Article
Biochemistry & Molecular Biology
Yi Lin, Noopur S. Raje, Jesus G. Berdeja, David S. Siegel, Sundar Jagannath, Deepu Madduri, Michaela Liedtke, Jacalyn Rosenblatt, Marcela V. Maus, Monica Massaro, Fabio Petrocca, Ashish Yeri, Olivia Finney, Andrea Caia, Zhihong Yang, Nathan Martin, Timothy B. Campbell, Julie Rytlewski, Jaymes Fuller, Kristen Hege, Nikhil C. Munshi, James N. Kochenderfer
Summary: This study conducted a post hoc analysis of the use of Idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma and found that it is safe and well-tolerated, with a positive impact on response rates. Additionally, the study identified a correlation between the state of T cells and durable responses.
Article
Gastroenterology & Hepatology
Delphine Salfati, Margaux Huot, Thomas Aparicio, Come Lepage, Julien Taieb, Olivier Bouche, Valerie Boige, Jean-Marc Phelip, Laetitia Dahan, Jaafar Bennouna, Karine Le Malicot, Olayide Boussari, Jean-Marc Gornet
Summary: This study examined the relationship between carcinoembryonic antigen (CEA) kinetics and prognosis in metastatic colorectal cancer (mCRC) patients receiving first-line chemotherapy in the PRODIGE9 trial. Three CEA trajectory classes were identified, with class 3 having the worst prognosis and being associated with ECOG 2 status, high LDH level, and non-resected primary tumor.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Oncology
Siyu Zhou, Nengquan Sheng, Jiazi Ren, Qian He, Yaya Zhang, Jianfeng Gong, Zhigang Wang
Summary: Recent research has shown that postoperative carcinoembryonic antigen (CEA) levels are an important indicator of colorectal cancer prognosis, and incorporating post-CEA into prognostic models significantly improves predictive performance. Developing prognostic nomograms and a prediction model for post-CEA elevation may help identify patients who require more intensive postoperative CEA surveillance.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xianzhe Li, Lara Stassen, Petra Schrotz-King, Zitong Zhao, Rafael Cardoso, Janhavi R. Raut, Megha Bhardwaj, Hermann Brenner
Summary: This systematic review evaluated fecal carcinoembryonic antigen (FCEA) as a biomarker for the noninvasive diagnosis and diagnosis of colorectal cancer (CRC). The study found significant differences in FCEA levels between CRC and control groups, and the diagnostic performance of FCEA was superior to that of serum carcinoembryonic antigen (SCEA), suggesting its potential role as a novel and easily measurable biomarker for the diagnosis of CRC. However, more comprehensive evaluation in screening settings is needed due to limited evidence from clinical studies.
Article
Biotechnology & Applied Microbiology
Yan Liu, Jie Chen
Summary: The objective of this study was to examine the levels of miR-497, CEA, CA24-2, and HBsAg in CRC patients and evaluate their clinical significance. The results showed that combined detection had the best diagnostic effect in CRC. miR-497, CEA, and CA24-2 were important for diagnosing lymph node metastasis of CRC, while HBsAg was more effective in predicting liver metastases. High levels of CEA significantly reduced the cumulative survival rate of CRC patients and could predict long-term survival. Serum levels of miR-497, CEA, CA24-2, and HBsAg played a positive role in the diagnosis and evaluation of CRC and had a high clinical guidance value in identifying lymph node and liver metastases.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Xiao-Dong Zhu, Li-Xiang Zhang, Pan-Quan Luo, Hai Zhu, Zhi-Jian Wei, A-Man Xu
Summary: This study found that the elevation of tumor markers CEA and CA19-9 before and after gastric cancer surgery is associated with poor prognosis, and this increment has a greater impact on prognosis than preoperative CEA/CA19-9 levels. A new prognostic model was established and shown to have reliable accuracy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liqiang Li, Xinfeng Lin, Lin Wang, Xiaopan Ma, Ziqing Zeng, Futao Liu, Bing Jia, Hua Zhu, Aiwen Wu, Zhi Yang
Summary: A novel CEA-targeted nanobody radiotracer, [68 Ga]Ga-HNI01, was developed and evaluated in preclinical xenografts and patients with colorectal carcinoma (CRC). The results showed that [68 Ga]Ga-HNI01 exhibited excellent tumor imaging ability and biodistribution profiles, making it an effective and convenient tool for detecting CRC lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Fotios Loupakis, Shruti Sharma, Madiha Derouazi, Sabina Murgioni, Paola Biason, Mario Domenico Rizzato, Cosimo Rasola, Derrick Renner, Svetlana Shchegrova, Allyson Koyen Malashevich, Meenakshi Malhotra, Himanshu Sethi, Bernhard G. Zimmermann, Alexey Aleshin, Solomon Moshkevich, Paul R. Billings, Jonathon D. Sedgwick, Marta Schirripa, Giada Munari, Umberto Cillo, Pierluigi Pilati, Angelo Paolo Dei Tos, Vittorina Zagonel, Sara Lonardi, Matteo Fassan
Summary: This study suggests that ctDNA-based MRD analysis is a significant prognostic biomarker in patients with metastatic colorectal cancer undergoing resection, providing valuable information for clinical decision making, clinical trial design, and translational research.
JCO PRECISION ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caroline Bodet-Milin, Alain Faivre-Chauvet, Thomas Carlier, Catherine Ansquer, Aurore Rauscher, Eric Frampas, Frederique Toulgoat, Damien Masson, Mickael Bourgeois, Evelyne Cerato, Vincent Rohmer, Olivier Couturier, Delphine Drui, David M. Goldenberg, Robert M. Sharkey, Jacques Barbet, Francoise Kraeber-Bodere
Summary: The study optimized pretargeting parameters for the use of anti-carcinoembryonic antigen (CEA) bispecific monoclonal antibody TF2 and the 68 Ga-labeled IMP288 peptide for immuno-PET in medullary thyroid carcinoma (MTC) patients. The immuno-PET showed a higher overall sensitivity than F-18-DOPA PET/CT for detecting metastases, except for lung metastases where CT remained the most effective examination.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Materials Science, Biomaterials
Nanhang Zhu, Guohao Li, Juan Zhou, Yujia Zhang, Ke Kang, Binwu Ying, Qiangying Yi, Yao Wu
Summary: In this study, a FRET magnetic aptamer-sensor was developed for rapid and efficient detection of exosomes, with a detection limit of 13 particles per mL and 100% accuracy in screening a specific cancer antigen. This system shows promising potential for liquid biopsy in lung cancer detection.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Obstetrics & Gynecology
Marcos Marangoni, Montas Laporte, Fernanda Surita, Maria B. Kraft, Luis Bahamondes, Cassia R. T. Juliato
Summary: The 1-year follow-up study on post-placental insertion of TCu380A-IUD and LNG-IUS found that device expulsion was more common among users of TCu380A-IUD and women who had vaginal delivery.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Cell Biology
Meng Pan, Tixia Xiao, Lai Xu, Yong Xu, Wei Ge
Summary: In this study, it was found that UTP18 is consistently upregulated in the progression of colorectal adenoma to carcinoma and is associated with adenoma recurrence, effective serodiagnosis, and poor prognosis of CRC. Furthermore, deSUMOylation induces the nucleocytoplasmic transport of UTP18, driving cell-cycle progression and tumorigenesis via mediation of the instability of p21 mRNA. UTP18 contributes to multiple roles in adenogenesis and malignancy of CRC, suggesting that it could be a potential biomarker and drug target for colorectal adenoma and cancer.
Article
Oncology
Zhenhui Li, Dafu Zhang, Xiaolin Pang, Shan Yan, Ming Lei, Xianshuo Cheng, Qian Song, Le Cai, Zhuozhong Wang, Dingyun You
Summary: The study investigated the prognostic value of postoperative CEA levels in patients with stage II colorectal cancer, finding that elevated CEA levels at 2-3 months after surgery were associated with an increased risk of recurrence but not overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hao Cai, Yu Chen, Qiao Zhang, Yang Liu, HouJun Jia
Summary: This study investigated the prognostic significance of preoperative CEA and C-SIRI in patients with resectable colorectal cancer. The results showed that high preoperative C-SIRI was significantly correlated with poorer overall survival and can serve as an important prognostic biomarker.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tae-Hoon Lee, Ji-Seon Kim, Se-Jin Baek, Jung-Myun Kwak, Jin Kim
Summary: This study aimed to evaluate the diagnostic accuracy of CEA for detecting colorectal cancer recurrence in patients with normal and elevated initial CEA levels. The results showed that the diagnostic accuracy of CEA depends on the initial CEA level, and an increase in CEA level at recurrence is significantly associated with overall survival in patients with recurrent colorectal cancer.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
Summary: This study found an association between childhood cancer and birth defects, with a stronger association observed among females. However, birth defects did not fully explain the differences in childhood cancer risk by sex, suggesting the involvement of other biological pathways.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Hematology
Nils Skajaa, Jan P. Vandenbroucke, Claus Ziegler Simonsen, Henrik Toft Sorensen, Kasper Adelborg
Summary: Cerebral venous thrombosis (CVT) mainly affects young to middle-aged women. The prognosis of patients with CVT varies according to their age and sex. CVT patients have an increased risk of venous thromboembolism (VTE) at other sites, ischemic stroke, major bleeding, and mortality. The risks differ between age groups and sexes.
Article
Surgery
Anne-Line Volden Havshoi, Ulrik Deding, Sofie Sajan Jensen, Per Vadgaard Andersen, Lasse Kaalby, Issam Al-Najami
Summary: CCE had lower completion rates compared to CT colonography and AA colonoscopy, but showed higher polyp detection rates. The completion rate of CCE following incomplete colonoscopy was suboptimal in this study.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Pernille O. Larsen, Nikolaj Nerup, Jesper Andersen, Niclas Dohrn, Mads Falk Klein, Steffen Brisling, Soren Salomon, Per Andersen, Soren Moller, Morten B. S. Svendsen, Hans B. Rahr, Lene H. Iversen, Ismail Gogenur, Niels Qvist, Mark B. Ellebaek
Summary: This study evaluated the inter-observer variation among surgeons in the interpretation of bowel blood perfusion assessed visually by ICG-FI, and compared the results between patients with and without AL using visual assessment and quantitative pixel analysis. The results showed wide inter-observer variation in the surgeon's visual assessment of ICG-FI, with no differences between patients with and without AL. However, quantitative pixel analysis showed a significant difference between groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Public, Environmental & Occupational Health
Buket Ozturk Esen, Vera Ehrenstein, Mette Norgaard, Henrik Toft Sorensen, Lars Pedersen
Summary: By incorporating information on repeatedly redeemed prescriptions and redemptions of drug classes commonly used in pregnancy, this study aimed to reduce bias from exposure misclassification in assessing the effect of prenatal antidepressant-ADHDrelationship. The results did not support the hypothesis that prenatal antidepressant exposure increases the risk of ADHD.
Article
Obstetrics & Gynecology
Ellen Margrethe Mikkelsen, Sinna Pilgaard Ulrichsen, Benjamin Randeris Johannesen, Anne Sofie Dam Laursen, Lauren Anne Wise, Elizabeth Elliott Hatch, Kenneth Jay Rothman, Amelia Kent Wesselink, Holly Crowe, Henrik Toft Sorensen
Summary: This study assessed the association between preconception antibiotic use and fecundability. The results showed that the use of antibiotics, especially sulfonamides and macrolides, was associated with decreased fecundability.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Cecilia Hvitfeldt Fuglsang, Lars Pedersen, Morten Schmidt, Jan Vandenbroucke, Hans Erik Botker, Henrik Toft Sorensen
Summary: This study used Danish national registries to examine the impact of migraine on the risk of premature myocardial infarction (MI) and ischemic/hemorrhagic stroke among men and women. They found that migraine was associated with similarly increased risk of premature ischemic stroke among both men and women, but there may be an increased risk of MI and hemorrhagic stroke only among women.
Article
Oncology
Jonas Kabel, Tenna Vesterman Henriksen, Christina Demuth, Amanda Frydendahl, Mads Heilskov Rasmussen, Jesper Nors, Nicolai J. Birkbak, Anders Husted Madsen, Uffe S. Love, Per Vadgaard Andersen, Thomas Kolbro, Alessio Monti, Ole Thorlacius-Ussing, Mikail Gogenur, Jeppe Kildsig, Nis Hallundbaek Schlesinger, Peter Bondeven, Lene Hjerrild Iversen, Kare Andersson Gotschalck, Claus Lindbjerg Andersen
Summary: Investigating the impact of tumor cell whole-genome doubling (WGD) on the detection of circulating tumor DNA (ctDNA), it was found that tumors with WGD have a higher likelihood of ctDNA detection. This is particularly significant for early-stage cancer. The study suggests that ctDNA is a promising biomarker for the early detection of cancer and residual disease.
Article
Public, Environmental & Occupational Health
Min Hee Kim, Else Foverskov, Trine Froslev, Justin S. White, M. Maria Glymour, Jens Hainmueller, Lars Pedersen, Henrik T. Sorensen, Rita Hamad
Summary: This study found that neighborhood disadvantage has a positive effect on the health of refugees, reducing mortality risk. However, it increases mortality risk among non-refugee immigrants and native-born Danes.
SSM-POPULATION HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Kasper Bonnesen, Frederikus A. Klok, Mads J. Andersen, Asger Andersen, Jens E. Nielsen-Kudsk, Soren Mellemkjaer, Henrik T. Sorensen, Morten Schmidt
Summary: Pulmonary embolism as a risk factor for chronic thromboembolic pulmonary hypertension (CTEPH) and its impact on long-term mortality after venous thromboembolism (VTE) were examined. A nationwide cohort study of Danish patients without previous pulmonary hypertension (PH) was conducted, and the standardized mortality rate ratios (SMRs) were calculated. The results showed that PH diagnosed less than 2 years after incident VTE was associated with a twofold increased long-term mortality, mainly driven by cardiovascular causes.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Frederik Pagh Bredahl Kristensen, Diana Hedevang Christensen, Martin Bodtker Mortensen, Michael Maeng, Johnny Kahlert, Henrik Toft Sorensen, Reimar Wernich Thomsen
Summary: Triglyceride levels are associated with cardiovascular risk in newly diagnosed type 2 diabetes patients who are already on statin therapy. High triglyceride levels may serve as a predictor of residual cardiovascular risk in early type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Clinical Neurology
Nils Skajaa, Dora Koermendine Farkas, Kasper Adelborg, Henrik Toft Sorensen
Summary: Patients with CVT do not have an overall increased risk of cancer diagnosis, except for the first three months after diagnosis when the risk increases by more than 7-fold. However, a prior diagnosis of CVT does not negatively impact cancer survival.
Article
Public, Environmental & Occupational Health
Natasja Koitzsch Jensen, Trine Froslev, Else Foverskov, Maria Glymour, Henrik Toft Sorensen, Rita Hamad
Summary: Neighborhood socioeconomic disadvantage is associated with cardiovascular health, with neighborhood-level income and education being most consistently related to cardiovascular risk factors, while welfare transfers are most consistently associated with cardiovascular disease. Addressing these specific aspects of neighborhood disadvantage could therefore lower the risk of poor cardiovascular health among refugees.
Article
Respiratory System
Nils Skajaa, Kristina Laugesen, Erzsebet Horvath-Puho, Henrik Toft Sorensen
Summary: This study compares the prevalence, incidence, and prognostic impact of different comorbidities among patients with COPD and the general population in Denmark.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Clinical Neurology
Frederikke Bach, Nils Skajaa, Buket Ozturk Esen, Cecilia Hvitfeldt Fuglsang, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Kasper Adelborg
Summary: Compared to moderate-intensity statin treatment, initiating high-intensity statins after ischemic stroke is associated with similar risks of most effectiveness and safety outcomes. However, it reduces the risk of mortality and increases the risk of diabetes.
EUROPEAN STROKE JOURNAL
(2023)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
