Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Clinical approach to the inflammatory etiology of cardiovascular diseases

(2020) Massimiliano Ruscica et al.   PHARMACOLOGICAL RESEARCH

Role of spices in the treatment of diabetes mellitus: A minireview

(2020) Nevin Sanlier et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical

(2020) Ruheea Taskin Ruhee et al.   Antioxidants

Piperine: A review of its biological effects

(2020) Iahtisham‐Ul Haq et al.   PHYTOTHERAPY RESEARCH

Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil

(2020) Chi Zhang et al.   FOOD CHEMISTRY

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

(2019) Toshitaka Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anemia of Inflammation

(2019) Tomas Ganz   NEW ENGLAND JOURNAL OF MEDICINE

The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesis

(2019) Lisong Hu et al.   Nature Communications

Hepcidin and Anemia: A Tight Relationship

(2019) Alessia Pagani et al.   Frontiers in Physiology

Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey

(2018) Andreas M Hohlbaum et al.   BRITISH JOURNAL OF PHARMACOLOGY

Grid Based Technologies for in silico Screening and Drug Design

(2018) Vladimir Potemkin et al.   CURRENT MEDICINAL CHEMISTRY

Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues

(2018) Marija Lesjak et al.   EUROPEAN JOURNAL OF NUTRITION

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

(2018) Nicholas Thomford et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mTOR-mediated lipophagy

(2018) Ritu Varshney et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anemia of inflammation

(2018) Guenter Weiss et al.   BLOOD

Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation

(2018) Mukul Jain et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway

(2017) Stanzin Angmo et al.   Scientific Reports

Diet, Nutrition, and Cancer Epigenetics

(2016) Carmen Sapienza et al.   Annual Review of Nutrition

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Piperine Plays an Anti-Inflammatory Role inStaphylococcus aureusEndometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice

(2016) Wen-jun Zhai et al.   Evidence-based Complementary and Alternative Medicine

The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression

(2016) Mingdao Mu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Energetics, Thermodynamics, and Molecular Recognition of Piperine with DNA

(2015) P. Haris et al.   Journal of Chemical Information and Modeling

Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity

(2015) Tiancen Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways

(2015) Carolyn D. Doucette et al.   TOXICOLOGY LETTERS

Black soyabean seed coat extract regulates iron metabolism by inhibiting the expression of hepcidin

(2014) Mingdao Mu et al.   BRITISH JOURNAL OF NUTRITION

Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway

(2014) Yuhan Tang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

A systematic analysis of global anemia burden from 1990 to 2010

(2013) N. J. Kassebaum et al.   BLOOD

Suppression of Iron-Regulatory Hepcidin by Vitamin D

(2013) J. Bacchetta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Piper nigrumand Piperine: An Update

(2013) Murlidhar Meghwal et al.   PHYTOTHERAPY RESEARCH

Anemia of Chronic Disease

(2013) Naseema Gangat et al.   SEMINARS IN HEMATOLOGY

Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients

(2013) Soken-Nakazawa J Song et al.   ARTHRITIS RESEARCH & THERAPY

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quinolizidine alkaloid biosynthesis: recent advances and future prospects

(2012) Somnuk Bunsupa et al.   Frontiers in Plant Science

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

(2010) M. Poli et al.   BLOOD

Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

(2010) S.-N. J. Song et al.   BLOOD

Interacting signals in the control of hepcidin expression

(2009) Deepak Darshan et al.   BIOMETALS

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

STAT3 signaling within hepatocytes is required for anemia of inflammation in vivo

(2009) Ryotaro Sakamori et al.   JOURNAL OF GASTROENTEROLOGY

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE