Article
Materials Science, Biomaterials
Wanru Sun, Hui Yu, Deqiang Wang, Youjie Li, Baocheng Tian, Shuang Zhu, Ping-Yu Wang, Shuyang Xie, Ranran Wang
Summary: A multifunctional theranostic platform (MnO2-SiO2-APTES&Ce6 (MSA&C)) incorporating PDT and NIR-II photothermal therapy was developed based on MnO2 nanoflowers. The platform effectively loaded photosensitizer, relieved tumor hypoxia, and provided tumor-specific imaging. The combination of PDT and NIR-II PTT showed improved therapeutic efficacy by enhancing ROS generation and down-regulating HSP 70 expression.
BIOMATERIALS SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Zhenzhen Chen, Qian Zhang, Qinbiao Huang, Zhihong Liu, Lingjun Zeng, Lingna Zhang, Xu Chen, Hongtao Song, Jialiang Zhang
Summary: This study presents a new strategy for inducing immunogenic cell death (ICD) using photothermal MnO2 nanoparticles in tumor immunotherapy. By loading the ICD inducer DOX onto the MnO2 nanoparticles, high photothermal conversion efficiency, efficient tumor targeting, TME-responsive release of DOX, and modulation of the hypoxic TME were achieved. The combination of chemo-photothermal therapy-induced ICD and improvement of the immunosuppressive TME showed a significant synergistic therapeutic effect in a mouse model of triple-negative breast carcinoma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Lu Chen, Gaojie Chen, Kang Hu, Lianxu Chen, Zhiyong Zeng, Bin Li, Guohua Jiang, Yang Liu
Summary: A composite hydrogel consisting of PAA and F127 was developed, which incorporates ZCND and erastin for post-surgical cancer treatment. The combined effect of PDT and PTT with ZCND-erastin hydrogel effectively suppresses tumor recurrence and mortality in mice with resected tumors. The study offers innovative insights into the synergistic application of ferroptosis therapy and the prevention of post-surgical tumor recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Mengzhu Zhang, Xiaohan Qin, Wei Xu, Yibing Wang, Yunmei Song, Sanjay Garg, Yuxia Luan
Summary: This study introduces a novel dual-modal phototherapeutic nanoplatform that achieves both PDT and PTT under single 660 nm laser irradiation by integrating core-shell structured CuS@Carbon with Ce6.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Nanoscience & Nanotechnology
Cunqing Kong, Xingcai Chen
Summary: This article summarizes the importance and development of photoactivation therapy based on photodynamic therapy (PDT) and photothermal therapy (PTT) in tumor treatment. Photosensitizers and photothermal conversion agents play a key role in the phototherapy process. The advancement of nanotechnology has promoted the application of phototherapy in tumor treatment. PDT can increase the sensitivity of tumor cells to PTT, while PTT can enhance the therapeutic effect of PDT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Shiliang He, Xiao Jia, Sai Feng, Junqing Hu
Summary: This review examines the effectiveness of three strategies for developing advanced phototherapeutics based on various tumor microenvironment characteristics. The first strategy involves targeted delivery of phototherapeutics to tumors with the assistance of tumor microenvironment-induced nanoparticle disassembly or surface modification. The second strategy involves near-infrared absorption increase-induced phototherapy activation triggered by tumor microenvironment factors. The third strategy involves enhancing therapeutic efficacy by ameliorating the tumor microenvironment.
Article
Pharmacology & Pharmacy
Wen-Jie Zheng, Ze-Lei Zhou, Qi-Yan Lv, Xiaojie Song, Wen-Xing Zhang, Hui-Fang Cui
Summary: In this study, a nanocarrier was developed to enhance photodynamic and photothermal combined tumor therapy. The nanocarrier has double responsive characteristics, generating heat and O-2 at mild-hyperthermia temperatures. It demonstrated strong anti-tumor effects in testing and showed good biosafety. The multifunctional nanocarrier provides a platform for various therapeutic agents to modulate the tumor microenvironment and enhance tumor therapy efficiency.
ADVANCED THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Bei Li, Xiwen Ye, Yi Fu, Lei Feng, Jianrong Xu, Xiaoya Niu, Hui Ye, Zhen You
Summary: This study presents a novel therapeutic nanoprobe that addresses the challenges of cancer monotherapy, such as hypoxic microenvironment, insufficient drug concentration, and increased drug tolerance. The nanoprobe effectively combines photothermal, photodynamic, and chemodynamic therapy to improve the efficacy of liver cancer treatment.
PHARMACEUTICAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Zixing Liang, Xiaofeng Li, Xiaofang Chen, Jiawei Zhou, Yanan Li, Jianhui Peng, Zhousheng Lin, Gai Liu, Xiancheng Zeng, Cheng Li, Lifeng Hang, Hailiang Li
Summary: A nanoparticle composed of indocyanine green (ICG) and Fe-MOF-5 was developed to overcome the limitations of complexity and irreversible hypoxia environment generated by tumor tissues. It showed good tumor inhibition effect in vitro and in vivo, and has broad application prospects in the field of tumor therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Chemical
Darieo Thankachan, Rajeshkumar Anbazhagan, Rajakumari Krishnamoorthi, Hsieh Chih Tsai, Hailemichael Tegenu Gebrie, Haile Fentahun Darge, Chien-Hsing Lu, Jem-Kun Chen
Summary: A polyelectrolyte-stabilized MnO2 nanoparticle system was developed for combined PDT and PTT therapy, showing superior efficiency compared to single systems. The system demonstrated excellent therapeutic effects against cancer cells.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Chemistry, Applied
Dongxin Wang, Xingchen Mu, Xin Chen, Heyong Huang, Lin Zhou, Shaohua Wei
Summary: The study utilized PCD as a linker to combine transition metal nanomaterials with functional molecules for synergistic photothermal and photodynamic tumor therapy.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Lipeng Zhu, Yunlu Dai, Lizeng Gao, Qi Zhao
Summary: Reactive oxygen species (ROS) play important roles in the cell cycle, and disrupting ROS homeostasis in the tumor microenvironment is recognized as an ideal antitumor strategy. The study developed a novel theranostic nanoagent based on PEG@Cu2-xS@Ce6 nanozymes (PCCNs) and demonstrated their effectiveness in generating ROS, inducing photodynamic therapy (PDT) and photothermal therapy (PTT), and depleting glutathione (GSH). The PCCNs showed promising antitumor efficacy in vitro and in vivo by disrupting ROS homeostasis and enhancing therapy under the guidance of photothermal/photoacoustic imaging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Article
Biochemistry & Molecular Biology
Bei Li, Xiaodong Wang, Shasha Hong, Qi Wang, Lin Li, Omer Eltayeb, Chuan Dong, Shaomin Shuang
Summary: The PPy@MnO2 nanocomposites were synthesized by anchoring MnO2 nanosheets on PPy nanoparticles, and further modified with PEG and MB to create a multifunctional nanoarchitecture for combined PTT and PDT treatment of tumors. The system demonstrated excellent photothermal properties with high temperature elevation and efficient PDT through increased O-1(2) generation under acidic conditions. Cellular uptake studies confirmed the effectiveness of the nanotherapeutic system in HeLa cells, showing enhanced PDT efficacy with MnO2 nanosheets. The nanotherapeutic system exhibited superior biocompatibility and significantly reduced cell viabilities in the combined PTT and PDT group.
Article
Engineering, Biomedical
Xiaoge Zhang, Junjie Tang, Chao Li, Yao Lu, Lili Cheng, Jie Liu
Summary: Photo-immunotherapy using black phosphorus nanoparticles modified with hyaluronic acid shows excellent therapeutic efficacy through combined photothermal and photodynamic therapy, remodeling tumor-associated macrophages and inducing immunogenic cell death. The nanoparticles selectively accumulate at the tumor site and induce antitumor immune responses by releasing DAMPs.
BIOACTIVE MATERIALS
(2021)
Article
Biophysics
Yuancun Cheng, Xiaoyi Zheng, Liying Zhang, Jiulong Zhao, Lianghao Hu, Shige Wang
Summary: This study demonstrates a feasible strategy to enhance the permeability of nanoparticles to pancreatic tumors. By synthesizing polypyrrole nanoparticles (PPy NPs) and loading the anticancer drug doxorubicin (DOX) within them, the release of DOX is intelligently controlled using a thermoresponsive ligand lauric acid (LA). The grafting of bromelain (BL) onto the surface of PPy-LA NPs or PPy-LA/DOX NPs enhances the permeability of DOX to pancreatic tumors. Moreover, the resulting PLB NPs also exhibit photothermal conversion and photoacoustic imaging capabilities, enabling imaging-guided tumor ablation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Yongliang Ouyang, Jiulong Zhao, Shige Wang
Summary: Hydrogel, as a water-rich polymer material, is widely used in the biomedical field due to its unique physical and chemical properties and good biocompatibility. With the increasing incidence of inflammatory bowel disease (IBD) in recent years, traditional drug treatments have shown limitations, resulting in an urgent need for new therapies. Hydrogel has emerged as a potential therapeutic platform for IBD, but there is a lack of comprehensive review on functional hydrogels for IBD treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhirui Zhang, Jiulong Zhao, Zheng Chen, Hang Wu, Shige Wang
Summary: In this study, a simple and economical method was reported to synthesize MoS2-PEG@BSA (MPB) nanosheets, which possess the ability to scavenge different types of reactive oxygen species and mimic the activities of catalase, superoxide dismutase, and glutathione peroxidase. The biocompatibility of the MPB platform was greatly improved by modification with bovine serum albumin, and it effectively relieved acute liver injury caused by oxidative stress. Both in vitro and in vivo experiments confirmed the biocompatibility and efficiency of MPB nanosheets in cell protection.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Applied
Zheng Chen, Jiulong Zhao, Hang Wu, Haibin Wang, Xuhua Lu, Mohammad -Ali Shahbazi, Shige Wang
Summary: This study prepared a novel CMCS/ODex/gamma-PGA hydrogel for the treatment of diffuse and incompressible wound bleeding. The hydrogel showed good hemostatic effect and maintained adhesion in wet environments. This study provides a new method for designing wet-surface adhesives for efficient hemostasis.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Yang Yu, Xiaoyi Zheng, Xiuying Liu, Jiulong Zhao, Shige Wang
Summary: An injectable PCP hydrogel was developed to reduce post-operative infection and prevent tumor recurrence. The hydrogel effectively killed tumor cells and bacteria, and exhibited anti-bacterial and anti-tumor properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Xia Xu, Yanbo Zeng, Zheng Chen, Yang Yu, Haibin Wang, Xuhua Lu, Jiulong Zhao, Shige Wang
Summary: A composite hydrogel called QMPD hydrogel, composed of QCS-MA, PVP, and DA, was developed for wound healing. The hydrogel formation is triggered by ultraviolet light and involves hydrogen bonds, electrostatic interactions, and pi-pi stacking. The hydrogel exhibits bacteriostatic and anti-inflammatory properties, promoting wound management in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Zheng Chen, Xiaoyi Zheng, Jiulong Zhao, Jingwen Tang, Lianghao Hu, Shige Wang
Summary: This study proposes a chemical modification method to immobilize glucose oxidase (GOx) on the surface of a photothermal transducing agent for safe and combined starvation and photothermal therapy of colorectal tumors. Under near-infrared laser irradiation, the photothermal transducing agent generates thermal energy to locally kill colorectal cancer cells. The study is expected to provide a new avenue for the rational design of multifunctional nanotherapeutics for tumor therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yang Yu, Peng Fan, Jinfeng Li, Shige Wang
Summary: In this study, composite nanoparticles of manganese dioxide and selenite were prepared and modified with bovine serum protein to improve their stability under physiological conditions. These nanoparticles exhibited acid-responsive, catalytic, and antioxidant properties. Experimental results confirmed their acid response, catalytic activity, and antioxidant properties, as well as their good biosafety in vitro and in vivo. Therefore, this study contributes to the design of high-performance therapeutic agents that can overcome the limitations of the tumor microenvironment.
Review
Polymer Science
Jiahao Yang, Shige Wang
Summary: This review discusses the design criteria and functionalities of hydrogel bio-adhesives for wound healing and comprehensively explores recent advances in polysaccharide-based multifunctional hydrogel bio-adhesives. Polysaccharides such as chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, and others are discussed. The current challenges and future research directions of polysaccharide-based hydrogel bio-adhesives for wound healing are proposed.
Article
Polymer Science
Xiaoyi Zheng, Hang Wu, Shige Wang, Jiulong Zhao, Lianghao Hu
Summary: In recent years, multifunctional hydrogel nanoplatforms for the synergistic treatment of tumors have received a great deal of attention. Here, we prepared an iron/zirconium/polydopamine/carboxymethyl chitosan hydrogel with Fenton and photothermal effects, promising for future use in the field of synergistic therapy and prevention of tumor recurrence.
Article
Chemistry, Physical
Hang Wu, Lei Xie, Shige Wang, Tengbo Yu, Yingze Zhang
Summary: This paper presents a biocompatible therapeutic nanoplatform for the treatment of osteosarcoma (OS) that combines tumor inhibition efficiency with fewer side effects. The nanoplatform utilizes iron ions to generate highly toxic hydroxyl radicals in the tumor microenvironment, inducing tumor cell death. Additionally, the platform's polydopamine modification enables photothermal responsiveness and the release of glucose oxidase to enhance the Fenton reaction. The integration of Zr ions further accelerates the generation of hydroxyl radicals, leading to a synergistic photothermal/chemodynamic/starvation therapy effect.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Jingwen Tang, Wanwan Yi, Jiahao Yan, Zheng Chen, Hengwei Fan, Dionisio Zaldivar-Silva, Lissette Aguero, Shige Wang
Summary: Early-stage bleeding control and wound healing promotion are crucial for effective wound management. In this study, a carboxymethyl chitosan (CMCS)/poly-?-glutamic acid (?-PGA)/platelet-rich plasma (PRP) hydrogel (CP-PRP hydrogel) was developed, which could be freeze-dried and transformed into a sponge (CP-PRP sponge). The CP-PRP sponge showed enhanced hemostasis effect, released growth factors, and significantly promoted wound healing in a mouse model of full-thickness skin defects, demonstrating its potential as a novel bioactive wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yongliang Ouyang, Yizhou Zhao, Xiaoyi Zheng, Yao Zhang, Jiulong Zhao, Shige Wang, Yubei Gu
Summary: In this study, a multifunctional bio-hemostatic hydrogel (CODM) was prepared using modified alginate, polyvinylpyrrolidone (PVP), and carboxymethyl chitosan. The addition of amino group-modified montmorillonite improved the hemostatic ability of the hydrogel, making it better than commercial hemostatic materials. The CODM hydrogel also demonstrated photothermal conversion ability and antibacterial properties, making it a promising candidate for emergency hemostasis and wound management.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yanbing Song, Jin Xing, Li Ren, Xia Xu, Donghua Han, Hao Xu, Liang Zhao, Yang Yu, Shige Wang, Chaobo Liu
Summary: A multi-functional hydrogel with antibacterial properties, hemostasis, and the ability to promote wound healing is proposed in this study. The hydrogel is composed of surfactin, polyvinylpyrrolidone, and methacrylic anhydride grafted quaternary ammonium chitosan. The formation of the hydrogel is triggered by ultraviolet-initiated polymerization, while surfactin is complexed with the hydrogel through hydrogen bonding interaction. This adhesive hydrogel with shape adaptability can cover the wound surface, simulate the microenvironment of the primary extracellular matrix, and promote collagen deposition and inflammatory factor transformation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
