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trans-Acting Factors and cis Elements Involved in the Human Inactive X Chromosome Organization and Compaction

GENETICS RESEARCH (2021)

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GENETICS RESEARCH

卷 2021, 期 -, 页码 -

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HINDAWI LTD

DOI: 10.1155/2021/6683460

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Genetics & Heredity

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Xi'an Medical University [2020DOC14, 2020DOC17]
Natural Science Basic Research Plan in Shaanxi Province of China [2021JQ-776, 2021JQ-774]

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摘要

During X chromosome inactivation, various chromatin changes occur, such as acquisition of repressive covalent histone modifications, associations with heterochromatin proteins, and DNA methylation of promoters. Trans-acting factors and cis elements involved in human inactive X chromosome organization and compaction have been summarized in this study.

During X chromosome inactivation, many chromatin changes occur on the future inactive X chromosome, including acquisition of a variety of repressive covalent histone modifications, heterochromatin protein associations, and DNA methylation of promoters. Here, we summarize trans-acting factors and cis elements that have been shown to be involved in the human inactive X chromosome organization and compaction.

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