Current advances of endophytes as a platform for production of anti-cancer drug camptothecin

Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

(2021) Amit Rai et al.   Nature Communications

Sustainable production of camptothecin from an Alternaria sp. isolated from Nothapodytes nimmoniana

(2021) I. A. H. Khwajah Mohinudeen et al.   Scientific Reports

The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila

(2021) Xiaolong Hao et al.   Horticulture Research

Heterologous overexpression of Nothapodytes foetida strictosidine synthase enhances levels of anti-cancer compound camptothecin in Ophiorrhiza rugosa

(2020) Sudhir Singh et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Plant Endophytes and Epiphytes: Burgeoning Sources of Known and “Unknown” Cytotoxic and Antibiotic Agents?

(2020) David J. Newman et al.   PLANTA MEDICA

Ultrasonic-assisted extraction of polyphenols and antioxidants from Picea abies bark

(2020) Daniela Chmelová et al.   JOURNAL OF BIOTECHNOLOGY

Conventional and nonconventional extraction techniques for optimal extraction processes of rosmarinic acid from six Lamiaceae plants as determined by HPLC-DAD measurement

(2020) Beatrix Sik et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

WRKY transcription factor OpWRKY1 acts as a negative regulator of camptothecin biosynthesis in Ophiorrhiza pumila hairy roots

(2020) Man Xu et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Nanoelicitor based enhancement of camptothecin production in fungi isolated from Ophiorrhiza mungos

(2020) Ravi Aswani et al.   BIOTECHNOLOGY PROGRESS

High Doses of Δ9-Tetrahydrocannabinol Might Impair Irinotecan Chemotherapy: A Review of Potentially Harmful Interactions

(2020) Nevenka Kopjar et al.   CLINICAL DRUG INVESTIGATION

Sacituzumab Govitecan: First Approval

(2020) Yahiya Y. Syed   DRUGS

Targeted metabolic engineering of committed steps improves anti-cancer drug camptothecin production in Ophiorrhiza pumila hairy roots

(2020) Min Shi et al.   INDUSTRIAL CROPS AND PRODUCTS

Enhanced AmB Production in Streptomyces nodosus by Fermentation Regulation and Rational Combined Feeding Strategy

(2020) Bo Zhang et al.   Frontiers in Bioengineering and Biotechnology

Natural Product as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases

(2020) Swati Singh et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications

(2020) Madira Coutlyne Manganyi et al.   Microorganisms

Enhanced Liver Targeting of Camptothecin via Conjugation with Deoxycholic Acid

(2019) Linxia Xiao et al.   MOLECULES

Microwave-Assisted Extraction of Multiple Trace Levels of Intermediate Metabolites for Camptothecin Biosynthesis in Camptotheca acuminata and Their Simultaneous Determination by HPLC-LTQ-Orbitrap-MS/MS and HPLC-TSQ-MS

(2019) Zhaoxia Jin et al.   MOLECULES

Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis

(2019) Yun Yang et al.   ACS Chemical Biology

Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants

(2019) Xiang Pu et al.   FITOTERAPIA

Camptothecin induces c-Myc- and Sp1-mediated hTERT expression in LNCaP cells: Involvement of reactive oxygen species and PI3K/Akt

(2019) Matharage Gayani Dilshara et al.   FOOD AND CHEMICAL TOXICOLOGY

Camptothecin induces mitotic arrest through Mad2-Cdc20 complex by activating the JNK-mediated Sp1 pathway

(2019) Matharage Gayani Dilshara et al.   FOOD AND CHEMICAL TOXICOLOGY

Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan

(2019) David M. Goldenberg et al.   mAbs

Transcription Factor OpWRKY3 Is Involved in the Development and Biosynthesis of Camptothecin and Its Precursors in Ophiorrhiza pumila Hairy Roots

(2019) Can Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A comparative study between conventional and non-conventional extraction techniques for the recovery of ergosterol from Agaricus blazei Murrill

(2019) Oludemi Taofiq et al.   FOOD RESEARCH INTERNATIONAL

Effects of camptothecin on the rice blast fungus Magnaporthe oryzae

(2019) Shu Xu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Improved 18S and 28S rDNA primer sets for NGS-based parasite detection

(2019) Asuka Kounosu et al.   Scientific Reports

A review on camptothecin analogs with promising cytotoxic profile

(2018) Sk. Abdul Amin et al.   Anti-Cancer Agents in Medicinal Chemistry

The improvement of bioactive secondary metabolites accumulation in Rumex gmelini Turcz through co-culture with endophytic fungi

(2018) Chang-hong Ding et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Pharmacokinetic and pharmacogenetic markers of irinotecan toxicity

(2018) Roberta Zilles Hahn et al.   CURRENT MEDICINAL CHEMISTRY

Development of novel techniques to extract phenolic compounds from Romanian cultivars of Prunus domestica L. and their biological properties

(2018) Andrei Mocan et al.   FOOD AND CHEMICAL TOXICOLOGY

Camptothecin induces G2/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species

(2018) Rajapaksha Gedara Prasad Tharanga Jayaso et al.   Oncotarget

Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review

(2018) Fazilath Uzma et al.   Frontiers in Pharmacology

Bioreactor studies of production of mycophenolic acid by Penicillium brevicompactum

(2018) Gopal Patel et al.   BIOCHEMICAL ENGINEERING JOURNAL

Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo

(2018) Hongzhi Du et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK

(2018) Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.   FOOD AND CHEMICAL TOXICOLOGY

Elicitors Derived from Hazel (Corylus avellana L.) Cell Suspension Culture Enhance Growth and Paclitaxel Production of Epicoccum nigrum

(2018) Mina Salehi et al.   Scientific Reports

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Selected commercial plants: A review of extraction and isolation of bioactive compounds and their pharmacological market value

(2018) Jayanta Kumar Patra et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Camptothecin-producing endophytic bacteria from Pyrenacantha volubilis Hook. (Icacinaceae): A possible role of a plasmid in the production of camptothecin

(2017) K.N. Soujanya et al.   PHYTOMEDICINE

De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb.

(2017) Gulzar A. Rather et al.   PLANT MOLECULAR BIOLOGY

Production of Mycophenolic Acid by Penicillium brevicompactum Using Solid State Fermentation

(2016) Gopal Patel et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Effect of fermentation parameters, elicitors and precursors on camptothecin production from the endophyte Fusarium solani

(2016) Aarthi Venugopalan et al.   BIORESOURCE TECHNOLOGY

Camptothecine production by mixed fermentation of two endophytic fungi from Nothapodytes nimmoniana

(2016) Bhumika N. Bhalkar et al.   Fungal Biology

Transcriptome analysis of stem wood of Nothapodytes nimmoniana (Graham) Mabb. identifies genes associated with biosynthesis of camptothecin, an anti-carcinogenic molecule

(2016) B L Manjunatha et al.   JOURNAL OF BIOSCIENCES

An MYB transcription factor regulating specialized metabolisms in Ophiorrhiza pumila

(2016) Emelda Rosseleena Rohani et al.   Plant Biotechnology

Function of AP2/ERF Transcription Factors Involved in the Regulation of Specialized Metabolism in Ophiorrhiza pumila Revealed by Transcriptomics and Metabolomics

(2016) Nirin Udomsom et al.   Frontiers in Plant Science

Fluorescence Spectroscopy in Camptothecins Studies

(2016) S. Kruszewski et al.   ACTA PHYSICA POLONICA A

Enhanced camptothecin production by ethanol addition in the suspension culture of the endophyte, Fusarium solani

(2015) Aarthi Venugopalan et al.   BIORESOURCE TECHNOLOGY

Plants and endophytes: equal partners in secondary metabolite production?

(2015) Jutta Ludwig-Müller   BIOTECHNOLOGY LETTERS

Restoration of camptothecine production in attenuated endophytic fungus on re-inoculation into host plant and treatment with DNA methyltransferase inhibitor

(2015) M. M. Vasanthakumari et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Production of camptothecine using whey by an endophytic fungus: standardization using response surface methodology

(2015) Bhumika N. Bhalkar et al.   RSC Advances

Pyrenacantha volubilis Wight, (Icacinaceae) a rich source of camptothecine and its derivatives, from the Coromandel Coast forests of India

(2014) Hirenallur Kumarappa Suma et al.   FITOTERAPIA

Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-d-xylulose 5-phosphate reductoisomerase

(2014) Min Shi et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Optimization and Kinetic Modeling of Cell-Associated Camptothecin Production from an EndophyticFusarium oxysporumNFX06

(2014) Sogra Fathima Musavi et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production

(2013) Xiang Pu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effect of precursors feeding and media manipulation on production of novel anticancer pro-drug camptothecin from endophytic fungus

(2013) Touseef Amna et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Isolation of endophytic bacteria producing the anti-cancer alkaloid camptothecine from Miquelia dentata Bedd. (Icacinaceae)

(2013) S. Shweta et al.   PHYTOMEDICINE

New plant sources of the anti-cancer alkaloid, camptothecine from the Icacinaceae taxa, India

(2013) B.T. Ramesha et al.   PHYTOMEDICINE

Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20

(2012) Bing Liu et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila

(2012) Takashi Asano et al.   PHYTOCHEMISTRY

An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin

(2011) S. Rehman et al.   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

Plant-Derived Bioactive Compounds Produced by Endophytic Fungi

(2011) J. Zhao et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata

(2010) Kaihui Liu et al.   BIOTECHNOLOGY LETTERS

Fermentative production of self-toxic fungal secondary metabolites

(2009) Maya P. Singh et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Combination of Microwave Assisted Micellar Extraction and Liquid Chromatography for Determination of Cryptotanshinone, Tanshinone I, and Tanshinone IIA inSalvia MiltiorrhizaBunge

(2009) Zhihong Shi et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

Comparative studies and identification of camptothecin produced by an endophyte at shake flask and bioreactor

(2009) Suriya Rehman et al.   NATURAL PRODUCT RESEARCH

Endophytic fungal strains of Fusarium solani, from Apodytes dimidiata E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin

(2009) S. Shweta et al.   PHYTOCHEMISTRY