Interactions of APOBEC3s with DNA and RNA

Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains

(2020) Atanu Maiti et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma

(2019) Vincent L. Cannataro et al.   ONCOGENE

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

(2019) Mia Petljak et al.   CELL

Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA

(2019) Xiaoxuan Yan et al.   Chemistry-An Asian Journal

Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features

(2019) Rémi Buisson et al.   SCIENCE

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

(2019) Abby M. Green et al.   DNA REPAIR

Molecular Interactions of a DNA Modifying Enzyme APOBEC3F Catalytic Domain with a Single-Stranded DNA

(2018) Yao Fang et al.   JOURNAL OF MOLECULAR BIOLOGY

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

(2018) Nadine M. Shaban et al.   MOLECULAR CELL

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies

(2018) Samantha J. Ziegler et al.   PLoS One

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

(2018) Atanu Maiti et al.   Nature Communications

Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H

(2018) Fumiaki Ito et al.   Scientific Reports

Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins

(2017) Fumiaki Ito et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

(2017) Jennifer A. Bohn et al.   Nature Communications

Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G

(2017) Michael Morse et al.   Nature Communications

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

(2017) Takahide Kouno et al.   Nature Communications

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B

(2017) Ke Shi et al.   Scientific Reports

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

(2016) K. Nishida et al.   SCIENCE

Crystal structures of APOBEC3G N-domain alone and its complex with DNA

(2016) Xiao Xiao et al.   Nature Communications

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B

(2014) Valdimara C. Vieira et al.   mBio

The inhibition of hepatitis B virus by APOBEC cytidine deaminases

(2013) E. M. Janahi et al.   JOURNAL OF VIRAL HEPATITIS

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

(2013) S. Harjes et al.   JOURNAL OF VIROLOGY

APOBEC3 Deaminases Induce Hypermutation in Human Papillomavirus 16 DNA upon Beta Interferon Stimulation

(2013) Z. Wang et al.   JOURNAL OF VIROLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

Nanoscale Structure and Dynamics of ABOBEC3G Complexes with Single-Stranded DNA

(2012) Luda S. Shlyakhtenko et al.   BIOCHEMISTRY

Genetic Editing of Herpes Simplex Virus 1 and Epstein-Barr Herpesvirus Genomes by Human APOBEC3 Cytidine Deaminases in Culture and In Vivo

(2011) R. Suspene et al.   JOURNAL OF VIROLOGY

Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G

(2010) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

(2009) Yeshitila N Friew et al.   Retrovirology

Human Cytidine Deaminase APOBEC3H Restricts HIV-1 Replication

(2008) Ying Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins

(2008) R. S. LaRue et al.   JOURNAL OF VIROLOGY

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

(2008) Lauren G. Holden et al.   NATURE

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE