Review
Gastroenterology & Hepatology
Babu P. Mohan, Deepak Madhu, Shahab R. Khan, Lena L. Kassab, Suresh Ponnada, Saurabh Chandan, Antonio Facciorusso, Stefano F. Crino, Luca Barresi, Stephanie McDonough, Douglas G. Adler
Summary: The study demonstrates that intracystic glucose levels in fluid samples collected by endoscopic ultrasound guided fine-needle aspiration can accurately differentiate mucinous pancreatic cysts from nonmucinous cysts, with a cut-off of 50mg/dL showing the best performance.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Imadh Khan, Muhammad Baig, Thrisha Bandepalle, Srinivas R. Puli
Summary: The meta-analysis suggests that cyst fluid CEA level at a cutoff of 192 ng/mL is highly specific in diagnosing mucinous cystic lesions with reasonable sensitivity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Efrat Zamir, Dana Zelnik Yovel, Erez Scapa, Mati Shnell, Nir Bar, Iddo Bar Yishay, Tomer Ziv-Baran, Fadi Younis, Adam Phillips, Nir Lubezky, Oren Shibolet, Dana Ben-Ami Shor
Summary: Glucose levels in pancreatic cystic fluid are more accurate than CEA for the diagnosis of mucinous cysts. Glucometry assessment of glucose levels shows excellent correlation with laboratory measurements and may serve as a useful diagnostic test.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Zachary L. Smith, Sagarika Satyavada, Roberto Simons-Linares, Shaffer R. S. Mok, Belen Martinez Moreno, Jose Ramon Aparicio, Prabhleen Chahal
Summary: This study compared the performance of glucose and CEA concentrations in differentiating MNPC. The results showed that intracystic glucose concentration is superior to CEA concentration, and glucose has the advantages of low cost and ease of implementation.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Sandra Faias, Marilia Cravo, Paula Chaves, Luisa Pereira
Summary: Glucose level in pancreatic cystic fluid performs better than carcinoembryonic antigen (CEA) for accurately diagnosing mucinous cysts, with higher sensitivity and fewer false-negative results. Glucose could potentially become a useful first-line test to exclude mucinous cysts, especially in small cysts with limited fluid volume. Larger studies are needed to confirm glucose as the preferred test for mucinous cyst diagnosis.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Myrte Gorris, Frederike Dijk, Arantza Farina, Johannes B. Halfwerk, Gerrit K. Hooijer, Selma J. Lekkerkerker, Rogier P. Voermans, Mattheus C. Wielenga, Marc G. Besselink, Jeanin E. van Hooft
Summary: This study assessed the value of combined CEA and glucose testing in pancreatic cyst fluid, and found that this method has high specificity and sensitivity for differentiating mucinous from non-mucinous pancreatic cystic neoplasms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nika Elmi, David Mcevoy, Matthew D. F. Mcinnes, Mostafa Alabousi, Elizabeth M. Hecht, Lyndon Luk, Sunna Asghar, Ankush Jajodia, Tiago Lins de Carvalho, William J. Warnica, Nanxi Zha, Sadaf Ullah, Christian B. van Der Pol
Summary: A low percentage of patients with pancreatic cystic lesions on MRI develop pancreatic adenocarcinoma. The first MRI revealing a cystic lesion should be monitored for the possibility of adenocarcinoma.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Gastroenterology & Hepatology
Tawfik Khoury, Rodica Gincul, Ismael Mohammedi, Wisam Sbeit, Bertrand Napoleon
Summary: The use of antibiotics for prophylaxis in pancreatic cystic lesions is still a debated topic. Current research lacks in quantity and has a small sample size, leading to biased results. Pooled data analysis shows that antibiotic prophylaxis does not have a significant impact on the rate of cyst infection. Larger international studies are needed to resolve this controversy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Michael Johannes Pflueger, Kevin Tony Jamouss, Elham Afghani, Su Jin Lim, Salvador Rodriguez Franco, Harrison Mayo, Marcus Spann, Hao Wang, Aatur Singhi, Anne Marie Lennon, Laura D. Wood
Summary: Analysis of cyst fluid biomarkers showed that mutations in KRAS and/or GNAS can efficiently identify mucinous cysts, while mutations in VHL are specific for serous cystadenomas. DNA-based cyst fluid biomarkers are crucial for accurately distinguishing pancreatic cyst types.
Review
Medicine, General & Internal
Ronald C. Turner, Jared T. Melnychuk, Wei Chen, Daniel Jones, Somashekar G. Krishna
Summary: Early detection and diagnosis of precursor lesions for pancreatic malignancy is crucial. Current diagnostic tools for cystic precursor lesions, such as CEA levels and cytology, have limitations. Molecular analysis of cystic fluid can improve the diagnosis and risk stratification of pancreatic malignancy precursor lesions.
Article
Medicine, General & Internal
Yohei Shirakami, Takuji Iwashita, Shinya Uemura, Hisashi Imai, Katsutoshi Murase, Masahito Shimizu
Summary: This study investigated the use of miRNA in pancreatic cyst fluid as a marker for evaluating malignant alternation of IPMN. Six miRNAs were found to be significantly enriched in IPMC compared to IPMA. Further evaluation with larger cohorts is needed to confirm the efficacy of cyst fluid miRNA analysis for diagnosing malignant alteration of IPMN.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Newton A. C. S. Wong, Muhammad Abdalkoddus, Nadeem Al-Khafaji, Huw Roach, Reyad Abbadi
Summary: This article aims to confirm whether simple biliary cysts of the liver can be lined by mucinous epithelium and assess whether the presence of mucinous epithelium is associated with hepatobiliary neoplasia. The study found that at least one-third of surgically-managed simple biliary cysts of the liver had focal mucinous epithelium. Apart from the presence of ovarian-like stroma, mucinous epithelium appears to have no clinical significance.
Review
Clinical Neurology
Yu-bo Wang, Dan -hua Wang, Shuang-lin Deng
Summary: This paper conducted a systematic review of secondary spinal arachnoid cysts and found that they have diverse etiologies and are difficult to treat. Although fenestration/marsupialization is a common treatment method, the recurrence rate is high. For unresectable cysts, shunting into a body cavity (such as the pleural or peritoneal cavity) may be an alternative therapy.
Review
Gastroenterology & Hepatology
Tommaso Pollini, Volcan Adsay, Gabriele Capurso, Marco Dal Molin, Irene Esposito, Ralph Hruban, Claudio Luchini, Laura Maggino, Hanno Matthaei, Giovanni Marchegiani, Aldo Scarpa, Laura D. Wood, Claudio Bassi, Roberto Salvia, Mari Mino-Kenudson, Ajay V. Maker
Summary: Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are precursors of invasive pancreatic ductal adenocarcinoma and their progression is influenced by the immune system. The immune composition of IPMNs changes during neoplastic progression, with low-grade lesions having a high proportion of effector T cells, while high-grade IPMNs and IPMNs with invasive carcinoma are characterized by a predominance of immunosuppressive elements.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adam M. Awe, Michael M. Vanden Heuvel, Tianyuan Yuan, Victoria R. Rendell, Mingren Shen, Agrima Kampani, Shanchao Liang, Dane D. Morgan, Emily R. Winslow, Meghan G. Lubner
Summary: The study aimed to develop and evaluate machine learning algorithms to distinguish mucinous from non-mucinous pancreatic cysts using radiomics. A mucinous phenotype classifier was successfully created using texture features, but model performance did not significantly improve compared to the combined model. SHAP analysis identified specific predictive features in the models.
ABDOMINAL RADIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Thomas R. McCarty, Christopher C. Thompson
Summary: Endoscopic bariatric and metabolic treatments (EBMTs) have been developed to combat the increasing prevalence of obesity, with FDA-approved and non-approved treatments available, including various devices and procedures such as intragastric balloons, aspiration therapy, and endoscopically placed anastomosis devices.
DIGESTIVE ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Thomas R. McCarty, Rishabh Gulati, Tarun Rustagi
Summary: The study demonstrated that peroral cholangioscopy with intraductal lithotripsy is a relatively safe and effective modality for difficult biliary stones. The overall stone fragmentation success rate was high, with laser lithotripsy showing advantages in single-session fragmentation rate and procedure time compared to electrohydraulic lithotripsy.
Article
Immunology
Thomas R. McCarty, Kelly E. Hathorn, Walker D. Redd, Nicolette J. Rodriguez, Joyce C. Zhou, Ahmad Najdat Bazarbashi, Cheikh Njie, Danny Wong, Quoc-Dien Trinh, Lin Shen, Valerie E. Stone, Walter W. Chan
Summary: This study aimed to characterize COVID-19-associated morbidity and in-hospital mortality by race/ethnicity through patient-level observations. The analysis of data from 9 Massachusetts hospitals did not find any significant association between race/ethnicity and clinically relevant hospitalization outcomes for COVID-19 patients, refuting suggestions of biological predisposition to poorer COVID-19 outcomes among certain races/ethnicities.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Gastroenterology & Hepatology
Thomas R. McCarty, Ahmad Najdat Bazarbashi, Christopher C. Thompson, Hiroyuki Aihara
Summary: Hybrid endoscopic submucosal dissection (ESD) is safe and effective for removal of colorectal lesions, with shorter procedure duration, fewer complications, and no significant difference in recurrence and surgery rates compared to conventional ESD; however, it has a lower en bloc resection rate.
Article
Surgery
Fouad Chouairi, Thomas R. McCarty, Kelly E. Hathorn, Prabin Sharma, Harry R. Aslanian, Priya A. Jamidar, Christopher C. Thompson, Thiruvengadam Muniraj
Summary: The study found that immediate cholecystectomy after ERCP for acute gallstone pancreatitis can significantly reduce mortality, but clinical practice remains inconsistent. Factors such as female gender, Black race, higher CCI, Medicare payer status, urban-teaching hospital location, and higher household income reduce the likelihood of patients undergoing same admission CCY + ERCP.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Sanchit Gupta, Jinyi Zhu, Thomas R. McCarty, Jordan Pruce, Zain Kassam, Colleen Kelly, Monika Fischer, Jessica R. Allegretti
Summary: The study shows that the sequential fecal microbiota transplantation (sFMT) protocol for Fulminant Clostridioides difficile infections (FCDI) is cost-effective, leading to lower overall costs and higher Quality-Adjusted Life Years (QALY) compared to standard therapy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Thomas R. McCarty, Fouad Chouairi, Kelly E. Hathorn, Prabin Sharma, Thiruvengadam Muniraj, Christopher C. Thompson
Summary: The study found that in the treatment of acute cholecystitis, patients receiving PC were mostly in urban teaching hospitals, with longer lengths of stay, higher hospital costs, and higher mortality rates. Multiple socioeconomic and healthcare related factors influence the utilization of PC, including gender, race/ethnicity, payer status, hospital location, and household income.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Editorial Material
Gastroenterology & Hepatology
Guilherme Henrique Peixoto de Oliveira, Diogo Turiani Hourneaux de Moura, Thomas R. McCarty, Pedro Victor Aniz Gomes de Oliveira, Mateus Pereira Funari, Spencer Cheng, Eduardo Guimaraes Hourneaux de Moura
Editorial Material
Gastroenterology & Hepatology
Diogo Turiani Hourneaux de Moura, Joao Remi de Freitas Junior, Gabriel Mayo Vieira de Souza, Guilherme Henrique Peixoto de Oliveira, Thomas R. McCarty, Christopher C. Thompson, Eduardo Guimaraes Hourneaux de Moura
Review
Surgery
Mateus Bond Boghossian, Mateus Pereira Funari, Diogo Turiani Hourneaux De Moura, Thomas R. McCarty, Vitor Massaro Takamatsu Sagae, Yen- Chen, Pastor Joaquin Ortiz Mendieta, Fernando Lopes Ponte Neto, Wanderley Marques Bernardo, Marcos Eduardo Lera dos Santos, Filipe Tomishige Chaves, Mouen A. Khashab, Eduardo Guimaraes Hourneaux de Moura
Summary: EUS-GE was associated with significantly improved outcomes compared to DS placement for palliative treatment of malignant GOO. Despite SGJ possessing a higher technical success compared to EUS-GE, LOS was significantly longer with no difference in clinical success or rate of adverse events.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Gastroenterology & Hepatology
Marina Tucci Gammaro Baldavira Ferreira, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Thomas R. McCarty, Alberto Machado da Ponte Neto, Galileu Ferreira Ayala Farias, Antonio Afonso de Miranda Neto, Pedro Victor Aniz Gomes de Oliveira, Wanderley Marques Bernardo, Eduardo Guimaraes Hourneaux de Moura
Summary: Compared to balloon dilation, stent placement for dominant strictures in PSC appeared to have higher complication rates without significant differences in efficacy.
CLINICAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Diogo Turiani Hourneaux de Moura, Bruno Salomao Hirsch, Thomas R. McCarty, Marcos Eduardo dos Santos, Hugo Goncalo Guedes, Guilherme Francisco Gomes, Flaubert Sena de Medeiros, Eduardo Guimaraes Hourneaux de Moura
Summary: This study evaluated the efficacy and safety of a novel homemade endoscopic vacuum therapy for the treatment of transmural gastrointestinal defects. A total of 144 patients were included, with a technical success rate of 100% and a clinical success rate of 88.89%. The use of this homemade EVT was found to be feasible, safe, and effective for the management of TGID.
DIGESTIVE ENDOSCOPY
(2023)
Letter
Gastroenterology & Hepatology
Basile Njei, Thomas R. McCarty, Udayakumar Navaneethan
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Basile Njei, Ulrick Sidney Kanmounye, Nancy Seto, Thomas. R. R. McCarty, Babu. P. P. Mohan, Lydia Fozo, Udayakumar Navaneethan
Summary: This study provides a comprehensive overview of the application of artificial intelligence (AI) in medical imaging for cholangiocarcinoma (CCA) diagnosis. The results showed that China and the United States had the highest number of publications, and convolutional neural networks (CNN) were the most commonly used classifiers. CNN-cholangioscopy demonstrated the highest performance for diagnosing extrahepatic CCA. The analysis also revealed an Asian and American predominance in the research network of AI in CCA diagnosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)