Article
Clinical Neurology
Zhihua Wang, Zhiwu Wu, Zhiping Xie, Wu Zhou, Meihua Li
Summary: This study found that Met can have a neuroprotective effect on the repair of traumatic spinal cord injury by inhibiting ferroptosis, improving long-term outcomes and reducing locomotor deficits.
WORLD NEUROSURGERY
(2022)
Article
Engineering, Environmental
Wenxin Chen, Sen Lin, Yanfeng Xu, Qiang Guo, Yuanhong Xu, Yusheng Niu
Summary: PA-Zn, a nanozyme with SOD and CAT-like activities, can effectively reduce oxidative stress caused by spinal cord injury, promote neuron survival and functional recovery, and has a good therapeutic effect on SCI.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang
Summary: The study demonstrates that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Cong Li, Wu Xiong, Bowen Wan, Guang Kong, Siming Wang, Yingying Wang, Jin Fan
Summary: Secondary spinal cord injury is caused by an irreversible inflammatory response cascade, and the immune system plays a crucial role in mediating inflammation. Investigating the mechanisms and functions of peripheral immune cells at the site of injury is significant for identifying clinical therapeutic targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhou Feng, Lingxia Min, Hui Chen, Weiwei Deng, Mingliang Tan, Hongliang Liu, Jingming Hou
Summary: The study demonstrated that activated microglia in the motor cortex induced iron overload after SCI, triggering motor neuronal ferroptosis and impeding motor functional recovery. Iron chelator and inhibitors could reduce iron overload-induced neuronal death, potentially offering novel therapeutic strategies for SCI.
Review
Neurosciences
Xin-Yue Bai, Xiao-Long Liu, Zhi-Zhong Deng, Dong-Min Wei, Die Zhang, Hui-Lin Xi, Qing-Yan Wang, Meng-Ze He, Yan-Ling Yang
Summary: Spinal cord injury is a serious traumatic disease, and recent studies have shown that Ferroptosis is closely related to its pathophysiological processes. Iron overload, reactive oxygen species accumulation, lipid peroxidation, and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, indicating the involvement of Ferroptosis in the secondary pathological processes. This article highlights the relationship between Ferroptosis and spinal cord injury, presents substances that improve spinal cord injury by inhibiting Ferroptosis, and discusses the potential challenges in the clinical translation of Ferroptosis inhibitors.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Dachuan Li, Xiao Lu, Guangyu Xu, Siyang Liu, Zhaoyang Gong, Feizhou Lu, Xinlei Xia, Jianyuan Jiang, Hongli Wang, Fei Zou, Xiaosheng Ma
Summary: DHODH attenuates neuronal damage and inhibits ferroptosis in spinal cord injury by reducing lipid peroxide production and mitochondrial damage. In addition, DHODH inhibits ALOX15 expression by inhibiting P53. Therefore, DHODH may serve as a novel therapeutic target for the treatment of spinal cord injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Immunology
Yizhang Mo, Kebing Chen
Summary: High mobility group box 1 (HMGB1) functions both as a nonhistone nucleoprotein and an extracellular inflammatory cytokine. It is mainly located in the nucleus in the resting state and regulates key nuclear activities. After spinal cord injury, HMGB1 is expressed by neurons, microglia, and ependymal cells and released into the extracellular matrix and blood circulation, contributing to the pathophysiological process of spinal cord injury. HMGB1 can regulate microglia activation, exacerbate inflammation, and result in neuronal death. However, it has also been shown to benefit neuron survival, regeneration, and motor function recovery. This article reviews the timing of HMGB1 secretion and translocation, release mechanisms, and its role in spinal cord injury, and identifies challenges to be addressed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Hongfei Ge, Xingsen Xue, Jishu Xian, Linbo Yuan, Long Wang, Yongjie Zou, Jun Zhong, Zhouyang Jiang, Jiantao Shi, Tunan Chen, Hong Su, Hua Feng, Shengli Hu
Summary: Research on white matter injury and ferroptosis following SCI has shown that ferrostatin-1 can reduce white matter damage, promote functional recovery, and has the potential to inhibit the activation of reactive astrocytes and microglia.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Qing-Sheng Li, Yan-Jie Jia
Summary: Ferroptosis is a new form of programmed cell death that is not necrotic and is caused by iron-dependent phospholipid peroxidation. It plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries. Inhibitors against ferroptosis effectively improve iron homeostasis, lipid metabolism, redox stabilization, neuronal remodeling, and functional recovery after trauma. This review elaborates on the latest molecular mechanisms of ferroptosis, emphasizes its role in secondary central nervous trauma, and updates the medicines used to suppress ferroptosis following injuries.
NEURAL REGENERATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Simonetta Papa, Valeria Veneruso, Emanuele Mauri, Giada Cremonesi, Xhuljana Mingaj, Alessandro Mariani, Massimiliano De Paola, Arianna Rossetti, Alessandro Sacchetti, Filippo Rossi, Gianluigi Forloni, Pietro Veglianese
Summary: Astroglial cells have a unique reaction during spinal cord damage, and there is a need for treatment targeting activated astrocytes to ensure some preservative effect during progressive damage. Functionalized nanogel-based nanovectors have shown selectivity towards astrocytes and limited uptake by macrophages, with potential therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Cell Biology
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Summary: Ferroptosis, a novel type of programmed cell death, has been found to be associated with acute central nervous system (CNS) trauma. The processes that induce ferroptosis include iron overload, imbalanced glutathione metabolism, and lipid peroxidation. Understanding the mechanism of ferroptosis is important for studying the pathophysiological process of CNS trauma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Fei Li, Haifan Wang, Hao Chen, Jianing Guo, Xiaoqian Dang, Yi Ru, Haoyu Wang
Summary: Ferroptosis is an iron-dependent form of regulated cell death characterized by membrane lipid peroxidation. It plays an important role in various diseases. Different types of regulated cell death, including ferroptosis, have been found in spinal cord injury, and studying their role in SCI can contribute to a better understanding of the pathophysiological process and treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shan Wen, Yuanlong Li, Xiaolei Shen, Zhe Wang, Kaihua Zhang, Jiawei Zhang, Xifan Mei
Summary: Zinc plays a crucial role in predicting the prognosis and treating spinal cord injury by inhibiting inflammation, regulating autophagy, and reducing oxidative stress. However, excessive zinc can cause damage to neurons.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a traumatic central nervous system injury that can lead to severe nerve damage. Inflammatory response plays a crucial role in secondary injury. Prolonged inflammation can worsen the injured site's microenvironment, resulting in neural function deterioration. Understanding the NF-kappa B pathway and its regulation of inflammation after SCI is crucial for developing new therapies. Inhibiting the NF-kappa B pathway improves the inflammatory microenvironment and enhances neural function recovery, making it a potential therapeutic target for SCI.
MOLECULAR NEUROBIOLOGY
(2023)
