Synthesis of Alkyl Fluorides by Silver‐Catalyzed Radical Decarboxylative Fluorination of Cesium Oxalates

Deoxyfluorination using CuF2 enabled by a Lewis base activating group strategy

(2020) Deepali Eilidh Sood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Selective Photochemical Fluorination of Ketals: Unanticipated Outcomes in Selectivity and Stability

(2020) Joseph N. Capilato et al.   JOURNAL OF ORGANIC CHEMISTRY

δ-C–H Mono- and Dihalogenation of Alcohols

(2020) Alastair N. Herron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Reductive Vinylation of Tertiary Alkyl Oxalates with Activated Vinyl Halides

(2020) Yang Ye et al.   ORGANIC LETTERS

C(sp3)–H Fluorination with a Copper(II)/(III) Redox Couple

(2020) Jamey K. Bower et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Redox Neutral Radical-Relay Cobalt Catalysis toward C–H Fluorination and Amination

(2020) Peng Guo et al.   ORGANIC LETTERS

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Carbonyl-Directed Aliphatic Fluorination: A Special Type of Hydrogen Atom Transfer Beats Out Norrish II

(2020) Fereshte Ghorbani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dehydroxylative Fluorination of Tertiary Alcohols

(2020) Wei Zhang et al.   ORGANIC LETTERS

A Series of Deoxyfluorination Reagents Featuring OCF2 Functional Groups

(2020) Shiyu Zhao et al.   ORGANIC LETTERS

Synthesis of Reverse Glycosyl Fluorides and Rare Glycosyl Fluorides Enabled by Radical Decarboxylative Fluorination of Uronic Acids

(2020) Pengwei Chen et al.   ORGANIC LETTERS

Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes

(2019) Spencer P. Pitre et al.   ACS Catalysis

Experimental and Theoretical Evidence for Nitrogen–Fluorine Halogen Bonding in Silver-Initiated Radical Fluorinations

(2019) Alyssa M. Hua et al.   ACS Catalysis

Electrochemical C(sp3)–H Fluorination

(2019) Phil Baran et al.   SYNLETT

Ni-Catalyzed Reductive C–O Bond Arylation of Oxalates Derived from α-Hydroxy Esters with Aryl Halides

(2019) Mengyu Gao et al.   ORGANIC LETTERS

Room Temperature Deoxyfluorination of Benzaldehydes and α-Ketoesters with Sulfuryl Fluoride and Tetramethylammonium Fluoride

(2019) Patrick R. Melvin et al.   ORGANIC LETTERS

Ag-Catalyzed Chemoselective Decarboxylative Mono- and gem-Difluorination of Malonic Acid Derivatives

(2019) Zhen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Promoted Fe(III)-Catalyzed Hydrofluorination of Alkenes

(2019) Mengchun Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The fluorination of C-H bonds: developments and perspectives

(2019) Veronique Gouverneur et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deoxygenative Borylation of Secondary and Tertiary Alcohols

(2019) Florian Werner Friese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Deoxyfluorination of Alcohols with N ‐Tosyl‐4‐chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor) at Room Temperature

(2019) Junkai Guo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective, Intermolecular Alkylarylation of Alkenes via Photoredox/Nickel Dual Catalysis

(2019) Lei Guo et al.   ORGANIC LETTERS

Radical Functionalization of Unsaturated Amino Acids: Synthesis of Side-Chain-Fluorinated, Azido-Substituted, and Hydroxylated Amino Acids

(2019) Philip A. P. Reeve et al.   ACS Omega

Recent advances in transition-metal-catalyzed incorporation of fluorine-containing groups

(2019) Xiaowei Li et al.   Beilstein Journal of Organic Chemistry

Light‐mediated Formal Radical Deoxyfluorination of Tertiary Alcohols via Selective Single Electron Oxidation with TEDA2+·

(2019) Francisco José Aguilar Troyano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor®

(2019) María González-Esguevillas et al.   TETRAHEDRON

Silver-Catalyzed Decarboxylative Alkylfluorination of Alkenes

(2019) Chen-Guang Li et al.   ORGANIC LETTERS

Predictable site-selective radical fluorination of tertiary ethers

(2019) Junyang Ma et al.   Science China-Chemistry

Radical Dehydroxymethylative Fluorination of Carbohydrates and Divergent Transformations of the Resulting Reverse Glycosyl Fluorides

(2019) Xin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst‐Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro‐Induced Radical Formation

(2019) Xiaoping Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Open-Shell Fluorination of Alkyl Bromides: Unexpected Selectivity in a Silyl Radical-Mediated Chain Process

(2019) Gabrielle H. Lovett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzylic Fluorination of Aza-Heterocycles Induced by Single-Electron Transfer to Selectfluor

(2018) Kelley E. Danahy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amidyl Radicals by Oxidation of α-Amido-oxy Acids: Transition-Metal-Free Amidofluorination of Unactivated Alkenes

(2018) Heng Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fe(II)-Catalyzed Site-selective Functionalization of Unactivated C(sp3)-H Bonds Guided by Alkoxyl Radical

(2018) Lei Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

(2018) Yi Zhu et al.   CHEMICAL REVIEWS

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Catalyzed and Promoted Aliphatic Fluorination

(2018) Desta Doro Bume et al.   JOURNAL OF ORGANIC CHEMISTRY

Radical Carbofluorination of Unactivated Alkenes with Fluoride Ions

(2018) Zhonglin Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,6-Addition of Tertiary Carbon Radicals Generated From Alcohols or Carboxylic Acids by Visible-Light Photoredox Catalysis

(2018) Samir Y. Abbas et al.   ORGANIC LETTERS

Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group

(2018) Hiromichi Egami et al.   ORGANIC LETTERS

Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin

(2018) Wei Liu et al.   Chemical Science

Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

(2018) Sara P. Morcillo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the synthesis of functionalised monofluorinated compounds

(2018) Santos Fustero et al.   CHEMICAL COMMUNICATIONS

Visible-Light-Initiated, Photocatalyst-Free Decarboxylative Coupling of Carboxylic Acids with N-Heterocycles

(2018) Xiao-Yu Zhang et al.   ORGANIC LETTERS

Radical Deoxychlorination of Cesium Oxalates for the Synthesis of Alkyl Chlorides

(2018) Justin Y. Su et al.   ORGANIC LETTERS

Deconstructive fluorination of cyclic amines by carbon-carbon cleavage

(2018) Jose B. Roque et al.   SCIENCE

Catalytic formation of C(sp3)-F bonds via heterogeneous photocatalysis

(2018) Giulia Tarantino et al.   ACS Catalysis

Radical carbofluorination of alkenes with arylhydrazines and Selectfluor: Additives, mechanistic pathways and polar effects

(2018) Anna Pirzer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers

(2018) Yang Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One-pot synthesis of tertiary alkyl fluorides from methyl oxalates by radical deoxyfluorination under photoredox catalysis

(2018) Julien Brioche   TETRAHEDRON LETTERS

A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides

(2018) Daniel Meyer et al.   Nature Communications

syn-Selective alkylarylation of terminal alkynes via the combination of photoredox and nickel catalysis

(2018) Lei Guo et al.   Nature Communications

Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives

(2017) Qiao Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Hypervalent Iodine(III)-Mediated Decarboxylative Ritter-Type Amination Leading to the Production of α-Tertiary Amine Derivatives

(2017) Kensuke Kiyokawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Multiple Enone-Directed Reactivity Modes Lead to the Selective Photochemical Fluorination of Polycyclic Terpenoid Derivatives

(2017) Cody Ross Pitts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical fluorination reactions by thermal and photoinduced methods

(2017) Beatriz Lantaño et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Radical C–H Fluorination Using Unprotected Amino Acids as Radical Precursors

(2017) Alyssa M. Hua et al.   ORGANIC LETTERS

Ketones as directing groups in photocatalytic sp3 C–H fluorination

(2017) Desta Doro Bume et al.   Chemical Science

Silver-Catalyzed Anti-Markovnikov Hydroxyfluorination of Styrenes

(2017) Yan Li et al.   ACS Catalysis

Silver-catalyzed radical carbofluorination of unactivated alkenes with acetic acid in aqueous solution

(2017) He Chen et al.   Organic Chemistry Frontiers

Photoredox Activation of SF6for Fluorination

(2016) T. Andrew McTeague et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Transition-Metal-Free Decarboxylative Photoredox Coupling of Carboxylic Acids and Alcohols with Aromatic Nitriles

(2016) Benjamin Lipp et al.   JOURNAL OF ORGANIC CHEMISTRY

Aminofluorination of Cyclopropanes: A Multifold Approach through a Common, Catalytically Generated Intermediate

(2016) Cody Ross Pitts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alcohols as Latent Coupling Fragments for Metallaphotoredox Catalysis: sp3–sp2 Cross-Coupling of Oxalates with Aryl Halides

(2016) Xiaheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

O-Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O-Carboxydifluoromethylation and Decarboxylative Fluorination

(2016) Min Zhou et al.   ORGANIC LETTERS

Recent advances in radical-mediated fluorination through C–H and C–C bond cleavage

(2016) Hong Yan et al.   Science China-Chemistry

Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes

(2016) Lingchun Li et al.   Nature Communications

Insights into the mechanism of silver-catalyzed decarboxylative fluorination

(2016) Xiang Zhang   Computational and Theoretical Chemistry

Concise synthesis of cyclic carbonyl compounds from haloarenes using phenyl formate as the carbonyl source

(2015) Hideyuki Konishi et al.   CHEMICAL COMMUNICATIONS

Monofluorination of Organic Compounds: 10 Years of Innovation

(2015) Pier Alexandre Champagne et al.   CHEMICAL REVIEWS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment Coupling and the Construction of Quaternary Carbons Using Tertiary Radicals Generated From tert-Alkyl N-Phthalimidoyl Oxalates By Visible-Light Photocatalysis

(2015) Gregory L. Lackner et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Study of Silver-Catalyzed Decarboxylative Fluorination

(2015) Niki R. Patel et al.   JOURNAL OF ORGANIC CHEMISTRY

PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent

(2015) Matthew K. Nielsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling

(2015) Christopher C. Nawrat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Advances in Radical Fluorination

(2015) Jean-François Paquin et al.   SYNTHESIS-STUTTGART

Modern Carbon–Fluorine Bond Forming Reactions for Aryl Fluoride Synthesis

(2014) Michael G. Campbell et al.   CHEMICAL REVIEWS

Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions

(2014) Xiaoyu Yang et al.   CHEMICAL REVIEWS

Silver-Catalyzed Radical Fluorination of Alkylboronates in Aqueous Solution

(2014) Zhaodong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

(2013) Grégory Landelle et al.   Beilstein Journal of Organic Chemistry

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Late-Stage Deoxyfluorination of Alcohols with PhenoFluor

(2013) Filippo Sladojevich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Construction of Quaternary Carbons from Tertiary Alcohols via Photoredox-Catalyzed Fragmentation of tert-Alkyl N-Phthalimidoyl Oxalates

(2013) Gregory L. Lackner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine Transfer to Alkyl Radicals

(2012) Montserrat Rueda-Becerril et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Decarboxylative Fluorination of Aliphatic Carboxylic Acids in Aqueous Solution

(2012) Feng Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling†,‡

(2010) Alexandre L’Heureux et al.   JOURNAL OF ORGANIC CHEMISTRY

Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity

(2010) Teruo Umemoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbon-Fluorine Bond Formation for the Synthesis of Aryl Fluorides

(2010) Tobias Ritter et al.   SYNTHESIS-STUTTGART

Aminodifluorosulfinium Tetrafluoroborate Salts as Stable and Crystalline Deoxofluorinating Reagents

(2009) Francis Beaulieu et al.   ORGANIC LETTERS

Development of fluorination methods using continuous-flow microreactors

(2009) Marcus Baumann et al.   TETRAHEDRON

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

Fluorinated nucleosides: Synthesis and biological implication

(2008) Peng Liu et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS