Article
Endocrinology & Metabolism
Takuya Iwasawa, Toshifumi Takahashi, Eri Maeda, Koichi Ishiyama, Satoshi Takahashi, Ryota Suganuma, Koki Matsuo, Masahito Tachibana, Rie Fukuhara, Hiromitsu Shirasawa, Wataru Sato, Yukiyo Kumazawa, Yukihiro Terada
Summary: The localization of adenomyotic lesions has an impact on the outcomes of IVF/ICSI-ET cycles. MRI assessments of adenomyosis in infertile patients are beneficial, and treatment plans should be considered based on the localization of adenomyotic lesions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ningxin Qin, Zhiyang Zhou, Wenlong Zhao, Kexin Zou, Weihui Shi, Chuanjin Yu, Xia Liu, Zehan Dong, Yiting Mao, Xinmei Liu, Jianzhong Sheng, Guolian Ding, Yanting Wu, Hefeng Huang
Summary: This study explored the impact of frozen and thawed embryo transfer (FET) on the glucose metabolism of offspring using a mouse model. Male mouse offspring conceived through FET showed impaired glucose tolerance and insulin resistance, along with disruption of hepatic insulin signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Shi-Bin Chao, Yan-Hong Wang, Jian-Chun Li, Wen-Ting Cao, Yun Zhou, Qing-Yuan Sun
Summary: This study investigated the impact of a novel endometrial preparation approach (DROI) on the clinical pregnancy rate of single frozen-thawed blastocyst transfer and compared it with hormone replace treatment (HRT). The results showed that the DROI group had significantly higher clinical pregnancy rate and ongoing pregnancy rate compared to the HRT group, suggesting that DROI may be a more efficient and promising alternative for endometrial preparation in frozen-thawed blastocyst transfer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Wenjing Zhou, Zhaojun Cheng, Chong Wang, Ying Feng
Summary: Sequential transplantation is a new mode of in vitro fertilization and embryo transfer. This study compared the clinical outcomes of sequential transplantation, embryo transplantation, and blastocyst transplantation in freeze-thaw embryo transfer cycles. The results showed that the sequential transplantation group had a significantly higher number of transplanted embryos than the other two groups, and the blastocyst transplantation group had the highest implantation rate. The sequential transplantation cycle can achieve a higher clinical pregnancy rate and minimize wastage of transplanted embryos, making it a viable choice for some patients in resuscitation transplantation cycles.
Article
Obstetrics & Gynecology
Reeva Makhijani, Prachi Godiwala, James Grady, Alicia Christy, Kim Thornton, Daniel Grow, Lawrence Engmann
Summary: This retrospective cohort study aimed to evaluate if racial/ethnic differences persist in pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. The results showed that Black women had a significantly lower live birth rate and implantation rate, as well as higher clinical loss rate compared to other racial/ethnic groups.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Sylvie Epelboin, Julie Labrosse, Jacques De Mouzon, Aviva Devaux, Marie-Jose Gervoise-Boyer, Laetitia Hesters, Philippe Jonveaux, Rachel Levy, Nathalie Sermondade, Patricia Fauque, Fabienne Pessione
Summary: This nationwide cohort study in France found that ovulatory cycle frozen embryo transfer (OC-FET) can reduce the risk of gestational hypertension and other vascular disorders in pregnant women compared to artificial cycle frozen embryo transfer (AC-FET) and fresh embryo transfer (fresh-ET). This suggests that OC-FET can serve as a protective factor for preventing maternal vascular pathologies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiangman Gao, Yifeng Yuan, Jia Li, Tian Tian, Ying Lian, Ping Liu, Rong Li, Jie Qiao, Xiaoyu Long, Haiyan Wang
Summary: Sequential embryo transfer in frozen-thawed embryo transfer cycles can improve the clinical outcomes of patients with RIF, including implantation rate, clinical pregnancy rate, and multiple pregnancy rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Lin Song, Zhiqin Bu, Yingpu Sun
Summary: This study aimed to investigate the relationship between endometrial thickness and early pregnancy complications in frozen thawed embryo transfer cycles. The results showed that thin endometrium was associated with an increased risk of ectopic pregnancy and early spontaneous miscarriage. Therefore, endometrial thickness can serve as an independent predictor for early pregnancy complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Adva Aizer, Meirav Noach-Hirsh, Olga Dratviman-Storobinsky, Ravit Nahum, Ronit Machtinger, Yuval Yung, Jigal Haas, Raoul Orvieto
Summary: This study examined the effect of COVID-19 infection or vaccination on frozen-thawed embryo transfer (FET), and found that these factors did not affect patients' performance or implantation in subsequent FET cycles.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Yaping Jiang, Rui Jiang, Hui He, Xinling Ren, Qiong Yu, Lei Jin
Summary: Embryo development speed and morphology score are important factors in frozen-thawed embryo transfer (FET) outcomes. D5 embryos are generally preferred over D6 embryos, but there is some variation in clinical outcomes. This study found that AA/AB blastocysts showed similar pregnancy outcomes regardless of development day, while BA/BB/BC blastocysts had better outcomes on D5 than D6. Comparing BC embryos on D5 and BA/BB embryos on D6, no differences were observed in clinical pregnancy outcomes and neonatal outcomes, but D6 BA/BB embryos had a higher miscarriage rate, which was not statistically significant after adjusting for confounding factors.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Ze-Han Dong, Ting Wu, Chen Zhang, Kai-Zhen Su, Yan-Ting Wu, He-Feng Huang
Summary: This study aimed to investigate the metabolic profile of children conceived through frozen and thawed embryo transfer (FET) in their early childhood. The results showed that children conceived through FET had lower levels of fasting insulin and HORM-IR, and higher levels of fasting glucose and APOE compared to naturally conceived children. Metabolomics analysis revealed 16 small differential metabolites, mainly including amino acids, carnitines, organic acids, butyric, and secondary bile acid, between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Mengxia Ji, Ling Zhang, Xiaohua Fu, Wenjie Xie, Xiangli Wu, Jing Shu
Summary: In patients with RIF, sequential embryo transfer did not improve clinical outcomes, and there were no significant differences in clinical pregnancy and ongoing pregnancy rates among the three groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Rui Chen, Ni Tang, Hongzi Du, Yaxin Yao, Yangyun Zou, Jing Wang, Dunmei Zhao, Xueliang Zhou, Yang Luo, Lei Li, Yuling Mao
Summary: The study aimed to explore the clinical application of noninvasive chromosomal screening (NICS) in elective single-blastocyst transfer (eSBT) in frozen-thawed cycles. The results showed that NICS combined with morphological assessment is an effective tool to guide frozen-thawed SBT.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Zhonghua Zhao, Yan Chen, Hongxia Deng, Lu Huang, Danhua Lu, Xiaoyang Shen, Liangzhi Xu
Summary: A systematic review and meta-analysis found that the stage of embryo transfer had a significant impact on obstetric and perinatal outcomes in programmed frozen-thawed embryo transfer (FET) and natural FET cycles. Programmed FET cycles had higher risks of hypertensive disorders of pregnancy, gestational hypertension, preeclampsia, gestational diabetes mellitus, large for gestational age, macrosomia, preterm delivery, placenta previa, postpartum haemorrhage, and preterm premature rupture of membranes compared to natural FET cycles with overall embryo transfer and blastocyst transfer. However, there were no clear differences in outcomes between programmed FET cycles and natural FET cycles with cleavage-stage embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jian-Chun Li, Yan-Hong Wang, Li-Ying Peng, Yun Zhou, Shi-Bin Chao
Summary: The DROI protocol showed significantly higher implantation rate and clinical pregnancy rate compared to the mNC protocol in frozen-thawed embryo transfer, suggesting it may be a more efficient and promising approach for improving pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Obstetrics & Gynecology
Regine P. M. Steegers-Theunissen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Health Care Sciences & Services
Batoul Hojeij, Sam Schoenmakers, Sten Willemsen, Lenie van Rossem, Andras Dinnyes, Melek Rousian, Regine P. M. Steegers-Theunissen
Summary: This study investigates the effectiveness of the eHealth program Smarter Pregnancy on attitudes and practices towards fruit and vegetable intake and smoking in women attempting pregnancy through assisted reproductive technology (ART) or natural conception. The results show that the program can improve vegetable intake-related attitudes and practices in women undergoing ART treatment. However, there is no significant effect on fruit intake and smoking behavior.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Melissa van der Windt, Sofie Karolina Maria van Zundert, Sam Schoenmakers, Lenie van Rossem, Regine Patricia Maria Steegers-Theunissen
Summary: This study developed a digital health care platform that integrates personalized lifestyle care with medical care, aiming to improve health care for both patients and health care professionals. The study found that the platform was feasible and patients were satisfied with it.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Endocrinology & Metabolism
Batoul Hojeij, Melek Rousian, Kevin D. Sinclair, Andras Dinnyes, Regine P. M. Steegers-Theunissen, Sam Schoenmakers
Summary: Periconceptional maternal obesity is associated with adverse maternal and neonatal outcomes. Identifying biomarkers of pathways affected by maternal obesity can provide insights into pathophysiological mechanisms and identify individuals at risk of adverse clinical outcomes. This systematic review identified biomarkers in the endocrine, inflammatory, and one-carbon metabolic pathways influenced by maternal obesity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Obstetrics & Gynecology
Rosalieke E. Wiegel, A. H. Jan Danser, Linette van Duijn, Sten P. Willemsen, Joop S. E. Laven, Eric A. P. Steegers, Esther B. Baart, Regine P. M. Steegers-Theunissen
Summary: This study investigated whether circulating maternal prorenin could serve as a proxy for oocyte and preimplantation embryo development. The results showed that high circulating maternal prorenin concentrations were associated with a larger oocyte area, faster cleavage divisions, and increased chance of successful implantation.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
C. S. Pietersma, A. G. M. G. J. Mulders, S. P. Willemsen, N. Graafland, A. C. Altena, A. H. J. Koning, B. S. de Bakker, E. A. P. Steegers, R. P. M. Steegers-Theunissen, M. Rousian
Summary: This study suggests that there is a difference in embryonic morphological development between ongoing pregnancies and live pregnancies ending in a miscarriage. Miscarriages tend to have smaller embryos and slower heart rates. This finding is important in terms of estimating the likelihood of a pregnancy continuing and providing support for those at risk of recurrent pregnancy loss.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Rosalieke E. Wiegel, Eleonora Rubini, Melek Rousian, Sam Schoenmakers, Joop S. E. Laven, Sten P. Willemsen, Esther B. Baart, Regine P. M. Steegers-Theunissen
Summary: This study investigates the relationship between oocyte area and various factors related to embryo development, such as fertilization rate, embryo usage, and preimplantation embryo development. The results suggest that oocyte area can serve as a marker for optimal early embryo development.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Endocrinology & Metabolism
Eva S. S. van Marion, Esther B. B. Baart, Margarida Santos, Linette van Duijn, Evert J. P. van Santbrink, Regine P. M. Steegers-Theunissen, Joop S. E. Laven, Marinus J. C. Eijkemans
Summary: This study developed a time-lapse monitoring (TLM) prediction model to predict pregnancy chances after single- and double-embryo transfer. Model A based on clinic A data accurately predicted pregnancy in clinic B, while model B based on clinic B data had less accuracy in predicting pregnancy in clinic A. This approach has potential applications in embryo selection and decision making.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Wietske A. P. Bastiaansen, Stefan Klein, Anton H. J. Koning, Wiro J. Niessen, Regine P. M. Steegers-Theunissen, Melek Rousian
Summary: Based on the analysis of 2575 studies, this systematic review found that automatic and learning-based methods show great potential in early-pregnancy brain ultrasound analysis. To bring these methods into clinical practice, it is recommended that studies use routine clinical data depicting both normal and abnormal development, make their dataset and program source code publicly available, and be attentive to the influence of confounding factors.
Article
Obstetrics & Gynecology
D. Aoulad Fares, R. E. Wiegel, A. J. Eggink, J. B. J. van Meurs, S. P. Willemsen, A. H. J. Danser, R. P. M. Steegers-Theunissen
Summary: This study aimed to investigate the associations between maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation in the first trimester and telomere length (TL) in pregnancies conceived naturally and after IVF/ICSI. Renin, prorenin, and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA) in 145 pregnancies of the Rotterdam Periconception cohort. TL was measured using qPCR at 20 weeks GA. The results showed a significantly negative correlation between renin and TL, which was attenuated for prorenin and not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after IVF/ICSI compared to natural pregnancies.
Conclusion: The negative association between first-trimester maternal renin and maternal TL, as well as the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.
HYPERTENSION IN PREGNANCY
(2023)
Article
Oncology
Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Roeder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Raikkonen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Haberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Regine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sorensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melen, Gemma C. Sharp, Matt J. Silver, Faisal Rezwan, John W. Holloway
Summary: This study found significant associations between DNA methylation and birth season at birth and in childhood. The differential methylation regions (DMRs) identified were related to genes involved in tumorigenesis, psychiatric/neurological disorders, inflammation, and immunity. Furthermore, the associations between birth season and DNA methylation were influenced by birth latitude, particularly in higher latitude regions.
CLINICAL EPIGENETICS
(2023)
Article
Endocrinology & Metabolism
Kim van der Ham, Karlijn J. Stekelenburg, Yvonne V. Louwers, Wendy van Dorp, Marco W. J. Schreurs, Ronald van der Wal, Regine P. M. Steegers-Theunissen, Joop S. E. Laven
Summary: Women with PCOS do not have a higher prevalence of thyroid dysfunction or hyperprolactinemia compared to controls.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Sharissa M. Smith, Babette Bais, Hafez Ismaili M'hamdi, Maartje H. N. Schermer, Regine P. M. Steegers-Theunissen
Summary: Women with low socioeconomic status are at a high risk of adverse pregnancy outcomes due to multiple health-deteriorating factors. This study aims to improve the engagement of these women in preconception care using a mobile health app and nudging theory, and assess its feasibility.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Nursing
J. Scheele, S. M. Smith, R. J. Wahab, B. Bais, R. P. M. Steegers-Theunissen, R. Gaillard, H. W. Harmsen van der Vliet-torij
Summary: This study evaluated the current practice of preconception care in the Netherlands and the perceptions of birth care professionals regarding preconception care. The findings suggest that although birth care professionals acknowledge the importance of preconception care, there are variations in the implementation and identification of risk factors across different organizations. Furthermore, there is a low demand for preconception care among prospective parents.