Regulation and function of class A Penicillin-binding proteins

A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW

(2021) Xinxing Yang et al.   Nature Microbiology

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi‐enzyme complexes in Escherichia coli

(2020) Manuel Banzhaf et al.   EMBO JOURNAL

Substrate and Stereochemical Control of Peptidoglycan Cross-Linking by Transpeptidation by Escherichia coli PBP1B

(2020) Anita C. Catherwood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall

(2020) Daniel Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects

(2020) Antoine Vigouroux et al.   eLife

Regulation of peptidoglycan synthesis and remodelling

(2020) Alexander J. F. Egan et al.   NATURE REVIEWS MICROBIOLOGY

Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex

(2020) Megan Sjodt et al.   Nature Microbiology

Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa

(2020) Nathanael A. Caveney et al.   STRUCTURE

Uncovering Unappreciated Activities and Niche Functions of Bacterial Cell Wall Enzymes

(2020) Allison K. Daitch et al.   CURRENT BIOLOGY

A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase

(2020) Lindsey S. Marmont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

(2020) Jad Sassine et al.   Scientific Reports

A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

(2020) Yesha Patel et al.   eLife

The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b

(2020) Adrien Boes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN

(2019) Adrien Boes et al.   mBio

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

(2019) Atsushi Taguchi et al.   Nature Microbiology

A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus

(2019) Maria Billini et al.   PLoS Genetics

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

(2019) Niccolò Morè et al.   mBio

Simultaneously inhibiting undecaprenyl phosphate production and peptidoglycan synthases promotes rapid lysis in Escherichia coli

(2019) Matthew A. Jorgenson et al.   MOLECULAR MICROBIOLOGY

Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

(2019) Elizabeth A Mueller et al.   eLife

SEDS–bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus

(2019) Nathalie T. Reichmann et al.   Nature Microbiology

Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems

(2019) Michael F. Dion et al.   Nature Microbiology

Upregulation of PBP1B and LpoB in cysB mutants confers mecillinam resistance in Escherichia coli

(2019) Elisabeth Thulin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

(2018) Megan Sjodt et al.   NATURE

Conserved mechanism of cell-wall synthase regulation revealed by the identification of a new PBP activator inPseudomonas aeruginosa

(2018) Neil G. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced conformational changes activate the peptidoglycan synthase PBP1B

(2018) Alexander J. F. Egan et al.   MOLECULAR MICROBIOLOGY

Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

(2018) Manuel Pazos et al.   Nature Communications

PBP1B Glycosyltransferase and Transpeptidase Activities Play Different Essential Roles during the De Novo Regeneration of Rod Morphology in Escherichia coli

(2017) Dev K. Ranjit et al.   JOURNAL OF BACTERIOLOGY

LytM factors affect the recruitment of autolysins to the cell division site in Caulobacter crescentus

(2017) Aleksandra Zielińska et al.   MOLECULAR MICROBIOLOGY

Peptidoglycan in obligate intracellular bacteria

(2017) Christian Otten et al.   MOLECULAR MICROBIOLOGY

The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli

(2017) Ghee Chuan Lai et al.   PLoS Genetics

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

(2017) Sophie Leclercq et al.   Scientific Reports

Structural Insights into Inhibition ofEscherichia coliPenicillin-binding Protein 1B

(2016) Dustin T. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEDS proteins are a widespread family of bacterial cell wall polymerases

(2016) Alexander J. Meeske et al.   NATURE

Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

(2016) Monica Markovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule imaging reveals modulation of cell wall synthesis dynamics in live bacterial cells

(2016) Timothy K. Lee et al.   Nature Communications

Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

(2016) Jean-Emmanuel Hugonnet et al.   eLife

Mechanical Genomics Identifies Diverse Modulators of Bacterial Cell Stiffness

(2016) George K. Auer et al.   Cell Systems

Wall proficient E. coli capable of sustained growth in the absence of the Z-ring division machine

(2016) Romain Mercier et al.   Nature Microbiology

Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously

(2016) Hongbaek Cho et al.   Nature Microbiology

Activities and regulation of peptidoglycan synthases

(2015) Alexander J. F. Egan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

(2015) Andrew N Gray et al.   eLife

Differential Requirement for PBP1a and PBP1b inIn VivoandIn VitroFitness of Vibrio cholerae

(2014) Tobias Dörr et al.   INFECTION AND IMMUNITY

Function and Localization Dynamics of Bifunctional Penicillin-Binding Proteins in Caulobacter crescentus

(2014) W. Strobel et al.   JOURNAL OF BACTERIOLOGY

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

(2014) A. J. F. Egan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rcs Stress Response and Accessory Envelope Proteins Are Required for De Novo Generation of Cell Shape in Escherichia coli

(2013) D. K. Ranjit et al.   JOURNAL OF BACTERIOLOGY

Lipoprotein Activators Stimulate Escherichia coli Penicillin-Binding Proteins by Different Mechanisms

(2013) Tania J. Lupoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperativity of peptidoglycan synthases active in bacterial cell elongation

(2012) Manuel Banzhaf et al.   MOLECULAR MICROBIOLOGY

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

(2011) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

(2010) Catherine Paradis-Bleau et al.   CELL

Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

(2010) Athanasios Typas et al.   CELL

TolA Modulates the Oligomeric Status of YbgF in the Bacterial Periplasm

(2010) Anne Marie Krachler et al.   JOURNAL OF MOLECULAR BIOLOGY

Bactofilins, a ubiquitous class of cytoskeletal proteins mediating polar localization of a cell wall synthase in Caulobacter crescentus

(2009) Juliane Kühn et al.   EMBO JOURNAL

Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli

(2009) M.-T. Sung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editorial: Coactivators and Corepressors: What’s in a Name?

(2008) Bert W. O'Malley et al.   MOLECULAR ENDOCRINOLOGY