Article
Food Science & Technology
Tong Wu, Shuailing Li, Yuqiu Huang, Zhen He, Ying Zheng, Antony Stalin, Qingsong Shao, Ding Lin
Summary: Anoectochilus roxburghii polysaccharides, an important bioactive component of the plant, exhibit anti-fatigue, anti-oxidation, and anti-hypoxia activities, suggesting their potential as functional food and medicine.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Yi Qiu, Wenbo Song, Ying Yang, Guojie Zhou, Yidan Bai, Toshihiro Akihisa, Feng Ye, Feng Feng, Wangshu Zhang, Jie Zhang
Summary: This article summarizes an important herbal medicine in China, Anoectochilus roxburghii, which has great medicinal and edible value. Polysaccharides, one of the main active components of A. roxburghii, have different structural characteristics and pharmacological activities depending on the sources and extraction methods. The review provides information on the extraction and purification methods, structural features, biological activities, and applications of A. roxburghii polysaccharides, as well as highlighting current research shortcomings and potential focus for future studies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Dongmei Tian, Xiaoyan Zhong, Liya Fu, Wanlong Zhu, Xin Liu, Zhigui Wu, Yue Li, Xue Li, Xuesen Li, Xuemei Tao, Qiming Wei, Xuping Yang, Yilan Huang
Summary: This study found that polysaccharides from Anoectochilus roxburghii can reduce blood glucose levels, improve oxidative stress and inflammation, and prevent diet-induced obesity and metabolic disorders. ARPs regulate energy balance by promoting fat thermogenesis via the AMPK/SIRT1/PGC-1 alpha signaling pathway.
Article
Food Science & Technology
Chen Li, Yunwei Wang, Zijia Huang, Yi Zhang, Jiao Li, Qing Zhang, Benjamin Kofi Simpson, Jingxue Wang
Summary: This study investigated the hypoglycemic and hypolipidemic effects of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. DOCP significantly decreased fasting blood glucose and insulin resistance, increased serum insulin content, reduced lipid levels, improved antioxidant capability, and protected liver and pancreas. DOCP also increased the diversity of intestinal flora and up-regulated the expression of key genes related to glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Cong Chen, Meisong Kang, Qiaowen Wang, Weilin Liu, Minguang Yang, Shengxiang Liang, Qing Xiang, Xiao Han, Jing Tao
Summary: The study demonstrated that ARP, EX, and the combination of ARP and EX could regulate lipogenesis, oxidative stress, and mitochondrial function in HFD mice. The synergistic effects of ARP and EX showed greater benefits in reducing ROS levels and increasing ATP content, suggesting their potential as interventions for obesity-induced metabolic disorders.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Medicinal
Liya Fu, Wanlong Zhu, Dongmei Tian, Yong Tang, Yun Ye, Qiming Wei, Chengbin Zhang, Wenqiao Qiu, Dalian Qin, Xuping Yang, Yilan Huang
Summary: This study found that ARPs can improve cognitive dysfunction induced by HFD by reducing the phosphorylation levels of Tau protein in the hippocampus, lowering body weight, blood glucose and cholesterol levels, and reducing inflammatory factors. In addition, ARPs also exert their effects by restoring intestinal barrier integrity and regulating gut microbiota.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Food Science & Technology
Hui Wang, Zhaojun Chen, Mei Wang, Mingxiu Long, Tingyuan Ren, Chao Chen, Xiaotong Dai, Sheng Yang, Shuming Tan
Summary: The study found that Rosa roxburghii fruit polyphenols extract (RPE) has hypoglycemic, hypolipidemic, and anti-inflammatory effects in streptozotocin (STZ)- and high-fat diet-induced type 2 diabetes mice. It also improves insulin resistance, lipid metabolism, and immune response, and modulates the composition and metabolic function of gut microbiota.
Article
Food Science & Technology
Yuan Fu, Liwen Wang, Guochuan Jiang, Lili Ren, Liyan Wang, Xuejun Liu
Summary: Auricularia cornea var. Li. polysaccharide (ACP) has potential application value in food engineering, pharmaceutical science, and health care due to its important biological activities. The extraction rate and purity of ACP are relatively high, and it has significant effects on reducing blood lipids and glucose, as well as enhancing antioxidant capacity. Moreover, ACP does not have significant adverse effects on organs and tissues.
Article
Pharmacology & Pharmacy
Hui Dang, Fengxia Li, Xuming Lin
Summary: This study found the potential anticataractous effect of Anoectochilus roxburghii on diabetic rats and its ability to suppress the activity of aldose reductase in the lens. Furthermore, it was found that Anoectochilus roxburghii can lower blood glucose levels, suppress aldose reductase activity, and slow down cataract development in diabetic rats.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Zheng Zhang, Boyun Yang, Jiaying Zhao, Anqi Xie, Lei Feng, Yiqun Wan
Summary: This study purified a sub-fraction of Anoectochilus roxburghii polysaccharide (ARPP-70) using anion exchange resin and obtained a homogeneous polysaccharide ARPP-70a. The structural features of ARPP-70a were characterized, and it showed significant antioxidant potential. This research improved the understanding of AR polysaccharide's physicochemical characteristics and its potential applications in the food and medicinal industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Chi-Feng Cheng, Chen-Wen Lu, Wen-Jhen Wu, Li-Yu Su, Thi Kim Ngan Nguyen, Szu-Chuan Shen, Chia-Ying Lien, Wu-Chang Chuang, Ming-Chung Lee, Chung-Hsin Wu
Summary: This study focused on the alleviating effects of Anoectochilus roxburghii extracts (AREs) on the adverse side effects of chemotherapy in mice with breast cancer. The results showed that ARE treatment can enhance the effects of chemotherapy and reduce its side effects.
Article
Biochemistry & Molecular Biology
Yanqing Zang, Chao Du, Xin Ru, Yang Cao, Feng Zuo
Summary: This study aimed to investigate the mechanisms of nature and modified 'Guanximiyou' pummelo peel pectin (GGP and MGGP) in alleviating T2DM through in vitro and in vivo. After modification, pectin was transformed from high methoxy pectin (HMP) to low methoxy pectin (LMP), and the content of galacturonic acid was increased. These made MGGP have stronger antioxidant capacity and better inhibition effect on corn starch digestion in vitro. In vivo experiments have shown that both GGP and MGGP inhibited the development of diabetes after 4 weeks of ingestion. However, MGGP can more effectively reduce blood glucose and regulate lipid metabolism, and has significant antioxidant capacity and the ability to promote SCFAs secretion. In addition, 16S rRNA analysis showed that MGGP changed the composition of intestinal microbiota in diabetic mice, decreased the abundance of Proteobacteria, and increased the relative abundance of Akkermansia, Lactobacillus, Oscillospirales and Ruminococcaceae. The phenotypes of the gut microbiome also changed accordingly, indicating that MGGP can inhibit the growth of pathogenic bacteria, alleviate intestinal functional metabolic disorders and reverse the potential risk of related complications. Altogether, our findings demonstrate that MGGP, as a dietary polysaccharide, may inhibit the development of diabetes by reversing the imbalance of gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yan-Lin Bin, Shun-Zhi Liu, Ting-Ting Xie, Wen-Zheng Feng, Hao-Yang Li, Zi-Jia Ye, Zhi-Hao Dong, Ying-Kun Qiu
Summary: In this study, three new compounds and 10 known compounds were isolated from the ethanol extract of Anoectochilus roxburghii. The structures of these compounds were characterized using various techniques. The isolated compounds exhibited potential antioxidant activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agricultural Engineering
Shangguo Feng, Kaixin Zheng, Yadi Gao, Zhenhao Zhang, Yanyun Jin, Wanting Lin, Ruoyun Ma, Kailin Hou, Hongshan Zhang, Xueshuang Liang, Cheng Chen, Zhijing Wang, Xiaori Zhan, Qicai Ying, Huizhong Wang, Chenjia Shen
Summary: Heavy metal toxicity is a significant issue for orchids. This study investigated the response mechanism of Anoectochilus genus to heavy metal stress, and identified key genes and transcription factors involved in tolerance. These findings contribute to breeding orchids with better adaptability to adverse environments.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Nutrition & Dietetics
Xiaoling Huang, Kunxi Ouyang, Yongzhi Luo, Guohong Xie, Yuesheng Yang, Junjie Zhang
Summary: This study analyzed and compared the differences in morphological and biological characteristics between diploid and tetraploid Anoectochilus roxburghii plants. It found significant differences in characteristics such as plant size, root structure, and biochemical composition between the two types.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)