Article
Cardiac & Cardiovascular Systems
Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund
Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan
Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Physiology
Olivia K. Travis, Geilda A. Tardo, Chelsea Giachelli, Shani Siddiq, Henry T. Nguyen, Madison T. Crosby, Tyler D. Johnson, Andrea K. Brown, George W. Booz, Alex N. Smith, Jan Michael Williams, Denise C. Cornelius
Summary: In this study, neutralization of IFNy was found to reduce MAP, UARI, and placental ROS levels in RUPP recipients. However, fetal and placental weights in RUPP rats were not improved following anti-IFNy treatment. These findings suggest that IFNy may play a role in the pathophysiology of PE and could be a potential therapeutic target for improving maternal outcomes in PE.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Wanying Cheng, Lingling Wang, Xin Gao, Guangli Yin, Jujuan Wang, Yongqian Shu, Hongxia Qiu, Limin Duan
Summary: sFLt-1 is a reliable immune biomarker for predicting the inflammatory status and prognosis of secondary hemophagocytic lymphohistiocytosis (sHLH).
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang
Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura
Summary: In early pregnancy, the sFlt-1/PlGF ratio may be used to differentiate between exacerbation of systemic lupus erythematosus and preeclampsia.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xinwen Chang, Qizhi He, Mengtian Wei, Linyan Jia, Yingying Wei, Yiding Bian, Tao Duan, Kai Wang
Summary: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) have beneficial effects on adverse birth outcomes in a preeclampsia mouse model induced by sFlt-1. They can decrease blood pressure, improve fetal birth weight, and restore placental vascular networks. In addition, HUCMSC-exos partially rescue sFlt-1-induced dysfunction of human umbilical vein endothelial cells.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qing Yong, Kyra L. Dijkstra, Carin van der Keur, Jan A. Bruijn, Michael Eikmans, Hans J. Baelde
Summary: Insufficient immune tolerance during pregnancy is associated with pathological conditions such as preeclampsia (PE). The expression of sFLT1 protein in human placenta is regulated by MIF during early pregnancy and preeclampsia. sFLT1 plays an important role in the modulation of inflammation in early pregnancy and preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang
Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.
CLINICA CHIMICA ACTA
(2022)
Article
Cardiac & Cardiovascular Systems
Lise Lotte Torvin Andersen, Annemarie Helt, Lene Sperling, Martin Overgaard
Summary: The study evaluated the predictive performance and decision threshold of Kryptor sFlt-1/PlGF ratio in managing women with symptoms of preeclampsia, showing good predictive value for both early-onset and late-onset preeclampsia. A single threshold of 66 is recommended for clinical use in ruling out and ruling in preeclampsia within 1 week.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Katarzyna Pankiewicz, Ewa Szczerba, Anna Fijalkowska, Janusz Sierdzinski, Tadeusz Issat, Tomasz Mikolaj Maciejewski
Summary: This case-control observational study evaluates the influence of concomitant gestational diabetes mellitus (GDM) on the severity of preeclampsia (PE). The study found that the coexistence of GDM may mitigate the course of PE. Furthermore, there were no differences in serum levels of studied biomarkers between patients with PE with and without GDM, suggesting their usefulness in the diagnosis and management of PE in patients with coexisting GDM.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jakub Kornacki, Przemyslaw Wirstlein, Ewa Wender-Ozegowska
Summary: Evaluation of serum concentrations of HA in patients with PE was found to be more useful in the assessment of endothelial injury, compared to the assessment of SDC-1. The degree of EG damage was comparable in patients with early- and late-onset PE. The pathomechanism of the damage seems to be more sFlt-1 dependent in patients with early- onset PE than in the case of late-onset disease.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Fabienne Trottmann, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Araceli Jarquin Campos, Franz H. Messerli, Lorenz Risch, Marc U. Baumann
Summary: In this study, pregnant women with AFLP had significantly higher sFlt-1 levels compared to those with HELLP syndrome. PlGF levels were also higher in AFLP patients. The sFlt-1 cutoff value of 31,100 pg/mL showed a sensitivity and specificity of 100% in distinguishing between AFLP and HELLP syndrome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Biochemistry & Molecular Biology
Daria Monogiou Belik, Riccardo Bernasconi, Lifen Xu, Giacomo Della Verde, Vera Lorenz, Vivienne Gruterich, Melania Balzarolo, Michika Mochizuki, Otmar Pfister, Gabriela M. Kuster
Summary: This study aimed to test whether Flt3-targeting TKI treatment aggravates cardiac injury after myocardial infarction (MI). The results showed that quizartinib did not alter cardiac dimensions or function in healthy mice, but significantly enhanced ventricular dilatation and apoptotic cell death in MI mice. In vitro studies further confirmed that quizartinib increased cell death and apoptosis, potentially through a p38-dependent mechanism.
Article
Obstetrics & Gynecology
Ele Hanson, Kristiina Rull, Kaspar Ratnik, Pille Vaas, Pille Teesalu, Maris Laan
Summary: The study aimed to evaluate the value of screening for maternal serum sFlt-1/PlGF ratio in predicting the development of preeclampsia during the third trimester. The results showed that testing sFlt-1/PlGF ratio between 180-259 gestational days could detect approximately half of subsequent preeclampsia cases, with the highest detection rate observed at 225-238 gestational days.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shigeru Saito, Kenichi Takagi, Junji Moriya, Takao Kobayashi, Naohiro Kanayama, Hiroshi Sameshima, Mamoru Morikawa, Haruhiko Sago, Tomoko Adachi, Akihide Ohkuchi, Satoru Takeda, Hisashi Masuyama, Hiroyuki Seki
Summary: This study protocol aims to evaluate the efficacy of recombinant human antithrombin gamma in treating early-onset severe de novo preeclampsia. By selecting a specifically defined target population based on reanalysis of previous data, the study is expected to provide valuable efficacy and safety data for Japanese patients.
CONTEMPORARY CLINICAL TRIALS
(2021)
Article
Peripheral Vascular Disease
Ayae Ozeki, Yuka Oogaki, Yuka Henmi, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi, Akihide Ohkuchi, Koumei Shirasuna
Summary: This study found that S100A9 is associated with the pathogenesis of hypertensive disorders of pregnancy and can activate the NLRP3 inflammasome. Animal experiments also confirmed that injection of S100A9 can cause hypertension and neutrophil accumulation in pregnant mice.
JOURNAL OF HYPERTENSION
(2022)
Article
Obstetrics & Gynecology
Masako Hayashi, Rie Oi, Katsufumi Otsuki, Noriko Yoneda, Takeshi Nagamatsu, Ryota Kumasaka, Kei Miyakoshi, Hiroaki Aoki, Kei Tanaka, Kazumasa Kumazawa, Akihide Ohkuchi, Yoshio Matsuda, Akihito Nakai
Summary: Vaginal progesterone reduces preterm birth rates among women with mild cervical shortening, despite not preserving cervical length; expanding progesterone treatment indications to include both high-risk and low-risk populations may be beneficial.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Keiko Kagawa, Hironori Takahashi, Shiho Nagayama, Kenji Horie, Kayo Takahashi, Yosuke Baba, Manabu Ogoyama, Hirotada Suzuki, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
Summary: This study investigated the short/long-term outcomes of fetuses/neonates with ameliorated cystic hygroma during pregnancy and found that half of them had good outcomes while the other half had abnormalities. Fetuses with a nuchal thickness >5mm at diagnosis may be more likely to have abnormalities.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Mai Ohashi, Hironori Takahashi, Yosuke Baba, Hirotada Suzuki, Shiho Nagayama, Kenji Horie, Manabu Ogoyama, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara
Summary: This study focused on patients with retained products of conception in placenta previa and found that patients with hypervascular RPOC and higher bleeding episodes during cesarean section were more likely to require transarterial embolization and/or hysterectomy after cesarean section.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Hironori Takahashi, Yosuke Baba, Rie Usui, Hirotada Suzuki, Kenji Horie, Hitoshi Yano, Akihide Ohkuchi, Shigeki Matsubara
Summary: The combination of MT-holding, IUB, and UCS in patients with placenta previa has been shown to significantly reduce postpartum hemorrhage and the need for blood transfusion. Further studies are needed to determine the best combination of hemostatic procedures for placenta previa.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Peripheral Vascular Disease
Akihide Ohkuchi, Atsuhiro Ichihara
HYPERTENSION RESEARCH
(2022)
Article
Obstetrics & Gynecology
Manabu Ogoyama, Hironori Takahashi, Yosuke Baba, Hiromichi Yamamoto, Kenji Horie, Shiho Nagayama, Hirotada Suzuki, Rie Usui, Akihide Ohkuchi, Shigeki Matsubara, Hiroyuki Fujiwara
Summary: This study aimed to investigate whether low-risk total placenta previa (PP) patients bleed more than partial/marginal PP patients. The results showed that prior cesarean section (CS), anterior placenta, and placental lacunae on ultrasound were risk factors for bleeding-related poor outcomes in total PP patients. However, low-risk total PP patients without these three factors had similar bleeding-related poor outcomes as partial/marginal PP patients.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Review
Cell Biology
Manabu Ogoyama, Hironori Takahashi, Hirotada Suzuki, Akihide Ohkuchi, Hiroyuki Fujiwara, Toshihiro Takizawa
Summary: Preeclampsia (PE) is a dangerous condition with challenges in treatment and prevention. Research suggests that identifying maternal circulating non-coding RNAs (ncRNAs) in early pregnancy may help predict the development of PE.
Article
Peripheral Vascular Disease
Akihide Ohkuchi, Hirotada Suzuki, Keiichi Matsubara, Kazushi Watanabe, Takuya Saitou, Hideyuki Oda, Soichiro Obata, Shinya Kondo, Kiyoshi Noda, Junya Miyoshi, Satoru Ikenoue, Makoto Nomiyama, Hiroyuki Seki, Sachi Sukegawa, Satoshi Ichigo, Hirofumi Ando, Chiho Fuseya, Takuya Shimomura, Rika Suzuki, Kazuya Mimura, Ichiro Yasuhi, Masashi Fukuda, Sumiko Hara, Ryuhei Kurashina, Arihiro Shiozaki, Shigeki Matsubara, Shigeru Saito
Summary: This study investigated whether there were dual peaks in the gestational-age-specific incidence or prevalence of early-onset preeclampsia, and concluded that there were no dual peaks, refuting the previous rationale of defining early-onset preeclampsia as occurring before 32 weeks of gestation.
HYPERTENSION RESEARCH
(2022)
Article
Obstetrics & Gynecology
Kenji Horie, Kayo Takahashi, Makiko Mieno, Shiho Nagayama, Hiroaki Aoki, Takeshi Nagamatsu, Ayumi Kanatani, Hironobu Hyodo, Kayoko Terada, Masako Hayashi, Akihito Nakai, Noriko Yoneda, Shigeru Saito, Yoshio Matsuda, Shigeki Matsubara, Akihide Ohkuchi
Summary: This study compared the risk of spontaneous preterm birth (SPTB) before 35 weeks in symptomatic and asymptomatic women with cervical shortening at 16-34 weeks under mid-trimester universal screening of cervical length (CL). The results showed that the presence of uterine contractions at admission may not be an independent risk factor for the occurrence of SPTB before 35 weeks, while CL of 1-9 mm, CL of 10-14 mm, and vaginal bleeding at admission were identified as independent risk factors for SPTB before 35 weeks.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Chikako Hirashima, Kazuya Mimura, Takako Ohmaru-Nakanishi, Kohei Kotera, Kayo Takahashi, Shigeru Saito, Hiroyuki Seki, Kazushi Watanabe, Katsuhiko Naruse, Shintaro Makino, Hirohito Metoki, Shigeki Matsubara, Atsuhiro Ichihara, Akihide Ohkuchi
Summary: This study aimed to investigate the prevalence of chronic hypertension, white coat hypertension, and masked hypertension in pregnant women at <20 weeks of gestation. The results showed that the prevalence of chronic hypertension, white coat hypertension, and masked hypertension were 11%, 30%, and 2% respectively. The incidence of preeclampsia in women with chronic hypertension was 20%, and the incidence of gestational hypertension and preeclampsia in women with white coat hypertension were 0% and 17% respectively.
HYPERTENSION RESEARCH IN PREGNANCY
(2022)
Meeting Abstract
Developmental Biology
Shohei Tozawa, Syunya Noguchi, Takanobu Sakurai, Akihide Ohkuchi, Hironori Takahashi, Hiroyuki Fujiwara, Toshihiro Takizawa
Meeting Abstract
Developmental Biology
Airi Hirooka, Yuka Oogaki, Ayae Ozeki, Hironori Takahashi, Akihide Ohkuchi, Koumei Shirasuna
Meeting Abstract
Developmental Biology
Manabu Ogoyama, Junxiao Wang, Dongwei Zhao, Hironori Takahashi, Shigeki Matsubara, Akihide Ohkuchi, Toshihiro Takizawa