Article
Environmental Sciences
Jie Xie, Fankun Zhou, Lu Ouyang, Qi Li, Shaoqi Rao, Rui Su, Shuo Yang, Jiajun Li, Xin Wan, Lingyu Yan, Peishan Liu, Hui Cheng, Lingling Li, Guihua Du, Chang Feng, Guangqin Fan
Summary: This study reveals the metabolic and protein changes associated with neurological damage caused by exposure to a mixture of lead, cadmium, and mercury through metabolomic and proteomic analyses. It suggests that dysregulation of ferroptosis and kynurenine pathways is associated with chronic exposure to a heavy metal mixture-induced neurological impairments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Guanghui Xu, Xiaolong Lin, Yong Yu
Summary: Heavy metals in soil ecosystems pose a potential threat to soil biota. Micro-and nano-plastics (MNPs) can impact the accumulation of heavy metals in plants by altering soil microbial community and causing injury to plants. This study investigated the effects and mechanisms of MNPs on the uptake of Cu, Zn, Pb, and Cd in lettuce. The results showed that MNPs increased the uptake of heavy metals in lettuce by altering the relative abundance of key metal-activation bacteria in rhizospheric soil. The concentrations of heavy metals in nanoparticle treatments were significantly higher than that of microparticle treatments, particularly at higher nanoparticle concentration. Biomarkers and gene expression showed that high concentrations of nanoparticles caused more severe injuries to lettuce plants. Metabolomic analysis revealed that nanoparticles disturbed the metabolism of ATP-binding cassette transporter and plant hormone signal transduction in lettuce roots, leading to increased uptake of heavy metals by lettuce.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Aurang Zeb, Weitao Liu, Nouman Ali, Ruiying Shi, Yuhang Lian, Qi Wang, Jianling Wang, Jiantao Li, Zeqi Zheng, Jinzheng Liu, Miao Yu, Jianv Liu
Summary: This study investigated the effects of tire wear particles (TWPs) on the growth and metabolism of mung bean plants and soil. Despite the accumulation of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in TWPs-treated soils, there was no significant impact on plant growth, indicating a degree of tolerance. However, TWPs exposure had significant effects on soil enzyme activities, plant metabolite profiles, and microbiota.
ENVIRONMENTAL POLLUTION
(2024)
Article
Engineering, Environmental
Hillol Chakdar, Shobit Thapa, Amit Srivastava, Pratyoosh Shukla
Summary: Cyanobacteria have emerged as a potential option for bioremediation of heavy metals due to their unique adaptations and robust metabolic machineries. Understanding their physiological responses and regulation at the molecular level is necessary to identify candidate genes and proteins for improving bioremediation efficiency. These approaches might pave new possibilities of implementing genetic engineering strategies in the future.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Environmental Sciences
Renu Yadav, Gagandeep Singh, Anita Rani Santal, Nater Pal Singh
Summary: Soil and water pollution, rapid industrialization, contaminated irrigation-water, increased waste-production and surge in agricultural land leads to the accumulation of Heavy Metals (HM) with time. HM contamination has raised concern over the past years and new remediation strategies are required to deal with it. Phytoremediation is of great significance in the removal, decomposition and detoxification of hazardous metals from HM-contaminated sites. There is a need for further research and biotechnological efforts to enhance the effectiveness of phytoremediation.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Rishav Garg, Rajni Garg, Md Amir Khan, Manjeet Bansal, Vinod Kumar Garg
Summary: This study successfully removes five heavy metal ions from simulated water using a biosynthesized silica-supported iron oxide nanocomposite. The nanocomposite exhibits excellent adsorption performance and can be utilized as an effective nano-adsorbent for the removal of heavy metal ions from water and wastewater.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gennaro Lettieri, Carmela Marinaro, Rosaria Notariale, Pasquale Perrone, Martina Lombardi, Alessio Trotta, Jacopo Troisi, Marina Piscopo
Summary: Metabolomics is a method to provide an overview of the physiological and cellular state of an organism or tissue. It is particularly useful for studying the influence of the environment on bio-indicator organisms like Mytilus galloprovincialis. However, there is a lack of data on the metabolic baseline of mussel tissues, and the effect of mussel exposure to heavy metals on spermatozoa is unknown, despite the sensitivity of the reproductive system to environmental pollutants.
Article
Engineering, Environmental
Samy Selim, Mahmoud M. Y. Madany, Ahmed Mohamed Reyad, Bassam F. Alowaiesh, Nashwa Hagagy, Mohammad M. Al-Sanea, Salam S. Alsharari, Hamada AbdElgawad
Summary: Tungsten nanoparticles can negatively impact plant growth, but this can be mitigated by plant growth-promoting bacteria. Soil contaminated with WPNS led to the accumulation of W in tested species, while actinobacteria isolated from Saudi Arabia showed potential for reducing the toxic effects of WNPs. Additionally, legume plants activated osmolytes metabolism in response to heavy metal stress, with key enzyme elevation further induced by Saccharomonospora and WNPs co-application.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Microbiology
Karolina A. Biello, Alfonso Olaya-Abril, Purificacion Cabello, Gema Rodriguez-Caballero, Lara P. Saez, Conrado Moreno-Vivian, Victor Manuel Luque-Almagro, Maria Dolores Roldan
Summary: Proteomic, transcriptional, and bioinformatic approaches were used to characterize the molecular response of Pseudomonas pseudoalcaligenes CECT 5344 to cyanide and mercury, highlighting the mechanisms involved in the simultaneous detoxification of both compounds. The results generated could be applied for developing bioremediation strategies for cocontaminated wastes in the mining industry.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Analytical
Evan A. Larson, Trevor T. Forsman, Lachlan Stuart, Theodore Alexandrov, Young Jin Lee
Summary: In this study, a pipeline for rigorous annotation of on-tissue derivatized MSI data using Metaspace was presented and validated. The pipeline enabled fast and accurate annotations of metabolites, and a method to remove false derivatized annotations was developed. This pipeline facilitates broadly targeted spatial metabolomics using multiple derivatization reagents.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Nabaz Omer Hamabor, Ahmed Ibrahim Khwakaram, Mohammed Abdulrazzaq Fattah
Summary: Nowadays, high concentrations of contaminants are a global concern for water quality. This study focuses on the issue in Iraq and proposes a novel technique to improve the quality of wastewater for irrigation. The results show significant differences in various parameters (turbidity, TSS, EC, pH, TN, TP, Ca, Na, CI, SO4) after treating wastewater with sedimentation, dilution, and biochar filter.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Environmental Sciences
Ziyi Niu, Yutian Liu, Yaxi Wang, Ying Liu, Lihong Chai, Hongyuan Wang
Summary: This study found that exposure to lead and copper alters the hepatic bile acid profile, resulting in increased hydrophobicity and toxicity of the bile acid pool. The expression of genes involved in bile acid metabolism and their downstream signaling pathways in the liver were significantly altered by lead and copper exposure. These changes may induce oxidative stress and inflammation, ultimately leading to hepatocyte injury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Jiayi He, ChenChen Liu, Mengzhe Du, Xiyi Zhou, Zhangli Hu, Anping Lei, Jiangxin Wang
Summary: The study investigated the metabolic response of Euglena to environmental stresses and the effects of different toxic chemicals on the content of its products. Through comprehensive metabolomics research, potential regulatory mechanisms and mechanisms behind the differential accumulation of metabolites were discovered.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Yan Lv, Qun-De Zhang, Li-Ming Chang, Duo-Li Yang, Luqman Riaz, Cheng Li, Xiao-Hong Chen, Jian-Ping Jiang, Wei Zhu
Summary: Water pollution from lead poses significant threats to aquatic ecosystems and animals. This study investigated the effects of Pb(NO3)2 on tadpoles and water quality, and found that it impaired tadpole fitness and caused changes in metabolites and gut microbiota. The presence of anions, such as NO3-, influenced the outcomes. Gut microbiota plays an important role in mediating the effects of toxins on aquatic ecosystems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Sajid Hamid Akash, Azka Yaqoob, Kanwal Rehman, Muhammad Imran, Mohammed A. A. Assiri, Fatema Al-Rashed, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: Heavy metals are highly toxic compounds found in the earth's crust. Their environmental levels are consistently rising above permissible limits, causing disruption of metabolism and altered gene or protein expression. Metabolomics, a state-of-the-art analytical tool, is used to investigate the mechanisms of metabolic impairment caused by heavy metal toxicities. It plays a key role in identifying perturbations in lipid and amino acid metabolism and oxidative stress in metabolic impairment. The applications of metabolomics in meeting emerging needs are discussed.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Neurosciences
Marta Nowacka-Chmielewska, Daniela Liskiewicz, Arkadiusz Liskiewicz, Lukasz Marczak, Anna Wojakowska, Jaroslaw Jerzy Barski, Andrzej Malecki
Summary: The combination of the western diet and chronic stress exposure may lead to impairments of neuronal function and signaling, resulting in obesity and metabolic diseases.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Arkadiusz D. Liskiewicz, Lukasz Marczak, Katarzyna Bogus, Daniela Liskiewicz, Marta Przybyla, Joanna Lewin-Kowalik
Summary: Obesity cardiomyopathy increases the risk of heart failure and death, but obesity can be cured. Through global proteomic techniques, the proteomic landscape of obesity cardiomyopathy is characterized to assess whether the cardiac phenotype is still affected after weight loss.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemical Research Methods
Joanna Tracz, Luiza Handschuh, Maciej Lalowski, Lukasz Marczak, Katarzyna Kostka-Jeziorny, Bartlomiej Perek, Maria Wanic-Kossowska, Alina Podkowinska, Andrzej Tykarski, Dorota Formanowicz, Magdalena Luczak
Summary: The study utilized a proteomic approach to analyze leukocyte proteins in different CVD and CKD patients, revealing dysregulation of proteins in leukocyte diapedesis process in advanced CKD. Upregulation of apoptosis-related proteins in CKD was also observed compared to CVD. The increased rate of apoptosis was functionally confirmed at the cellular level through various validation methods.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Oncology
Carmela Ciardullo, Katarzyna Szoltysek, Peixun Zhou, Monika Pietrowska, Lukasz Marczak, Elaine Willmore, Amir Enshaei, Anna Walaszczyk, Jia Yee Ho, Vikki Rand, Scott Marshall, Andrew G. Hall, Christine J. Harrison, Meera Soundararajan, Jeyanthy Eswaran
Summary: This study investigates the clinical significance of B-cell regulators BACH2 and BCL6 in chronic lymphocytic leukaemia (CLL). The results show that low levels of BACH2 and BCL6 RNA expression are associated with shorter overall survival in CLL patients.
Article
Oncology
Urszula Strybel, Lukasz Marczak, Marcin Zeman, Krzysztof Polanski, Lukasz Mielanczyk, Olesya Klymenko, Anna Samelak-Czajka, Paulina Jackowiak, Mateusz Smolarz, Mykola Chekan, Ewa Zembala-Nozynska, Piotr Widlak, Monika Pietrowska, Anna Wojakowska
Summary: Exosomes can serve as biomarkers for predicting and monitoring the response of rectal cancer patients to neoadjuvant radiotherapy. The molecular components of exosomes are associated with the response of patients to radiotherapy and have the highest capacity to discriminate samples of patients with different responses.
Article
Engineering, Environmental
Jakub Zdarta, Katarzyna Jankowska, Urszula Strybel, Lukasz Marczak, Luong N. Nguyen, Piotr Oleskowicz-Popiel, Teofil Jesionowski
Summary: The presence of micropollutants in water, wastewater and soil is a global problem with persistent effects on ecosystems and human health, especially when it comes to the degradation of pharmaceuticals such as estrogens. This study proposes the use of electrospun material for the immobilization of laccase, an oxidoreductase, to degrade estrogens. The immobilized enzyme showed higher resistance to inhibitory agents and improved thermal and storage stability compared to its native form. The degradation of estrogens resulted in a significant reduction in total organic carbon and the formation of low-toxic final products.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Maria Marta Nowacka-Chmielewska, Daniela Liskiewicz, Arkadiusz Liskiewicz, Marta Przybyla, Lukasz Marczak, Anna Wojakowska, Konstancja Grabowska, Mateusz Grabowski, Jaroslaw Jerzy Barski, Andrzej Malecki
Summary: This study used a global brain proteome approach to investigate protein alterations after exposure to a Western diet and/or stress. The results showed that consuming a Western diet led to obesity and changes in serum metabolic parameters. Chronic stress had a significant impact on protein alterations, with 86.3% of detected proteins being down-regulated. However, feeding with a specific diet modified the effects of stress on the brain proteome.
Article
Environmental Sciences
Miroslaw Szwed, Rafal Kozlowski
Summary: The research demonstrates that rock mining activities near Lagow have contaminated the snow cover, leading to significant changes in its chemical and physical properties. Analysis shows that pH, electric conductivity, major ions, and heavy metal levels in the cover increased over time, posing a potential hazard to the local residents.
Article
Biochemistry & Molecular Biology
Jakub Idkowiak, Grazyna Kubiak-Tomaszewska, Paulina Gatarek, Laukasz Marczak, Joanna Kaluzna-Czaplinska, Wieslaw Tarnowski, Mariusz Uryszek, Barbara Bobrowska-Korczak
Summary: Lesniowski-Crohn's disease is a chronic inflammatory bowel disease that requires surgical intervention to improve quality of life and relieve symptoms. This study found changes in blood metabolome three days after ileo-colic resection, indicating a high energy demand during the post-operative period. These results might contribute to the discussion on perioperative nutrition.
Article
Biochemistry & Molecular Biology
Jan J. Rybczynski, Lukasz Marczak, Maciej Stobiecki, Aleksander Strugala, Anna Mikula
Summary: This study aimed to analyze the metabolic profile of post-culture medium as an indication of cell suspension metabolic activity of Cyathea delgadii Sternb. The molecular profile of the tree fern's cell culture was described for the first time. LC-MS and GC-MS analysis identified various compounds in the post-culture medium, including flavonoid derivatives and other primary and secondary metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Dawid Perlikowski, Aleksandra Skirycz, Lukasz Marczak, Katarzyna Lechowicz, Adam Augustyniak, Aenna Michaelis, Arkadiusz Kosmala
Summary: The process of plant recovery after drought cessation is complex and not well understood. The crown tissue, located between shoots and roots, plays a crucial role in this process by facilitating the exchange of metabolites and compounds between these plant organs. In this study, we investigated the metabolomic and lipidomic profiles of crown tissue in drought-tolerant and drought-sensitive genotypes of forage grasses. Our results revealed distinct remodeling patterns of primary metabolome and lipidome between the two genotypes under drought and recovery conditions.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Szuba, Ewa Marzena Kalemba, Mikolaj Krzysztof Wawrzyniak, Jan Suszka, Pawel Chmielarz
Summary: Pedunculate oak is an economically important forest-forming species in Poland, but its seeds are sensitive to desiccation. Due to the scarcity of good-quality seeds caused by the tree's irregular seed production, a new protocol for longer acorn storage at lower temperatures is needed. Storage at -7 degrees C for six months resulted in a significant decrease in seed germination potential, which was accompanied by an increase in certain metabolites.
Article
Energy & Fuels
Miroslaw Szwed, Witold Zukowski, Krzysztof Misztal, Rafal Kozlowski
Summary: This paper presents the results of a study conducted within a cement plant in Ozarow, southeastern Poland, which found that the energy stored in fossil fuels is released through combustion and is a fundamental process in cement production. However, this combustion leads to the emission of greenhouse gases and dust. The chemical composition of Scots pine needles was determined using scanning electron microscopy and energy dispersive spectroscopy, revealing the presence of anthropogenic particles.
Article
Neurosciences
Piotr Piasecki, Kalina Wiatr, Milosz Ruszkowski, Lukasz Marczak, Yvon Trottier, Maciej Figiel
Summary: The toxic interaction between mutant ataxin-3 and subunits of large complexes, as well as the circular molecular structure of these complexes, may play a role in the formation of aggregates and fibrils in SCA3/MJD. These protein complexes are involved in the transport of mitochondria in axons, which leads to altered motility of mitochondria along SCA3 Ki150 neurites.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)