Article
Cardiac & Cardiovascular Systems
Takuma Ishibashi, Hidehiro Kaneko, Satoshi Matsuoka, Yuta Suzuki, Kensuke Ueno, Ryusei Ohno, Akira Okada, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: The aim of this study was to investigate the association between fasting plasma glucose, HDL cholesterol levels, and clinical outcomes. The findings suggest that there is a U-shaped association between HDL cholesterol and clinical outcomes, and this association is amplified with worsening glucose tolerance.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Yuyang Ye, Yuya Kawaguchi, Asahi Takeuchi, Ni Zhang, Ryosuke Mori, Maihemuti Mijiti, Arata Banno, Toshitaka Okada, Naoto Hiramatsu, Satoshi Nagaoka
Summary: The study investigated the effects of rose polyphenols (ROSE) on lipid metabolism and antiobesity. It was found that ROSE significantly decreased body weight gain, adipose tissue weight, serum cholesterol, and hepatic triglyceride concentrations, while increasing fecal triglyceride. The study suggests that rose polyphenols play a role in inhibiting lipid synthesis and promoting lipolysis.
NUTRITION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kate N. O'Neill, Emily Aubrey, Laura D. Howe, Evie Stergiakouli, Santiago Rodriguez, Patricia M. Kearney, Linda M. O'Keeffe
Summary: This study investigated the relationship between common European mitochondrial DNA haplogroups (H, U, J, T, K, V, W, I, and X) and cardiometabolic risk factors. The results showed that, except for haplogroups V and X in females, there was no significant association between other haplogroups and risk factors.
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Chelsea L. Nora, Liyue Zhang, Robert J. Castro, Amanda Marx, Hannah B. Carman, Tiffany Lum, Sotirios Tsimikas, Mee Young Hong
Summary: This study aimed to determine the effects of consuming 42.5 g/day of mixed nuts on LDL-C, Lp(a), and inflammatory markers in individuals with overweight or obesity. The study found that consuming mixed nuts did not significantly affect LDL-C or Lp(a), but it could reduce body fat percentage, diastolic blood pressure, and increase adiponectin levels.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Ruicheng Shi, Wei Lu, Ye Tian, Bo Wang
Summary: Through the study of Sec16b mice, it was found that intestinal SEC16B plays a key role in regulating obesity and lipid absorption induced by high-fat diet.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Laura Montani
Summary: This article discusses the important role of lipids in the formation and maintenance of myelin, as well as their association with neurodegenerative diseases. Lipids act not only as structural building blocks, but also as signaling molecules driving cell proliferation and differentiation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shelby M. Flaherty, Elizabeth K. Wood, Carol D. Ryff, Gayle D. Love, Theodoros Kelesidis, Loni Berkowitz, Guadalupe Echeverria, Katherine Rivera, Attilio Rigotti, Christopher L. Coe
Summary: This study provides a comprehensive understanding of HDL function in a racially and metabolically diverse adult population, finding differences in HDLperox content among individuals with type 2 diabetes and nondiabetic white males.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Rohit Hariharan, Emmanuel Nene Odjidja, David Scott, Nitin Shivappa, James R. Hebert, Allison Hodge, Barbora de Courten
Summary: Research suggests that an unhealthy diet is associated with an increased risk of obesity, T2DM, and CVD, but there is limited research on the association between dietary inflammation and T2DM and its risk factors, as well as a lack of interventional studies designed to change the inflammatory potential of diets and study its effect on cardiometabolic risk factors and diseases. Interventions studies are recommended to assess whether changes in DII can independently modulate cardiometabolic risk factors and diseases.
Article
Medicine, General & Internal
Elahe Zare Borzeshi, Majid Valizadeh, Mohammad Hossein Panahi, Davood Khalili, Mostafa Mousavizadeh, Yadollah Mehrabi
Summary: This study proposes a data-driven framework for classifying individuals at risk of cardiovascular outcomes based on obesity and metabolic syndrome. By analyzing a population-based cohort study, 8 distinct endophenotypes were identified with significant differences in clinical characteristics and outcomes.
Article
Nutrition & Dietetics
Sanju Bhattarai, Rikke Nerhus Larsen, Archana Shrestha, Biraj Karmacharya, Abhijit Sen
Summary: This study examined the association between socioeconomic factors and overweight/obesity in rural Nepal. The results showed that individuals with higher education and income, as well as unemployment, had a higher prevalence of overweight/obesity. Compared to those with low income and no formal education, the prevalence ratio of overweight/obesity was 1.69 and 2.27 times higher for those with high income and high school education or above, respectively. No evidence of modification by gender and age was observed in the association between socioeconomic factors and overweight/obesity.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Soheila Abachi, Genevieve Pilon, Andre Marette, Laurent Bazinet, Lucie Beaulieu
Summary: This article focuses on recent studies on hypoglycemic, lipid-lowering, cholesterol-lowering, and anti-obesity fish peptides. The aim is to provide more knowledge for the design and discovery of anti-MetS compounds by comparing different extraction, isolation, and purification methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Environmental Sciences
Sanda Umar Ismail, Evans Atiah Asamane, Hibbah Araba Osei-Kwasi, Daniel Boateng
Summary: There is little agreement on the role of socioeconomic factors in the development of cardiovascular diseases, obesity, and diabetes among migrants in the UK. This systematic review examined existing evidence on this association and found a trend towards a link between socioeconomic factors and these health conditions. However, the relationship became more complex when specific variables and migrant subgroups were analyzed. Further research is needed to fully understand the exact association between socioeconomic factors and cardiovascular diseases, obesity, and diabetes among migrants in the UK.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Peripheral Vascular Disease
Janis M. Nolde, Thomas Beaney, Revathy Carnagarin, Aletta E. Schutte, Neil R. Poulter, Markus P. Schlaich
Summary: Universal lowering of blood pressure thresholds for defining hypertension would have a tremendous impact on hypertension prevalence globally, with significant disparities between countries and substantial heterogeneity in phenotypic and demographic patterns. These findings should be confirmed in dedicated population studies.
Review
Agriculture, Multidisciplinary
Fan Zhang, Junhua Li, Cuihua Chang, Luping Gu, Wen Xiong, Yujie Su, Yanjun Yang
Summary: This review discusses the contradictory conclusions about the relationship between egg consumption and cardiovascular disease (CVD) risk, as well as the effects of egg cholesterol intake on cholesterol homeostasis. The study finds that moderate egg consumption has no substantial overall impact on cholesterol homeostasis in healthy individuals. However, excessive cholesterol intake is not recommended for individuals with metabolic disorders. In the future, the impact of egg consumption on CVD risk should be considered from different perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Julia Otten, Bjorn Tavelin, Stefan Soderberg, Olov Rolandsson
Summary: The study found an association between increased fasting C-peptide levels at type 2 diabetes diagnosis and total and cancer-related mortality. Additionally, increased HbA1c levels at diabetes diagnosis were associated with overall mortality, major cardiovascular events, stroke, and retinopathy.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Clinical Neurology
Kristina Norman, Marie Eriksson, Mia von Euler
Summary: This study investigates sex differences and longitudinal changes in ischemic stroke in the younger population. The results show that men have a higher incidence than women, and certain risk factors such as atrial fibrillation, diabetes, and smoking are more common in men. The incidence of ischemic stroke stabilizes and then decreases over time, but fluctuations are substantial due to its rarity in the younger population.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pediatrics
Kristina Klinto, Marie Eriksson, Avni Abdiu, Karin Brunnegard, Jenny Cajander, Emilie Hagberg, Malin Hakelius, Christina Havstam, Hans Mark, Asa Okhiria, Petra Peterson, Kristina Svensson, Magnus Becker
Summary: The aim of this study was to compare data from the Swedish cleft lip and palate registry (CLP registry) among six treatment centers regarding surgery and speech outcomes at 5 years old. The results showed that at one center, more children underwent a higher number of surgeries and achieved poorer speech outcomes. It was also found that performing the last primary palatal surgery after 25 months of age increased the risk of negative speech results.
Article
Cardiac & Cardiovascular Systems
Linn Skoglund Larsson, Johan Ljungberg, Lars Johansson, Bo Carlberg, Stefan Soderberg, Mattias Brunstrom
Summary: This study aimed to compare mortality in patients with ascending aortic surgery with matched controls. The results showed higher mortality in surgical patients, both in the short-term and long-term postoperative period, with a significant portion of deaths attributed to aortic disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Multidisciplinary Sciences
Anita Lindmark, Marie Eriksson, David Darehed
Summary: The study found that low education was associated with an increased risk of severe stroke, and almost one third of this association was explained by risk factors, while the indirect effect via stroke prevention drugs was negligible. This suggests that efforts to reduce risk factors are important in decreasing stroke severity among those with low socioeconomic status.
Article
Cardiac & Cardiovascular Systems
Betul Toprak, Stephanie Brandt, Jan Brederecke, Francesco Gianfagna, Julie K. K. Vishram-Nielsen, Francisco M. Ojeda, Simona Costanzo, Christin S. Borschel, Stefan Soderberg, Ioannis Katsoularis, Stephan Camen, Erkki Vartiainen, Maria Benedetta Donati, Jukka Kontto, Martin Bobak, Ellisiv B. Mathiesen, Allan Linneberg, Wolfgang Koenig, Maja-Lisa Lochen, Augusto Di Castelnuovo, Stefan Blankenberg, Giovanni de Gaetano, Kari Kuulasmaa, Veikko Salomaa, Licia Iacoviello, Teemu Niiranen, Tanja Zeller, Renate B. Schnabel
Summary: The study aims to find reliable circulating predictors for incident atrial fibrillation (AF) using classical regressions and machine learning techniques. Fourteen routinely available biomarkers reflecting different pathophysiological pathways were examined in relation to incident AF. NT-proBNP was identified as the strongest blood-based predictor of incident AF.
Article
Biochemistry & Molecular Biology
Tina Haase, Christian Mueller, Bastian Stoffers, Philipp Kirn, Melanie Waldenberger, Frank J. Kaiser, Mahir Karakas, Sangwon Kim, Svenja Voss, Philipp S. Wild, Karl J. Lackner, Jonas Andersson, Stefan Soederberg, Diana Lindner, Tanja Zeller
Summary: Using a translational approach, this study identified and characterized the role of GPR15 gene in early-onset myocardial infarction (MI). Increased expression of GPR15 was associated with atherosclerosis, inflammation, impaired cardiac function, and smoking. Methylation levels of GPR15 sites were lower in MI patients, and a specific GPR15 polymorphism was associated with early-onset MI. Experimental validation confirmed the upregulation of Gpr15 in ischemic conditions and its impact on survival rates and gene expression in response to MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Eriksson, Anton Grundberg, Erik Inge, Mia von Euler
Summary: This study aimed to estimate and compare the risk of stroke recurrence in men and women, taking into account the competing risk of death. The findings showed that the risk of stroke recurrence has decreased in both men and women, but women's higher age and other risk factors contribute to their higher risk compared with men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kerstin Welen Schef, Per Tornvall, Joakim Alfredsson, Emil Hagstrom, Annica Ravn-Fischer, Stefan Soderberg, Troels Yndigegn, Tomas Jernberg
Summary: The objective of this study was to assess the prevalence of angina pectoris symptoms and investigate their relationship with coronary atherosclerosis in a middle-aged general population. The results showed that angina symptoms were common among the general population of Sweden, but were not strongly associated with obstructive coronary atherosclerosis. Sociodemographic and psychological factors were found to be highly associated with angina symptoms, regardless of the degree of coronary atherosclerosis.
Article
Medicine, Research & Experimental
Marja Lisa Byhamre, Mats Eliasson, Stefan Soederberg, Patrik Wennberg, Viktor Oskarsson
Summary: Snus, a common tobacco product in Sweden, has been found to be associated with higher levels of HDL cholesterol and triglycerides compared to non-tobacco use, and higher levels of HDL cholesterol and lower levels of triglycerides compared to cigarette smoking. However, there was no association between snus use and non-HDL cholesterol levels. Further studies are needed to validate these findings.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Clinical Neurology
Ilan Ben-Shabat, David Darehed, Marie Eriksson, Jonatan Salzer
Summary: This study examined the characteristics of patients with in-hospital stroke (IHS) in Sweden, including the reason for hospitalization and invasive procedures before the stroke. The results showed that 5.4% of stroke cases occurred during hospitalization, and 46.7% of IHS patients had at least one invasive procedure prior to the stroke. The study suggests the need for further research on the absolute risks of stroke after surgical procedures and ways to reduce the risk.
EUROPEAN STROKE JOURNAL
(2023)
Article
Medicine, General & Internal
Julia de Man Lapidoth, Johan Hultdin, P. Andreas Jonsson, Maria Eriksson Svensson, Maria Wennberg, Tanja Zeller, Stefan Soderberg
Summary: This study aimed to investigate the effect of classical cardiovascular disease risk factors on renal function over the past few decades. The findings revealed a gradual decline in renal function in Northern Sweden between 1986 and 2014. This study underscores the importance of close association between CKD and CVD, as well as the need for continuous monitoring and management of risk factors affecting renal function.
Article
Rheumatology
Erik Hulander, Tatiana Zverkova Sandstrom, Jeannette Beckman Rehnman, Lucy Law, Stefan Soderberg, Helena Forsblad-d'Elia
Summary: This study assessed the dietary nutrient intake in patients with r-axSpA and compared it to persons without r-axSpA. The results showed that the patients had impaired dietary intake, particularly in nutrients with anti-inflammatory properties. Therefore, it is suggested to incorporate nutrition screening into the management of r-axSpA patients.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Hina Taki, Jaakko Tuomilehto, Paul Zimmet, Abdonas Tamosiunas, Sudhir Kowlessur, Dianna J. Magliano, Jonathan E. Shaw, Stefan Soederberg, Ulf Nilsson
Summary: LVH is more common in individuals with hypertension, African ancestry, and/or low education level. These individuals are usually older, more likely to have hypertension, diabetes, known cardiovascular disease, and elevated levels of cholesterol and creatinine. Creole ethnicity, low education level, hypertension, known CVD, and elevated creatinine are associated with LVH. Individuals with untreated or uncontrolled hypertension are at a higher risk for LVH than those with well-controlled hypertension or normotension.
Article
Cardiac & Cardiovascular Systems
Therese Andersson, Lars Nilsson, Flemming Larsen, Bo Carlberg, Stefan Soderberg
Summary: This study aimed to follow a cohort of patients with pulmonary embolism (PE) to generate information about long-term symptoms and investigate the prevalence of chronic thromboembolic pulmonary hypertension (CTEPH). The study found that the overall prevalence of CTEPH in Sweden in 2005 was 0.4%, while the prevalence among survivors was higher at 0.7%. The cumulative incidence of CTEPH in patients who underwent a V/Q scan was 1.1%.
PULMONARY CIRCULATION
(2023)
