A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present)

The Serine/Threonine Kinase AP2-Associated Kinase 1 Plays an Important Role in Rabies Virus Entry

(2020) Chong Wang et al.   Viruses-Basel

Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients

(2020) Justin Stebbing et al.   EMBO Molecular Medicine

Rhabdovirus Infection Is Dependent on Serine/Threonine Kinase AP2-Associated Kinase 1

(2020) Jun Luo et al.   Life-Basel

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

(2019) Megan J. Agajanian et al.   Cell Reports

Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

(2019) Sven Verdonck et al.   JOURNAL OF MEDICINAL CHEMISTRY

SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K

(2019) Carrow Wells et al.   ACS Medicinal Chemistry Letters

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

(2018) Szu-Yuan Pu et al.   ANTIVIRAL RESEARCH

Periodic Variation of AAK1 in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease

(2018) Xue Fu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release

(2018) Fei Xiao et al.   mBio

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

[ 3 H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement

(2017) Justin V. Louis et al.   NEUROPHARMACOLOGY

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

(2016) Fiona J. Sorrell et al.   STRUCTURE

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Comprehensive characterization of the Published Kinase Inhibitor Set

(2015) Jonathan M Elkins et al.   NATURE BIOTECHNOLOGY

Dysfunction of Endocytic Kinase AAK1 in ALS

(2014) Bingxing Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clathrin Potentiates Vaccinia-Induced Actin Polymerization to Facilitate Viral Spread

(2012) Ashley C. Humphries et al.   Cell Host & Microbe

Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis

(2012) H.-C. Huang et al.   JOURNAL OF VIROLOGY

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

(2012) Gregory Neveu et al.   PLoS Pathogens

AAK1 Identified as an Inhibitor of Neuregulin-1/ErbB4-Dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics

(2011) Letian Kuai et al.   CHEMISTRY & BIOLOGY

The Adaptor-associated Kinase 1, AAK1, Is a Positive Regulator of the Notch Pathway

(2011) Neetu Gupta-Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential requirements for clathrin endocytic pathway components in cellular entry by Ebola and Marburg glycoprotein pseudovirions

(2011) Suchita Bhattacharyya et al.   VIROLOGY

Genomewide association study for onset age in Parkinson disease

(2009) Jeanne C Latourelle et al.   BMC Medical Genetics

AAK1 Regulates Numb Function at an Early Step in Clathrin-Mediated Endocytosis

(2008) Erika B. Sorensen et al.   TRAFFIC