Article
Biochemistry & Molecular Biology
Agnieszka Trela-Makowej, Monika Leskiewicz, Jerzy Kruk, Andrzej Zadlo, Agnieszka Basta-Kaim, Renata Szymanska
Summary: This study compares the inhibition of lipid peroxidation by various tocochromanols in liposomes and demonstrates their potential neuroprotective role on a human neuroblastoma cell line. The results indicate the different biological activities of vitamin E homologues and suggest their potential application in treating neurodegenerative diseases.
Article
Chemistry, Applied
Levon Tavadyan, Sona Martoyan, Gaspar Kocharyan, Afaf Kamal-Eldin
Summary: Extended, chemically detailed kinetic models were used to study the reversal of antioxidant action of different tocopherols during methyl linoleate oxidation. The significant reactions contributing to the observed antioxidant and pro-oxidant behavior were identified. The findings reveal the complex relationship between antioxidant potency and concentration of tocopherols.
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Engineering, Environmental
Mohd Saleem, Qazi Fariduddin
Summary: Selenium is a beneficial element in plants, but its concentration between toxic and optimal levels is narrow and uneven. High concentrations of selenium cause oxidative stress and toxicity symptoms, affecting photosynthesis and growth, while low concentrations of selenium improve plant growth and photosynthetic traits.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agronomy
Silvia Campillos, Laia Jene, Sergi Munne-Bosch
Summary: This study investigated the effect of caffeine, a biostimulant, on the vitamin E content in lentils. Results showed an increase in α-tocopherol content when biostimulants were used in cultivation, but this effect was lost after cooking. Cooking also significantly reduced the α- and γ-tocopherol contents in lentils.
FOOD AND ENERGY SECURITY
(2023)
Article
Engineering, Environmental
Hongjing Zhao, Yu Wang, Yachen Liu, Kai Yin, Dongxu Wang, Baoying Li, Hongxian Yu, Mingwei Xing
Summary: The study focused on the toxic effects of Cypermethrin on grass carp, showing hepatotoxicity in terms of pathological changes, oxidative stress, and apoptosis in the liver. RNA-Seq analysis suggested that proteasome and oxidative phosphorylation pathways were compromised under CMN exposure, leading to toxic effects. In vitro studies further confirmed that proteasome pathway inhibition could protect against CMN-induced toxicity by enhancing antioxidative and anti-inflammatory capability.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Summary: This study found that isolevuglandins (isoLGs), formed from lipid peroxidation, covalently bind with amine-containing macromolecules in colonic epithelial cells of colorectal cancer (CRC) patients. The natural compound 2-hydroxybenzylamine (2-HOBA), a scavenger of electrophiles, was shown to reduce isoLG adduct levels, tumorigenesis, and oncogenic NRF2 activation in CRC models. In addition, 2-HOBA attenuated the growth of human CRC cells in animal models.
Article
Plant Sciences
Camila Ribalta-Pizarro, Paula Munoz, Sergi Munne-Bosch
Summary: This study investigated the content and composition changes of vitamin E in grape berries and leaves. It was found that the vitamin E content in leaves was higher than in fruits, with rich α-tocopherol in the skin and tocotrienols present only in seeds. During fruit ripening, the content of α-tocopherol decreased accompanied by an increase in lipid peroxidation. The changes in lipid peroxidation were negatively related to the variations in α-tocopherol content during fruit ripening.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Sakshi Verma, Smriti Batoye, Rajinder Jindal
Summary: This study investigated the protective role of naringenin (NG) against cadmium chloride (CdCl2) toxicity in Labeo rohita. Exposure to CdCl2 for 15 and 30 days induced adaptive mechanisms, but on the 60th day, oxidative damage was observed. Oral administration of NG restored altered levels of antioxidants and enzymes, suggesting a protective role against Cd-induced oxidative insult.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Obstetrics & Gynecology
Teppei Takeshima, Kimitsugu Usui, Kohei Mori, Takuo Asai, Kengo Yasuda, Shinnosuke Kuroda, Yasushi Yumura
Summary: Research has shown that there is a strong connection between oxidative stress and male infertility, leading to the proposal of the term Male Oxidative Stress Infertility (MOSI). Excessive reactive oxygen species (ROS) in ejaculate can lead to oxidative stress, which in turn can lower fertility through various mechanisms. Different assays are available for evaluating oxidative stress, such as the MiOXSYS (R) analyzer, and various measures can be considered for minimizing oxidative stress and improving clinical outcomes.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
S. Shehna Mahim, V. R. Anjali, V. S. Remya, S. Reshmi, C. Aruna Devi
Summary: The study investigates the effects of Bisphenol S(BPS) on fish and finds that sublethal exposure to BPS significantly influences the biomarker activities and leads to oxidative stress in fish. This indicates that BPS has oxidative potential.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Samukelisiwe C. Shabalala, Rabia Johnson, Albertus K. Basson, Khanyisani Ziqubu, Nokulunga Hlengwa, Sinenhlanhla X. H. Mthembu, Sihle E. Mabhida, Sithandiwe E. Mazibuko-Mbeje, Sidney Hanser, Ilenia Cirilli, Luca Tiano, Phiwayinkosi Dludla
Summary: This review investigates the pathological relevance of elevated lipid peroxidation products in type 2 diabetes (T2D), highlighting their potential role as biomarkers and therapeutic targets. It also briefly explains the significance of antioxidant enzymes/factors involved in blocking lipid peroxidation.
Article
Biochemistry & Molecular Biology
Michal Biernacki, Anna Jastrzab, Elzbieta Skrzydlewska
Summary: The study shows that topical application of CBD can regulate liver antioxidants and phospholipid metabolism to counteract oxidative stress and inflammation caused by UV radiation.
Article
Agriculture, Multidisciplinary
Boris Rabkin, Oren Tirosh, Joseph Kanner
Summary: The stomach acts as a bioreactor and plays a crucial role in biochemical reactions that impact human health. The oxidation of meat lipids in the stomach generates malondialdehyde (MDA), which is then absorbed into the bloodstream and modifies low-density lipoprotein (LDL) to MDA-LDL. The study found that vitamin E exhibits strong antioxidant activity against meat lipid oxidation in the stomach, especially at pH 3.0. The antioxidant activity of vitamin E at pH 3.0 is 20 times higher than that of catechin. Additionally, when combined with metmyoglobin (MbFe(+3)), vitamin E acts synergistically as a peroxidase/antioxidant couple, surpassing the antioxidant effect achieved by MbFe(+3)/catechin 150-fold. The continuous addition of low concentrations of vitamin E, catechin, and vitamin C helps maintain the meat's antioxidant activity, preventing lipid oxidation, reactive aldehyde generation, and loss of vitamin E.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Trela-Makowej, Jerzy Kruk, Malgorzata Jemiola-Rzeminska, Renata Szymanska
Summary: Several new fluorescent compounds were discovered in baobab seed oil during analysis, identified as a series of N-acylserotonins with antioxidant properties. These compounds showed significant inhibition of membrane lipid peroxidation and similar activity to delta-tocopherol in scavenging free radicals, indicating promising pharmacological activities.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Environmental Sciences
Beatrycze Nowicka
Summary: This review summarizes the knowledge of heavy metal toxicity, oxidative stress, and antioxidant response in eukaryotic algae. The types of ROS and their damage to cellular components are described, followed by detailed characterization of heavy metals, including their properties, sources of contamination, toxicity mechanisms, and stress symptoms. The review also covers low-molecular-weight antioxidants and ROS-detoxifying enzymes, their properties, cellular localization, and their occurrence in algae belonging to different clades. Additionally, other mechanisms providing tolerance to metal ions are briefly outlined at the end.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Forestry
Katarzyna Nawrot-Chorabik, Malgorzata Sulkowska, Malgorzata Osmenda, Vasyl Mohytych, Ewa Surowka, Dariusz Latowski
Summary: Fraxinus excelsior L. is threatened by various environmental factors, including fungi, heavy metal accumulation, and salinity. This study investigated the impact of these factors on European ash using in vitro techniques, revealing the strong pathogenic potential of fungi and the high toxicity of heavy metals.
Article
Biochemistry & Molecular Biology
Agnieszka Trela-Makowej, Monika Leskiewicz, Jerzy Kruk, Andrzej Zadlo, Agnieszka Basta-Kaim, Renata Szymanska
Summary: This study compares the inhibition of lipid peroxidation by various tocochromanols in liposomes and demonstrates their potential neuroprotective role on a human neuroblastoma cell line. The results indicate the different biological activities of vitamin E homologues and suggest their potential application in treating neurodegenerative diseases.
Review
Cell Biology
Jan Pukalski, Dariusz Latowski
Summary: Flavonoids are widely distributed chemical compounds found in plants and other kingdoms, and mushrooms have the ability to synthesize these compounds. However, it is not clear whether mushroom fruiting bodies can produce flavonoids. This article provides an overview of the research on flavonoids in mushrooms and proposes a research scheme to determine the synthesis ability of flavonoids in mushroom fruiting bodies.
Article
Biochemistry & Molecular Biology
Jerzy Kruk, Agnieszka Trela-Makowej, Renata Szymanska
Summary: Previously unknown compounds were discovered in lemon and other citrus species seeds, mainly saturated acyl-N omega-methylserotonins. These compounds exhibited antioxidant properties and were found in the inner seed coat.
Review
Plant Sciences
Beatrycze Nowicka
Summary: This article discusses the need for increased crop yield due to population growth and explores research on stimulating plant growth and improving stress tolerance through genetic engineering to modulate plant hormone metabolism.
Article
Plant Sciences
Beatrycze Nowicka, Jan Walczak, Maja Kapsiak, Karolina Barnas, Julia Dziuba, Aleksandra Suchon
Summary: In this study, the impact of different 1,4-naphthoquinone compounds on the antioxidant response of green algae was compared. The results showed that the redox properties and reduction potentials of these compounds influenced their pro-oxidant effects. High light intensity further enhanced the pro-oxidant effect of some compounds. These findings provide insights into the toxic mechanisms of these compounds on plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biophysics
Ewa Olbinska, Agnieszka Trela-Makowej, Weronika Larysz, Aleksandra Orzechowska, Renata Szymanska
Summary: This study investigated the effect of incorporating alpha-tocopherol into different carriers on the oxidative stability of oil in water emulsion. Results showed that alpha-tocopherol in liposomes and niosomes contributed to lower oxidation products compared to micelles. Additionally, the lipid peroxides remained stable in emulsions without alpha-tocopherol carriers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jerzy Kruk, Renata Szymanska
Summary: We describe a time-saving method for the chemical synthesis of polyprenols by chain lengthening. This method eliminates critical steps requiring low temperature and toxic chemicals, making it suitable for ordinary laboratories. A new approach using sodium acetylide in dimethoxyethane at room temperature was employed to replace the critical acetylene addition in liquid ammonia, resulting in the completion of the reaction within one hour. Our method offers reasonable yields and can be scaled as needed. High-performance liquid chromatography was used to monitor the reactions and control the formation of undesired isomers and side-products. The resulting polyprenols were successfully utilized in the synthesis of plastoquinones, and a new method for the direct formation of tocochromanols from polyprenols and aromatic head groups was discovered.
Article
Environmental Sciences
Bartosz Plucinski, Beatrycze Nowicka, Andrzej Waloszek, Joanna Rutkowska, Kazimierz Strzalka
Summary: The present study analyzed the protective mechanisms in Chlamydomonas reinhardtii strains adapted and not adapted for growth in the presence of elevated copper concentrations. The copper-adapted strains showed higher levels of antioxidants and photoprotective compounds, as well as increased peroxidase activity and more efficient non-photochemical quenching. These findings suggest that improving antioxidant defense and photoprotection may be crucial factors in the evolution of tolerance to heavy metals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)