Carbohydrate based meningococcal vaccines: past and present overview

A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

(2020) Jacopo Enotarpi et al.   Nature Communications

Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

(2020) Timm Fiebig et al.   Nature Communications

GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines

(2020) Francesca Micoli et al.   Vaccines

Development of meningococcal polysaccharide conjugate vaccine that can elicit long-lasting and strong cellular immune response with hepatitis B core antigen virus-like particles as a novel carrier protein

(2019) Lingling Xu et al.   VACCINE

Immunogenicity and safety of meningococcal group A, C, W and Y tetanus toxoid conjugate vaccine: review of clinical and real-world evidence

(2019) Jamie Findlow et al.   Future Microbiology

Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C

(2019) Juned Dalal et al.   VACCINE

The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology

(2019) Vega Masignani et al.   Frontiers in Immunology

Combined Chemical Synthesis and Tailored Enzymatic Elongation Provide Fully Synthetic and Conjugation-Ready Neisseria meningitidis Serogroup X Vaccine Antigens

(2018) Davide Oldrini et al.   ACS Chemical Biology

Protein Carriers for Glycoconjugate Vaccines: History, Selection Criteria, Characterization and New Trends

(2018) Francesca Micoli et al.   MOLECULES

Meningococcal C conjugate vaccine effectiveness before and during an outbreak of invasive meningococcal disease due to Neisseria meningitidis serogroup C/cc11, Tuscany, Italy

(2018) Patrizio Pezzotti et al.   VACCINE

Breadth of coverage against a panel of 110 invasive disease isolates, immunogenicity and safety for 2 and 3 doses of an investigational MenABCWY vaccine in US adolescents – Results from a randomized, controlled, observer-blind phase II study

(2018) Jo Anne Welsch et al.   VACCINE

Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production

(2017) Timm Fiebig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

(2017) Ray Borrow et al.   JOURNAL OF INFECTION

Impact of MenAfriVac in nine countries of the African meningitis belt, 2010–15: an analysis of surveillance data

(2017) Caroline L Trotter et al.   LANCET INFECTIOUS DISEASES

High-yield production of recombinant CRM197, a non-toxic mutant of diphtheria toxin, in the periplasm of Escherichia coli

(2017) Philippe Goffin et al.   Biotechnology Journal

Synthesis and immunochemical evaluation of a novel Neisseria meningitidis serogroup A tetrasaccharide and its conjugate

(2017) Kishore R. Harale et al.   Organic Chemistry Frontiers

Preclinical studies on new proteins as carrier for glycoconjugate vaccines

(2016) M. Tontini et al.   VACCINE

Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis

(2016) Guochao Liao et al.   ACS Central Science

An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate

(2016) Timm Fiebig et al.   npj Vaccines

Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines

(2015) Guochao Liao et al.   CHEMICAL COMMUNICATIONS

Neisseria meningitidis: pathogenesis and immunity

(2015) Mariagrazia Pizza et al.   CURRENT OPINION IN MICROBIOLOGY

Immunogenicity of meningococcal quadrivalent (serogroup A, C, W135 and Y) tetanus toxoid conjugate vaccine: Systematic review and meta-analysis

(2015) Paolo Pellegrino et al.   PHARMACOLOGICAL RESEARCH

A Synthetic Disaccharide Analogue from Neisseria meningitidis A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated

(2015) Silvia Fallarini et al.   ACS Infectious Diseases

Synthesis and immunological evaluation of protein conjugates ofNeisseria meningitidisX capsular polysaccharide fragments

(2014) Laura Morelli et al.   Beilstein Journal of Organic Chemistry

Investigating the immunodominance of carbohydrate antigens in a bivalent unimolecular glycoconjugate vaccine against serogroup A and C meningococcal disease

(2014) Roberto Adamo et al.   GLYCOCONJUGATE JOURNAL

Molecular Cloning and Functional Characterization of Components of the Capsule Biosynthesis Complex ofNeisseria meningitidisSerogroup A

(2014) Timm Fiebig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide

(2013) Qi Gao et al.   ACS Chemical Biology

Synthesis ofNeisseria meningitidisSerogroup W135 Capsular Oligosaccharides for Immunogenicity Comparison and Vaccine Development

(2013) Chia-Hung Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: A new perspective for vaccine development

(2013) T. Fiebig et al.   GLYCOBIOLOGY

Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugates

(2013) Pumtiwitt C. McCarthy et al.   GLYCOCONJUGATE JOURNAL

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X

(2013) F. Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of CRM197, diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines

(2013) M. Tontini et al.   VACCINE

Synthesis and preliminary biological evaluation of carba analogues from Neisseria meningitidis A capsular polysaccharide

(2012) Qi Gao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Relative stability of meningococcal serogroup A and X polysaccharides

(2012) F. Berti et al.   VACCINE

History of meningococcal vaccines and their serological correlates of protection

(2012) Caroline Vipond et al.   VACCINE

Development of a group A meningococcal conjugate vaccine,MenAfriVacTM

(2012) Carl Frasch et al.   Human Vaccines & Immunotherapeutics

Biochemical and biological characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: Use as a conjugation protein in vaccines and other potential clinical applications

(2011) Michael Bröker et al.   BIOLOGICALS

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

Highly Alpha-Selective Sialyl Phosphate Donors for Efficient Preparation of Natural Sialosides

(2010) Che-Hsiung Hsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Effect of human serum on de-N-acetyl sialic acid epitope expression and antibody activity against N. meningitidis group B

(2010) Becca A. Flitter et al.   VACCINE

Vaccine development against Neisseria meningitidis

(2010) Ulrich Vogel et al.   Microbial Biotechnology

Meningococcal vaccines and herd immunity: lessons learned from serogroup C conjugate vaccination programs

(2009) Caroline L Trotter et al.   Expert Review of Vaccines

Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002

(2009) A. M. Whitney et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Vaccines Containing de- N -Acetyl Sialic Acid Elicit Antibodies Protective against Neisseria meningitidis Groups B and C

(2009) Gregory R. Moe et al.   JOURNAL OF IMMUNOLOGY

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

(2009) Michael Bröker et al.   VACCINE

Meningococcal protein antigens and vaccines

(2009) Ian M. Feavers et al.   VACCINE

Global epidemiology of meningococcal disease

(2009) Lee H. Harrison et al.   VACCINE

A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial

(2008) D Pace et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE

Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa

(2008) Che-Hung Lee et al.   VACCINE