shows immunomo-dulatory and antiresorptive effects, and effectively ameliorates the progression of rheumatoid arthritis in a mouse model.
Article
Chemistry, Multidisciplinary
Aditya Girish, Ketan Jolly, Nijmeh Alsaadi, Maria de la Fuente, Arielle Recchione, Ran An, Dante Disharoon, Zachary Secunda, Shruti Raghunathan, Norman F. Luc, Cian Desai, Elizabeth Knauss, Xu Han, Keren Hu, Hanyang Wang, Ujjal Didar Singh Sekhon, Nathan Rohner, Umut A. Gurkan, Marvin Nieman, Matthew D. Neal, Anirban Sen Gupta
Summary: This study presents the design and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles (t-TLNPs) that can specifically localize at an injury site and release thrombin for hemostatic action. The nanoparticles were found to restore hemostatic dysfunction and reduce bleeding in both in vitro and in vivo experiments.
Article
Pharmacology & Pharmacy
Fatemeh Farjadian, Zahra Faghih, Maryam Fakhimi, Pooya Iranpour, Soliman Mohammadi-Samani, Mohammad Doroudian
Summary: This study presents the synthesis of glucosamine-modified mesoporous silica-coated magnetic nanoparticles (MNPs) for the delivery of the anticancer drug methotrexate. The prepared structure showed controlled release and targeted delivery of methotrexate in vitro and demonstrated significant anticancer potential and MRI contrast enhancement in an in vivo breast cancer model.
Article
Engineering, Biomedical
Yu Xia, Guoyi Tang, Yi Chen, Changbing Wang, Min Guo, Tiantian Xu, Mingqi Zhao, Yongjian Zhou
Summary: RNA interference (RNAi) is a promising method for treating malignant tumors, and in this study, RGDfC-SeNPs were successfully synthesized as a tumor-targeted carrier for delivering siSox2 to HepG2 liver cancer cells. The results showed that RGDfC-Se@siSox2 effectively silenced Sox2, inhibited tumor cell proliferation, migration, and invasion, induced apoptosis through reactive oxygen species production and mitochondrial membrane potential disruption, and significantly inhibited tumor growth in mice bearing HepG2 tumors. These findings suggest that RGDfC-SeNPs could be a valuable gene carrier for specific gene-targeted therapy in HCC.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Na-Hyun Lee, Sumin You, Ali Taghizadeh, Mohsen Taghizadeh, Hye Sung Kim
Summary: The cell membrane cloaking technique, which utilizes natural design cues, is a promising bioinspired nanotechnology for surface modification of nanoparticles. This technique can replicate complex physicochemical properties and biomimetic functions, thereby enhancing nanotherapeutic platforms. However, there are challenges to be addressed for clinical translation and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Taranom Mobasheri, Elham Rayzan, Mahsima Shabani, Mina Hosseini, Ghanbar Mahmoodi Chalbatani, Nima Rezaei
Summary: Research focuses on developing new therapeutic strategies for neuroblastoma, targeting different genes and utilizing nano-drug delivery systems to improve treatment efficacy. The combination of specific drug targets and nano-drug delivery systems may lead to lower systemic side effects and improved therapeutic effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Lingzhi Zhang, Mingyan Li, Guiqiu Zhang, Changxing Gao, Shengfang Wang, Tingting Zhang, Chen Ma, Lianyan Wang, Qing Zhu
Summary: Berberine (BBR) is being explored for oral treatment of various disorders, especially those involving inflammation, and nanotechnology-based drug delivery systems are considered effective for enhancing the oral absorption of BBR. The hybrid delivery system MNEHDS is designed to optimize the immunoregulatory effects of BBR in the gastrointestinal tract, showing promising therapeutic efficacy in murine colitis models.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Ya-Nan Li, Xiaoju Shi, Dandan Sun, Shulan Han, Yifang Zou, Lingzhi Wang, Leilei Yang, Yutong Li, Ying Shi, Jianfeng Guo, Caitriona M. O'Driscoll
Summary: In this study, the potential of melarsoprol (MEL) for hepatocellular carcinoma (HCC) therapy was investigated for the first time using in vitro and in vivo experimental approaches. A folate-targeted polyethylene glycol-modified amphiphilic cyclodextrin nanoparticle was developed for safe, efficient and specific delivery of MEL. The targeted nanoformulation achieved cell-specific uptake, cytotoxicity, apoptosis and migration inhibition in HCC cells, and significantly prolonged the survival of mice with orthotopic tumor without causing toxicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Jin-Shuai Lan, Yan-Hong Qin, Li Liu, Rui-Feng Zeng, Yang Yang, Kai Wang, Yue Ding, Tong Zhang, Rodney J. Y. Ho
Summary: The study focused on novel self-assembled UA-MTX NPs targeting the folate receptor for synergistic anticancer activity. Results showed significant improvement in water solubility, pH-responsive drug release, excellent folate receptor targeting, and enhanced antitumor efficacy in vitro and in vivo. These findings suggest that UA-MTX NPs targeting folate receptors are an efficient strategy for combination chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Xiaoqing Li, Vamsidhara Vemireddy, Qi Cai, Hejian Xiong, Peiyuan Kang, Xiuying Li, Monica Giannotta, Heather N. Hayenga, Edward Pan, Shashank R. Sirsi, Celine Mateo, David Kleinfeld, Chris Greene, Matthew Campbell, Elisabetta Dejana, Robert Bachoo, Zhenpeng Qin
Summary: The study successfully synthesized gold nanoparticles for increasing blood-brain barrier permeability, demonstrating that transcranial picosecond laser stimulation can regulate BBB permeability, enabling drug delivery without disrupting the structure of the neurovascular unit.
Article
Food Science & Technology
Samaneh Rashtbari, Gholamreza Dehghan, Leila Sadeghi, Leila Sareminia, Milad Iranshahy, Mehrdad Iranshahi, Alireza Khataee, Yeojoon Yoon
Summary: This study investigated the interaction between natural phenolic antioxidants and bovine serum albumin (BSA), revealing a high affinity between them. ELA exhibited a higher affinity for BSA compared to ULA and ULB, possibly due to the presence of hydroxyl groups in its structure. Furthermore, the formation of complexes resulted in an enhancement of BSA's antioxidant activity, which was attributed to their structural differences.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Reza Yekta, Leila Sadeghi, Gholamreza Dehghan
Summary: Despite its regulatory role in microtubule stability, Tau protein also plays an important role in protecting and stabilizing DNA molecules. This study shows that the glycation of lysine residues in the microtubule-binding domain of Tau protein reduces its affinity for DNA, due to structural modifications. Under hyperglycemic conditions, the localization of Tau protein on pericentromeric heterochromatin decreases. These findings suggest that the structural stability of Tau protein and the presence of glycated lysine residues affect its ability to bind to DNA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Leila Khalili, Gholamreza Dehghan, Nader Sheibani, Alireza Khataee
Summary: The production of multifunctional lipid-polymer hybrid nanoparticles offers great opportunities for selective and efficient therapeutics delivery by combining the biomimetic behavior of liposomes and the advantages of polymers. Bio-modifications show immense potential in addressing the challenges of scaling up production and enhancing biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mina Adampourezare, Mohammad Hasanzadeh, Gholamreza Dehghan, Mohammad-Ali Hosseinpourefeizi, Farzad Seidi
Summary: In this study, a novel optical genosensor was developed for the detection of DNA methylation. The genosensor showed high capability to distinguish methylated DNA from unmethylated DNA, and demonstrated high sensitivity and accuracy.
JOURNAL OF MOLECULAR RECOGNITION
(2022)
Review
Cell Biology
Yong-Seok Song, Andrew J. Annalora, Craig B. Marcus, Colin R. Jefcoate, Christine M. Sorenson, Nader Sheibani
Summary: Cytochrome P450 1B1 plays an important role in maintaining retinal iron homeostasis. By modulating iron levels, it influences oxidative stress and the development of ocular diseases.
Article
Cell Biology
Ismail S. Zaitoun, Yong-Seok Song, Hammam B. Zaitoun, Christine M. Sorenson, Nader Sheibani
Summary: This study established methods for visualizing choroidal macrophages, mast cells, and vasculature in the eyes of albino and pigmented mice, and found similarities between mice and humans in the arterial circle around the optic nerve. Different structural patterns of choriocapillaris were also observed. The findings contribute to the understanding and potential therapeutic targeting of ocular diseases affecting the choroid.
Article
Biochemistry & Molecular Biology
Christine M. Sorenson, Yong-Seok Song, Shoujian Wang, Soesiawati R. Darjatmoko, Mohammad Ali Saghiri, Mahsa Ranji, Nader Sheibani
Summary: Branching morphogenesis is a crucial developmental process that plays a significant role in organogenesis. This study investigates the impact of Bim, a protein involved in apoptosis, on the branching of ureteric bud and retinal vasculature. The findings demonstrate that appropriate expression of Bim is essential for proper apoptosis and branching in both the kidney and eye. Lack of Bim expression leads to increased branching but also results in branching defects and other undesirable consequences.
Article
Biochemistry & Molecular Biology
Yong-Seok Song, Ismail S. Zaitoun, Shoujian Wang, Soesiawati R. Darjatmoko, Christine M. Sorenson, Nader Sheibani
Summary: CYP1B1 expression in the retina is crucial for maintaining cellular redox homeostasis. Its metabolism of 17β-estradiol affects iron metabolism and lipid peroxidation, leading to iron accumulation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yong-Seok Song, Nasim Jamali, Christine M. M. Sorenson, Nader Sheibani
Summary: The integrity of retinal endothelial cell (EC) is crucial for maintaining retinal blood barrier and proper vision. Vitamin D, mainly mediated through the vitamin D receptor (VDR), plays a protective role in EC function. However, little is known about the impact of vitamin D-VDR on retinal EC function and ocular angiogenesis and inflammation. In this study, using retinal EC from VDR-deficient mice, the authors found that VDR expression is essential for endothelial cell-cell and cell-matrix interactions, as well as proliferation, migration, and inflammatory response of retinal EC. Furthermore, VDR deficiency leads to down-regulation of endothelial nitric oxide synthetase, enhanced hepcidin expression, and increased intracellular iron levels, contributing to the altered angiogenic and inflammatory state of retinal EC.
Article
Biotechnology & Applied Microbiology
Davoud Malekzadeh, Asadollah Asadi, Arash Abdolmaleki, Gholamreza Dehghan
Summary: This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.
Article
Environmental Sciences
Nesa Hamidian, Gholamreza Dehghan, Samaneh Rashtbari, Alireza Khataee, Mehdi Khoobi, Nader Sheibani
Summary: A magnetite/Gd3+/beta-cyclodextrin nanoplatform was prepared and used for the degradation of tetracycline. The nanoplatform showed higher peroxidase-mimic activity than natural enzymes. It was able to degrade tetracycline efficiently and could be reused.
Article
Genetics & Heredity
Elham Kamalkazemi, Gholamreza Dehghan, Fereydoon Abedi-Gaballu, Esmaeil Babaei, Behzad Baradaran
Summary: This study aimed to enhance apoptosis in colorectal cancer cells by encapsulating Umbelliprenin (Umb) in nanostructured lipid carriers (NLCs). The results demonstrated that Umb-loaded NLCs had favorable particle size, encapsulation efficiency, and release pattern, and showed significantly increased cytotoxicity and apoptosis in tumor cells by upregulating P53 and Bax and downregulating survivin and Bcl-2.
Review
Behavioral Sciences
Seyed Saman Nemati, Leila Sadeghi, Gholamreza Dehghan, Nader Sheibani
Summary: The hippocampus, located in the brain's medial temporal lobe, plays a crucial role in collecting and transferring information for memory consolidation and spatial orientation. It is implicated in cognitive disorders such as epilepsy and Alzheimer's disease. Research on the hippocampus has been motivated by its asymmetry in healthy individuals and its disruption in neurological diseases. This article reviews the structure and importance of the hippocampus in related diseases, and discusses the asymmetry observed in the brain, particularly in the hippocampus, during the growth and maturation of healthy individuals, as well as the changes observed in patients at molecular, functional, and physiological levels.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Subramanian Dharmarajan, Casandra Carrillo, Zhonghua Qi, Jonathan M. Wilson, Anthony J. Baucum II, Christine M. Sorenson, Nader Sheibani, Teri L. Belecky-Adams
Summary: This study aimed to investigate the impact of chronic inflammation on the loss of pericytes in early diabetic retinopathy. The results showed that both type 1 and type 2 diabetes led to similar progression of retinal pericyte loss and gliosis. However, the expression of inflammatory factors differed between the two diabetes models, with peak expression occurring at different ages. Additionally, retinal vascular changes were more severe in the type 2 diabetes model. Chronic exposure of retinal pericytes to IFN gamma resulted in decreased PDGFR beta signaling and increased levels of active PKC delta and CC3, indicating increased pericyte apoptosis.
Article
Biochemistry & Molecular Biology
Michele C. Larsen, Catherine M. Rondelli, Ahmed Almeldin, Yong-Seok Song, Alhaji N'Jai, David L. Alexander, E. Camilla Forsberg, Nader Sheibani, Colin R. Jefcoate
Summary: This study reveals the regulation of bone marrow cells by polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products through the aryl hydrocarbon receptor (AhR). The absence of Cyp1b1 and activation of AhR by PAH result in similar gene stimulations in these cells. Specific sources of Cyp1b1 are found to be linked to AhR and an OLFR network to modulate BM inflammation through diverse microbiome products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)