Article
Endocrinology & Metabolism
Annie M. Dude, Nevert Badreldin, Amanda Schieler, Lynn M. Yee
Summary: This retrospective cohort study examined the relationship between periconception glycemic control and congenital anomalies in women with pregestational diabetes. Results showed that higher periconception HbA1c, especially above 9.5%, was significantly associated with major congenital fetal anomalies. The study sample was diverse, including women with type 2 diabetes and from various racial and ethnic backgrounds.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Endocrinology & Metabolism
Cristina Bianchi, Alex Brocchi, Walter Baronti, Francesca Nicoli, Fabrizia Citro, Michele Aragona, Vito Cela, Stefano Del Prato, Alessandra Bertolotto
Summary: This study aimed to evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies. The study found that ART women had a significantly higher prevalence of GDM compared to women with spontaneous conception, and ART women above the age of 40 were more likely to develop GDM. Additionally, ART treatment appeared to be associated with an increased rate of preterm delivery, lower neonatal birth weight, and Apgar score, especially in women with GDM.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, General & Internal
Monique M. Hedderson, Sylvia E. Badon, Noel Pimentel, Fei Xu, Anne Regenstein, Assiamira Ferrara, Romain Neugebauer
Summary: This study compared the perinatal and neonatal outcomes of using glyburide and insulin to treat GDM in a clinical setting, and found no significant differences between the two in terms of outcomes.
Article
Endocrinology & Metabolism
Fanny Goyette, Bi Lan Wo, Marie-Helene Iglesias, Evelyne Rey, Ariane Godbout
Summary: The glycemic thresholds used to diagnose GDM are still a topic of debate. This study compared maternal and neonatal outcomes in women with mild hyperglycemia who were treated or left untreated. The results showed that treating women with mild hyperglycemia decreased the risk of adverse outcomes.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Miranda K. Kiefer, Matthew M. Finneran, Courtney A. Ware, Naleef Fareed, Joshua Joseph, Stephen F. Thung, Maged M. Costantine, Mark B. Landon, Steven G. Gabbe, Kartik K. Venkatesh
Summary: This study aims to investigate the association between the net decline in blood glucose from early to late pregnancy and adverse perinatal outcomes among women with pregestational diabetes. The results suggest that a reduction in blood glucose levels is associated with a lower risk of large for gestational age infants and neonatal hypoglycemia. However, there was no significant association with other adverse outcomes such as cesarean delivery and pre-eclampsia.
Review
Medicine, Research & Experimental
Duaa Ahmed Elhag, Souhaila Al Khodor
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. They have been found to be involved in the pathogenesis of gestational diabetes mellitus (GDM), and their aberrant expression in the placenta and/or maternal blood suggests their potential as biomarkers for early diagnosis and prognosis. Additionally, miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM, and their potential as diagnostic and therapeutic targets.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hiroshi Yokomichi, Mie Mochizuki, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Reiji Kojima, Tadao Ooka, Yuka Akiyama, Kunio Miyake, Sanae Otawa, Zentaro Yamagata
Summary: The aim of this study was to determine the risk of perinatal complications in mothers with non-normal glucose tolerance during delivery. The results showed that mothers with non-normal glucose tolerance had heavier placental weight, and mothers with type 1 and type 2 diabetes were more likely to have preterm birth, gestational hypertension, and neonatal jaundice. A positive result in a screening test for gestational diabetes suggested a medium-level risk of perinatal complications.
Article
Endocrinology & Metabolism
Jennifer Fu, George Tomlinson, Denice S. Feig
Summary: This study assesses perinatal outcomes among women with type 2 diabetes and analyzes gestational weight gain. The study found that restricted weight gain has both benefits and harms, highlighting the importance of comprehensive counseling for patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Public, Environmental & Occupational Health
Dongxin Lin, Dazhi Fan, Pengsheng Li, Gengdong Chen, Jiaming Rao, Zixing Zhou, Huishan Zhang, Xin Luo, Huiting Ma, Jingping Feng, Demei Lu, Lijuan Wang, Shiyan Lan, Caihong Luo, Xiaoling Guo, Zhengping Liu
Summary: The study found that twin pregnancies with GDM had comparable pregnancy and neonatal outcomes to those without GDM. Twin pregnancies with GDM and adequate prenatal care have similar perinatal outcomes to those without diabetes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Rana F. Chehab, Assiamira Ferrara, Mara B. Greenberg, Amanda L. Ngo, Juanran Feng, Yeyi Zhu
Summary: Glycemic control trajectories are associated with the risk of perinatal complications, with better glycemic control leading to lower risks.
Article
Clinical Neurology
Alexa X. D. Zhang, Holan Liang, Fiona S. McEwen, Charlotte Tye, Emma Woodhouse, Lisa Underwood, Elizabeth Shephard, Fintan Sheerin, Patrick F. Bolton
Summary: The study found that maternal tuberous sclerosis complex (TSC) is a significant marker of increased perinatal risk. However, after controlling for confounders, there was no significant association between perinatal adversities and neurodevelopmental outcomes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Alba Yuste Gomez, Maria del Pilar Ramos Alvarez, Jose Luis Bartha
Summary: This study found a relationship between dietary and lifestyle habits at the beginning of pregnancy and the later diagnosis of GDM.
Article
Public, Environmental & Occupational Health
Kaitlyn K. Stanhope, Naima T. Joseph, Marissa Platner, Ciara Hutchison, Shawn Wen, Adrienne Laboe, Katie Labgold, Denise J. Jamieson, Sheree L. Boulet
Summary: In a large public hospital, ICD-10 codes accurately identified cases of pregestational and gestational diabetes with low numbers of false positives.
Article
Ophthalmology
Felicia Widyaputri, Sophie L. Rogers, Edmund W. C. Khong, Alison J. Nankervis, Jennifer J. Conn, Muhammad B. Sasongko, Alexis Shub, Xavier J. Fagan, Daryl Guest, Robert C. A. Symons, Lyndell L. Lim
Summary: This study reports the prevalence of diabetic retinopathy (DR) and associated risk factors in pregnant women with pregestational diabetes during pregnancy and postpartum in Australia. The study found that the prevalence of DR during pregnancy was similar to that of the non-pregnant diabetic population, and approximately 1 in 9 participants had sight-threatening DR during pregnancy and the postpartum period.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Obstetrics & Gynecology
Heidi Sormunen-Harju, Saila Koivusalo, Mika Gissler, Johanna Metsala
Summary: Maternal obesity is associated with an increased risk of pregnancy complications, and this risk further increases in the second pregnancy. Additionally, first-pregnancy complications can impact the risk of complications in the second pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Chemistry, Medicinal
Asher Ornoy, Liza Weinstein-Fudim, Maria Becker
Summary: In this review, the functions and effects of three agents that induce epigenetic modifications were discussed. Valproic acid, S-adenosylmethionine, and choline have the ability to modify gene expression and potentially alleviate neurobehavioral changes in disorders with epigenetic origins. While valproic acid is a teratogen and should be avoided during pregnancy, additional studies are needed to explore the potential therapeutic use of these substances for epigenetic human diseases.
Article
Psychology, Multidisciplinary
Miri Tal-Saban, Asher Ornoy, Shula Parush
Summary: The study aimed to describe and assess the functioning of young adults with DCD in the Israel Defense Forces. Participants with probable DCD reported more difficulties in their military service. Significant differences were found between DCD groups and the control group in understanding of learning materials, forgetting belongings, and success in the army.
MILITARY PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Maria Becker, Karin Abaev, Albert Pinhasov, Asher Ornoy
Summary: Epigenetic changes play a significant role in various diseases, including psychiatric disorders like Autism Spectrum Disorder (ASD) and depression. Treatment with S-Adenosyl-Methionine (SAMe) during pregnancy improved depressive-like behavior and normalized gene expression related to depression in a mouse model. Gender differences were observed, which may explain the differences in clinical presentation of depression and treatment response between genders.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Oncology
Arkadi Hesin, Santosh Kumar, Valid Gahramanov, Maria Becker, Maria Vilenchik, Ilya Alexandrov, Julia Yaglom, Michael Y. Sherman
Summary: The main problem in treating advanced cancers is the metastatic spread of cancer cells. Current methods of monitoring metastasis in mouse models have low sensitivity and are not quantitative. Researchers developed a cell double-barcoding approach to monitor drug effects on tumors and metastasis, which is quantitative, highly sensitive, and highly reproducible. This approach can significantly enrich our understanding of drug effects in basic research and preclinical studies.
Article
Biochemistry & Molecular Biology
Maria Becker, Karin Abaev, Elena Shmerkin, Liza Weinstein-Fudim, Albert Pinhasov, Asher Ornoy
Summary: This study found that SAMe treatment increased serotonin levels in the prefrontal cortex of female Sub mice and increased dopamine and DOPAC levels in both males and females. SAMe also changed the expression of genes related to monoamine metabolism. These effects may explain the alleviation of depressive symptoms and suggest the beneficial effects of SAMe as an epigenetic modulator in the treatment of depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Eias Kassem, Wasef Na'amnih, Maanit Shapira, Asher Ornoy, Khitam Muhsen
Summary: Research has shown that overweight and obese children have worse metabolic and nutritional status, suggesting that metabolic syndrome may start in childhood.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Asher Ornoy, Denis Gorobets, Liza Weinstein-Fudim, Maria Becker
Summary: The etiology of autism spectrum disorder (ASD) involves genetic, environmental, and epigenetic factors. ASD is more common in males and there are distinct clinical, molecular, electrophysiological, and pathophysiological differences between sexes. Females with ASD exhibit fewer severe communication problems but more internalizing problems compared to males. There are also sex differences in brain structure, connectivity, and electrophysiology, and animal models suggest neurobehavioral differences between male and female animals. The mechanisms underlying these sex differences are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Developmental Biology
Asher Ornoy, Richard K. Miller
Summary: During early embryonic development, the yolk sac plays a crucial role in hematopoiesis and nutrition supply to the embryo/fetus. Damage to the yolk sac function can lead to embryonic malformations or even death. In rodents, various agents have been found to damage the yolk sac, affecting the development of the embryo/fetus. In humans, changes in yolk sac diameter have been associated with diabetic pregnancies and pregnancy loss, indicating the importance of the yolk sac in embryonic well-being.
BIRTH DEFECTS RESEARCH
(2023)
Meeting Abstract
Oncology
Arkadi Hesin, Santosh Kumar, Valid Gahramanov, Maria Becker, Maria Vilenchik, Ilya Alexandrov, Julia Yaglom, Michael Sherman
Meeting Abstract
Oncology
Arkadi Hesin, Santosh Kumar, Valid Gahramanov, Maria Becker, Maria Vilenchik, Ilya Alexandrov, Julia Yaglom, Michael Sherman
Meeting Abstract
Developmental Biology
A. Ornoy
BIRTH DEFECTS RESEARCH
(2022)