Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Article
Engineering, Biomedical
Timothy Samec, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant
Summary: This review discusses the application of peptide-based delivery systems in cancer therapeutics. Peptide systems can alleviate systemic side effects caused by current delivery strategies and enhance therapeutic delivery and cancer targetability.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Siyuan Zhang, Xin-Yue Lou, Linlin Liu, Ying-Wei Yang
Summary: DNA origami technology, a unique type of DNA nanotechnology, has attracted much attention from researchers and is applied in various fields. DNA origami nanostructures are endowed with excellent programmability and addressability and show outstanding biocompatibility in bio-related applications, especially in cancer treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Immunology
Zhongkun Zhang, Siyu Yao, Yingwen Hu, Xiaobin Zhao, Robert J. Lee
Summary: The article discusses the importance of immunotherapy in cancer treatment and recent applications of lipid-based nanoparticles in anticancer immunotherapy. Only a few cancer types of patients respond to immunotherapy, while high-dose treatments may lead to severe adverse events.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Hao Wang, Lingfeng Gao, Taojian Fan, Chen Zhang, Bin Zhang, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Swelm Wageh, Meng Qiu, Han Zhang
Summary: Nanomedicine strategies hold significant potential in smart drug delivery due to the unique composition of tumor tissue. Stimuli-responsive nanogels are increasingly important in cancer therapy, with the evolution from monoresponsive to multiresponsive systems. The properties, synthesis, and characterization of nanogels, as well as designing strategies for stimuli-response nanogels are discussed in this review, along with the potential applications of nanogel composites in constructing multistimulus-responsive nanoparticles for cancer diagnosis and therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Olivier Feron, Christiani A. Amorim
Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Haijing Qu, Han Chen, Wei Cheng, Yanjun Wang, Yangyang Xia, Linghao Zhang, Buyong Ma, Rong Hu, Xiangdong Xue
Summary: We propose a supramolecular assembly strategy to enhance drug loading, tumor targeting, and delivery simplicity for hydrophilic drugs. By co-assembling with other drugs, we validate the effectiveness of this strategy and demonstrate its application in anti-tumor activities.
ACTA BIOMATERIALIA
(2023)
Review
Pharmacology & Pharmacy
Chong Yu, Shuai Wang, Wing-Fu Lai, Dahong Zhang
Summary: Bladder cancer (BC) is the most common cancer of the urinary system and non-muscle-invasive bladder cancer (NMIBC) accounts for the majority of cases. Patients with NMIBC have a good survival rate but are at high risk for tumor recurrence and progression. The use of antitumor agents instilled into the bladder is the standard treatment for NMIBC, but their efficacy is limited due to chemo-resistance and poor drug retention. Chitosan-based nanoparticles offer a promising solution by enhancing drug penetration and improving biomedical applications in bladder cancer treatment.
Article
Cell Biology
Taranom Mobasheri, Elham Rayzan, Mahsima Shabani, Mina Hosseini, Ghanbar Mahmoodi Chalbatani, Nima Rezaei
Summary: Research focuses on developing new therapeutic strategies for neuroblastoma, targeting different genes and utilizing nano-drug delivery systems to improve treatment efficacy. The combination of specific drug targets and nano-drug delivery systems may lead to lower systemic side effects and improved therapeutic effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Kyumin Mo, Ayoung Kim, Soohyun Choe, Miyoung Shin, Hyunho Yoon
Summary: Lipid nanoparticles (LNPs) composed of ionized lipids, helper lipids, and cholesterol have potential for gene therapies and vaccines by facilitating intracellular transport and avoiding endosomal compartments. Solid lipid nanoparticles (SLNs) derived from physiologically acceptable lipids provide high structural stability and biocompatibility, and have been used to enhance drug delivery for cancer treatments. SLNs have shown promising results in breast cancer treatment, improving the therapeutic efficacy of drugs.
Review
Chemistry, Multidisciplinary
B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammad Ali Abdullah Almoyad, Shadma Wahab, Waleed H. Almalki, Prashant Kesharwani
Summary: Nanosponges, with their unique sponge-like structure, offer a promising solution for drug delivery in cancer therapy. By utilizing their interconnected voids and mesh-like network, nanosponges enable efficient drug loading and controlled release, overcoming the limitations of conventional methods. They show potential in both cancer treatment and diagnosis, and are considered versatile carrier systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Can Lei, Xiu-Ran Liu, Quan-Bing Chen, You Li, Jia-Li Zhou, Ling-Yue Zhou, Tao Zou
Summary: The combined utilization of albumin and HA as nanocarriers offers numerous advantages, including efficient targeting, reducible particle size, and pH and/or hyaluronidase sensitive drug release, contributing significantly to drug delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Amaal Abdulraqeb Ali, Waad H. Abuwatfa, Mohammad H. Al-Sayah, Ghaleb A. Husseini
Summary: Researchers believe that gold nanoparticle (GNP) hybrid nanostructures are promising multimodal candidates for cancer therapy, as they can achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. However, there is currently a lack of reviews summarizing the use of GNP nanohybrids for cancer treatment. Therefore, this review provides a critical analysis of GNP nanohybrid use in cancer therapy, with a focus on synergistic approaches.
Review
Environmental Sciences
Jyoti Chandra, Nazeer Hasan, Nazim Nasir, Shadma Wahab, Punniyakoti Veeraveedu Thanikachalam, Amirhossein Sahebkar, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: Skin cancer is a serious condition with a significant impact on global health. It is divided into two categories: melanoma skin cancer and non-melanoma skin cancer. Chemotherapy is considered the most acceptable form of treatment, but it has significant drawbacks such as severe toxicities and drug resistance. Nanotechnology-based combination therapy holds promise for enhancing targeted drug delivery to tumor cells and improving efficacy in skin cancer treatment.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Melody D. D. Fulton, Wided Najahi-Missaoui
Summary: Since their discovery in the 1960s, liposomes have been effective drug delivery systems for treating various cancers. However, their translation into the clinic has been incremental due to potential toxicity and lack of specific targeting. This review summarizes the properties of liposomes, their current status in cancer therapy, and the challenges they face.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Guangxu Lan, Yangjian Quan, Maolin Wang, Geoffrey T. Nash, Eric You, Yang Song, Samuel S. Veroneau, Xiaomin Jiang, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Taokun Luo, Kaiyuan Ni, August Culbert, Guangxu Lan, Zhe Li, Xiaomin Jiang, Michael Kaufmann, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Yangjian Quan, Yang Song, Wenjie Shi, Ziwan Xu, Justin S. Chen, Xiaomin Jiang, Cheng Wang, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Kaiyuan Ni, Taokun Luo, August Culbert, Michael Kaufmann, Xiaomin Jiang, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Xiang Ling, Xiaomin Jiang, Youyou Li, Wenbo Han, Megan Rodriguez, Ziwan Xu, Wenbin Lin
Summary: The combination of antiangiogenesis and chemotherapy regimens with cancer immunotherapy using bioresponsive nanoparticles could inhibit angiogenesis, induce tumor cell apoptosis, and activate immune responses in tumor microenvironments, thus promoting antitumor immunity and inhibiting tumor growth.
Article
Chemistry, Multidisciplinary
Yangjian Quan, Wenjie Shi, Yang Song, Xiaomin Jiang, Cheng Wang, Wenbin Lin
Summary: A bifunctional metal-organic layer, Hf-EY-Fe, designed by bridging EY-capped Hf-6 SBUs with Fe-TPY ligands, efficiently catalyzes various reactions on alkenes and synthesis of CF3-substituted derivatives of large bioactive molecules. The proximity between EY and iron centers in Hf-EY-Fe enhances catalytic activity and inhibits mutual deactivation, resulting in high turnover numbers and good recyclability of the MOL catalyst.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Taokun Luo, Geoffrey T. Nash, Ziwan Xu, Xiaomin Jiang, Jianqiao Liu, Wenbin Lin
Summary: The study presents a new strategy of loading poorly soluble photosensitizers into nanoscale metal-organic frameworks to enhance ROS generation, resulting in improved photodynamic therapy efficacy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemical Research Methods
Youyou Li, Wenbo Han, Chunbai He, Xiaomin Jiang, Yingjie Fan, Wenbin Lin
Summary: The study demonstrated the design of carb/pyro nanoscale coordination polymer nanoparticles for the treatment of breast and colorectal cancer, showing promising anticancer efficacy in mouse models. Additionally, the combination therapy of carb/pyro with light irradiation and an anti-CD47 antibody achieved complete eradication of tumors in certain mice.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Wenjie Shi, Yangjian Quan, Guangxu Lan, Kaiyuan Ni, Yang Song, Xiaomin Jiang, Cheng Wang, Wenbin Lin
Summary: Tandem catalytic reactions using bifunctional metal-organic layers show high efficiency in transforming hydrocarbons into cyanohydrins or styrenes into styrene carbonates. These layers have the potential to be a tunable platform for incorporating multiple catalysts for tandem transformations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J. Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R. Weichselbaum, Wenbin Lin
Summary: This study reports a novel nanomedicine strategy for co-delivering combination chemotherapies to tumors using a designed nanoparticle system. The nanoparticles contain hydrophilic and hydrophobic prodrugs that target tumors actively through the LDL receptor. These nanoparticles selectively release the drugs in the acidic, esterase-rich, and reducing tumor microenvironments, leading to higher drug accumulations and significant tumor growth inhibition without causing serious side effects.
Correction
Chemistry, Multidisciplinary
Kaiyuan Ni, Taokun Luo, August Culbert, Michael Kaufmann, Xiaomin Jiang, Wenbin Lin
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin
Summary: This study reports a two-stage release strategy to effectively deliver oxaliplatin and SN38 chemotherapy drugs to tumors using nanoparticles, reducing general toxicity. Compared to other chemotherapy drugs, this strategy can decrease the exposure of SN38 in the blood and increase exposure in tumors. The results show that these nanoparticles have a significant inhibitory effect on tumors in vivo without causing side effects. Furthermore, the study also found that the nanoparticles can enhance immunogenic cell death and promote tumor immune response. This research highlights the potential of combining prodrug design and nanomedicine formulation.
Article
Engineering, Biomedical
Xiaomin Jiang, Jianqiao Liu, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J. Lee, Wenbin Lin
Summary: Conventional chemotherapy alone may fail due to the plasticity of tumor cells acquiring chemo-resistance. This study demonstrates that high-dose pharmacologic ascorbate, in combination with nanoscale coordination polymers (NCPs) delivering chemotherapeutics, can effectively reduce cancer stem cells (CSCs) in solid tumors and inhibit tumor recurrence and metastasis in mouse models of cancer.
Article
Chemistry, Multidisciplinary
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin
Summary: In this study, a novel nanoscale metal-organic framework (nMOF) Hf-TP-SN, containing an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug, was designed for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, Hf-12 secondary building units served as radiosensitizers to enhance the generation of hydroxyl radicals, leading to the on-demand release of SN38. The Hf-TP-SN showed 5-fold higher release of SN38 compared to its molecular counterpart, resulting in significant cytotoxicity to cancer cells and efficient tumor growth inhibition in colon and breast cancer mouse models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)